Zivod
Zivod Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zivod is a brand name. Its generic name is Zidovudine.
Introduction
Zivod, or more commonly known as AZT, is an antiviral medication used to treat HIV/AIDS infections. It is a thymidine analog used to block reverse transcriptase, which is an enzyme in HIV/AIDS that allows the virus to replicate in the infected cells. Zivod is the oldest of its class, and the others used are called NRTIs or nucleoside reverse transcriptase inhibitors.
Uses
Zivod is used to treat HIV/AIDS infections that are already established. It is not a cure, but it is used to prolong the life spans of HIV/AIDS patients. It is taken in combination with other medications to block the virus from replicating in the cells of the body. By taking this medication, patients can allow their immune system to become stronger and attempt to fight the virus.
Mechanism of Action
The primary action of Zivod is to block the reverse transcriptase enzyme. This enzyme allows the HIV/AIDS virus to replicate itself in the cells. By blocking the enzyme, Zivod restricts the virus from replicating in the body which helps to prevent the progression of the disease. Zivod also increases the amount of T-cells, which helps to strengthen the immunity against the virus.
How Long Does It Take to Work?
Zivod typically takes approximately 8-12 weeks from the start of therapy for the patient to see improvements. The full effects of the medication will take about six months to become fully realized. It is important that the patient continue to take Zivod as prescribed even if they do not see any improvements in the first few weeks of therapy.
Absorption, Route of Elimination, and Volume of Distribution
Zivod is readily and rapidly absorbed by the body when taken orally, with peak plasma concentrations typically occurring within 1-2 hours of administration. It is extensively metabolized by the liver after being absorbed, with metabolites being excreted through the kidneys, and the unchanged drug being eliminated mainly in the urine. It has a large volume of distribution, with concentrations in the brain, heart, lungs, liver, and spleen being 3-4 times greater than concentrations in the plasma.
Dosage and Administration
The dosage and frequency of administration will vary depending on the patient's condition and age. For adults infected with HIV, the recommended dose is 300 mg taken orally twice a day. For children and adolescents infected with HIV, the recommended dose is 150mg taken orally twice a day. It is important to take Zivod exactly as prescribed by the doctor.
Side Effects
Common side effects of Zivod include headache, nausea and vomiting, anemia, rash, and lower blood cell count. Other more serious side effects include hepatotoxicity, liver abnormalities, lactic acidosis, and pancreatitis. It is important to contact the prescribing doctor if any side effects occur.
Toxicity and Precaution
When taken in the correct dosages, Zivod is generally well tolerated. However, long term therapy with this medication can cause bone marrow and liver toxicity, so regular blood tests are usually recommended. Patients should always tell their healthcare professional about any other medications they are taking before starting Zivod, as some medications can interact with it.
Interactions
Zivod can interact with other medications, including antiretroviral drugs, anticonvulsants, and barbiturates. It can also interact with certain foods and herbal supplements, so patients should always consult their healthcare provider before taking any new medications, supplements, or foods. Additionally, Zivod can cause a decrease in the effectiveness of certain birth control medications, so an alternative method of birth control should be considered while taking this drug.
Disease and Drug Interactions
Zivod can cause liver enzyme abnormalities, so patients with a history of liver disease should use this medication with caution. Additionally, Zivod can interact with other medications, specifically antiretroviral drugs, so it is important to consult a doctor before taking any new medications, supplements, or herbal products. Additionally, Zivod can lower the effectiveness of certain birth control medications, so an alternative form of birth control should be considered while using this medication.
Food Interactions
Zivod can interact with some foods, such as high-fat meals, as they can reduce the absorption of the drug in the body. Additionally, it is important to note that grapefruit and grapefruit juice can increase the risk of side effects with this medication. Therefore, it is important to consult a doctor before consuming grapefruit or juice while taking Zivod.
Pregnancy Use
Zivod has been classified as a Pregnancy Category B drug, which means that it is not expected to cause harm to the fetus. However, it is important to consult a doctor before taking this medication during pregnancy as it can cause side effects in pregnant women.
Lactation Use
Zivod is excreted in human milk, so it is generally not recommended for use during lactation. The patient should discuss any potential risks with their healthcare provider.
Acute Overdose
An acute overdose of Zivod is unlikely to cause any severe clinical effects or death. Symptoms of an overdose may include nausea, vomiting, and diarrhea. If the patient experiences any of the above symptoms, contact a healthcare provider immediately.
Contraindication
Zivod is not recommended for use by patients that are allergic to its active ingredient or other ingredients in the tablets. Additionally, it should be used with caution in patients that have liver disease or severe anemia, as it can worsen these conditions.
