4-Demethoxydaunorubicin
4-Demethoxydaunorubicin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? 4-Demethoxydaunorubicin is a brand name. Its generic name is Idarubicin.
Introduction
4-Demethoxydaunorubicin, also known as IDA, is a chemotherapeutic drug prepared from a naturally occurring anthracycline antibiotic, daunorubicin. IDA is used worldwide to treat patients with acute myelogenous leukemia (AML). 4-Demethoxydaunorubicin is used as the standard for induction therapy among AML patients.Uses for
4-Demethoxydaunorubicin is used to treat acute myelogenous leukemia (AML) in adult and pediatric patients. It is also used in combination with other drugs to treat multiple myeloma.Mechanism of Action
4-Demethoxydaunorubicin interferes with DNA and RNA synthesis, causing the destruction of cancer cells. It works by blocking the enzymes necessary for tumor cell replication and growth.How Long Does It Take to Work?
The effects of 4-Demethoxydaunorubicin can usually be seen within 1-2 weeks of treatment. It may take up to 6 months for your symptoms to completely resolve.Absorption
4-Demethoxydaunorubicin is minimally absorbed from the gastrointestinal tract. The oral bioavailability of IDA is extremely low (less than 1%), meaning that it must be given intravenously to be effective.Route of Elimination
4-Demethoxydaunorubicin is metabolized in the liver and then eliminated in the urine and feces.Dosage
4-Demethoxydaunorubicin should be administered intravenously in doses of 10 to 12 mg/m² of body surface area, over 1 to 4 hours. The dosage may be increased or decreased depending on the patient's individual response and the severity of side effects.Administration
4-Demethoxydaunorubicin must be administered as an intravenous injection or infusion directly into a vein. The infusion solution should be free from particulate matter and other contaminants.Side Effects
Common side effects of 4-Demethoxydaunorubicin include nausea, vomiting, diarrhea, rash, fatigue, headache, hair loss, and pain at the injection site. Other less common side effects may include anemia, depression, confusion, and changes in blood pressure.Toxicity
4-Demethoxydaunorubicin is an antineoplastic and is toxic in humans. Accidental or intentional ingestion of 4-Demethoxydaunorubicin may cause severe nausea, vomiting, abdominal pain, and confusion.Precautions
4-Demethoxydaunorubicin should be used with caution in patients with a history of liver or kidney disease, heart disease, or low white blood cell count.Interactions
4-Demethoxydaunorubicin may interact with other drugs and dietary supplements. It is important to tell your doctor about any medications or supplements you are taking before starting treatment with 4-Demethoxydaunorubicin.Disease Interaction
4-Demethoxydaunorubicin may interact with certain diseases, such as bone marrow depression or clotting disorders. It is important to tell your doctor about any illnesses or diseases you are suffering from before taking 4-Demethoxydaunorubicin.Drug Interactions
4-Demethoxydaunorubicin may interact with other medications. Before starting treatment with 4-Demethoxydaunorubicin, it is important to tell your doctor about any medications or supplements you are taking.Food Interactions
4-Demethoxydaunorubicin may interact with certain foods or beverages. It is important to discuss your diet with your doctor before starting treatment with 4-Demethoxydaunorubicin.Pregnancy Use
4-Demethoxydaunorubicin is not recommended for use during pregnancy. It is important to discuss the risks and benefits of treatment with your doctor.Lactation Use
It is not known if 4-Demethoxydaunorubicin passes into breast milk. The use of 4-Demethoxydaunorubicin during lactation is not recommended.Acute Overdose
An overdose of 4-Demethoxydaunorubicin can cause nausea, vomiting, diarrhea, abdominal pain, anemia, confusion, and coma. Seek emergency medical attention if an overdose is suspected.Contraindications
4-Demethoxydaunorubicin should not be used in patients with a known or suspected hypersensitivity to it or any of its components. It is also contraindicated in patients with severe bone marrow depression or clotting disorders.Use Direction
4-Demethoxydaunorubicin should be administered intravenously according to your doctor's instructions. Carefully follow your doctor's prescribed dosage and administration schedule.Storage Conditions
4-Demethoxydaunorubicin is stored in an inert gas atmosphere at room temperature. It should not be frozen and should be protected from light.Volume of Distribution
The volume of distribution of 4-Demethoxydaunorubicin is 0.5-1 liter/kg.Half-Life
The half-life of 4-Demethoxydaunorubicin is 3-4 hours.Clearance
The clearance of 4-Demethoxydaunorubicin is 0.3-0.7 liters/hr/kg.Here you find in details version of 4-Demethoxydaunorubicin
Some Frequently Asked Questions About 4-Demethoxydaunorubicin
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