Idarubicine
Idarubicine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Idarubicine is a brand name. Its generic name is Idarubicin.
Introduction
Idarubicine, also known as IDA, is a chemotherapeutic drug prepared from a naturally occurring anthracycline antibiotic, daunorubicin. IDA is used worldwide to treat patients with acute myelogenous leukemia (AML). Idarubicine is used as the standard for induction therapy among AML patients.Uses for
Idarubicine is used to treat acute myelogenous leukemia (AML) in adult and pediatric patients. It is also used in combination with other drugs to treat multiple myeloma.Mechanism of Action
Idarubicine interferes with DNA and RNA synthesis, causing the destruction of cancer cells. It works by blocking the enzymes necessary for tumor cell replication and growth.How Long Does It Take to Work?
The effects of Idarubicine can usually be seen within 1-2 weeks of treatment. It may take up to 6 months for your symptoms to completely resolve.Absorption
Idarubicine is minimally absorbed from the gastrointestinal tract. The oral bioavailability of IDA is extremely low (less than 1%), meaning that it must be given intravenously to be effective.Route of Elimination
Idarubicine is metabolized in the liver and then eliminated in the urine and feces.Dosage
Idarubicine should be administered intravenously in doses of 10 to 12 mg/m² of body surface area, over 1 to 4 hours. The dosage may be increased or decreased depending on the patient's individual response and the severity of side effects.Administration
Idarubicine must be administered as an intravenous injection or infusion directly into a vein. The infusion solution should be free from particulate matter and other contaminants.Side Effects
Common side effects of Idarubicine include nausea, vomiting, diarrhea, rash, fatigue, headache, hair loss, and pain at the injection site. Other less common side effects may include anemia, depression, confusion, and changes in blood pressure.Toxicity
Idarubicine is an antineoplastic and is toxic in humans. Accidental or intentional ingestion of Idarubicine may cause severe nausea, vomiting, abdominal pain, and confusion.Precautions
Idarubicine should be used with caution in patients with a history of liver or kidney disease, heart disease, or low white blood cell count.Interactions
Idarubicine may interact with other drugs and dietary supplements. It is important to tell your doctor about any medications or supplements you are taking before starting treatment with Idarubicine.Disease Interaction
Idarubicine may interact with certain diseases, such as bone marrow depression or clotting disorders. It is important to tell your doctor about any illnesses or diseases you are suffering from before taking Idarubicine.Drug Interactions
Idarubicine may interact with other medications. Before starting treatment with Idarubicine, it is important to tell your doctor about any medications or supplements you are taking.Food Interactions
Idarubicine may interact with certain foods or beverages. It is important to discuss your diet with your doctor before starting treatment with Idarubicine.Pregnancy Use
Idarubicine is not recommended for use during pregnancy. It is important to discuss the risks and benefits of treatment with your doctor.Lactation Use
It is not known if Idarubicine passes into breast milk. The use of Idarubicine during lactation is not recommended.Acute Overdose
An overdose of Idarubicine can cause nausea, vomiting, diarrhea, abdominal pain, anemia, confusion, and coma. Seek emergency medical attention if an overdose is suspected.Contraindications
Idarubicine should not be used in patients with a known or suspected hypersensitivity to it or any of its components. It is also contraindicated in patients with severe bone marrow depression or clotting disorders.Use Direction
Idarubicine should be administered intravenously according to your doctor's instructions. Carefully follow your doctor's prescribed dosage and administration schedule.Storage Conditions
Idarubicine is stored in an inert gas atmosphere at room temperature. It should not be frozen and should be protected from light.Volume of Distribution
The volume of distribution of Idarubicine is 0.5-1 liter/kg.Half-Life
The half-life of Idarubicine is 3-4 hours.Clearance
The clearance of Idarubicine is 0.3-0.7 liters/hr/kg.Here you find in details version of Idarubicine
Some Frequently Asked Questions About Idarubicine
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