Use Direction
Zivod should be taken exactly as prescribed by the doctor, typically twice a day with meals. It is important to take the medication at the same time each day to get the most benefit. The tablets should not be split or crushed before taking.
Storage Condition
Zivod should be stored at room temperature, away from heat, light, and moisture. Keep the tablets in their original container and out of the reach of children.
Volume of Distribution
The volume of distribution for Zivod is 310 L/kg, which means that is can be found in the body's tissues in concentrations three to four times higher than the concentration in the plasma.
Half Life
The half-life of Zivod is 1-2 hours, which is why it needs to be taken twice a day in order to maintain an effective concentration.
Clearance
The clearance of Zivod in the body is approximately 6 L/h/kg, meaning that it is able to be quickly removed from the body after being used.
Here you find in details version of Zivod
Some Frequently Asked Questions About Zivod
What is Zivod?
Zivod (also known as AZT) is an antiviral drug used to treat HIV infection and prevent its transmission during pregnancy.
What is the purpose of Zivod?
The purpose of Zivod is to control the replication of the HIV virus and slow the progression of the disease, thus improving the life expectancy of those infected.
How long does Zivod take to work?
Zivod typically begins to work within several weeks and may take several months to reach its maximal effectiveness.
Does Zivod have any common side effects?
Common side effects of Zivod include nausea, vomiting, anemia, headache, and muscle pain. Other more serious side effects are rare but may include rashes, pancreatitis, and liver problems.
What is the recommended dosage for Zivod?
The recommended initial dose of Zivod is 600 mg, taken orally twice daily. The dosage may be adjusted based on your doctor's instructions.
Is Zivod safe for pregnant women?
Yes, Zivod has been approved by the FDA for use during pregnancy to prevent the transmission of HIV from mother to child.
When should I take Zivod?
Your doctor will likely advise you to take Zivod with food, preferably at the same times each day.
What should I do if I miss a dose of Zivod?
If you miss a dose of Zivod, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume taking the medication as prescribed.
Can I take other medications while on Zivod?
Some medications may interact negatively with Zivod, so it is important to discuss other medications you are taking with your doctor.
How long do I have to take Zivod?
You should follow your doctor's instructions regarding how long you should take Zivod. Generally, however, treatment with Zivod can last for many years.
What should I tell my doctor before taking Zivod?
You should tell your doctor about all other medications you are taking, as well as any allergies you have and conditions you suffer from. You should also tell your doctor if you are pregnant or plan to become pregnant.
What should I avoid while taking Zivod?
You should avoid alcohol, smoking, and illegal drug use while taking Zivod. You should also avoid taking any other medications that are not approved by your doctor.
Will taking Zivod help prevent the spread of HIV?
Yes, Zivod can reduce the risk of spreading HIV from mother to child during pregnancy, and also reduce the risk of spreading HIV through sexual contact.
Can I still transmit HIV if I am taking Zivod?
Yes, you can still transmit HIV even if you are taking Zivod. It is important to practice safe sex and always use a condom to reduce the risk of transmitting HIV.
How long should I wait before taking Zivod after being exposed to HIV?
You should speak with your doctor as soon as possible after possible exposure to HIV in order to assess whether taking Zivod is necessary.
What is the risk of developing drug resistance with Zivod?
The risk of developing drug resistance when taking Zivod is low, however, taking other medications at the same time can increase the risk of drug resistance.
Are there any alternatives to Zivod?
Yes, there are a number of other anti-HIV medications available that may be used as alternatives to Zivod, such as lamivudine, tenofovir, and abacavir.
Is Zivod covered by insurance?
Your insurance provider may cover some or all of the cost of Zivod, depending on your individual coverage.
What should I do if I experience symptoms of an allergic reaction while taking Zivod?
If you experience symptoms of an allergic reaction while taking Zivod, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek medical attention immediately.
What should I do if I experience any side effects while taking Zivod?
If you experience any side effects while taking Zivod, such as nausea, anemia, headache, or muscle pain, contact your doctor. Depending on the severity of your symptoms, your doctor may advise you to reduce your dosage or switch to another medication.
Can Zivod be taken with other drugs?
Yes, but it is important to speak with your doctor before combining Zivod with any other drugs as some drug interactions may be harmful.
How long does it take for Zivod to leave the body?
The half-life of Zivod is 3 to 5 hours, meaning it should generally take less than 24 hours for the drug to be completely eliminated from the body.
Does Zivod interact with other drugs, such as acetaminophen?
Yes, acetaminophen may interact with Zivod, and should be avoided unless advised otherwise by your doctor.
Does taking Zivod cause dehydration?
Yes, taking Zivod can cause dehydration due to the drug’s diuretic effect. Therefore, it is important to drink plenty of fluids while taking Zivod.
Can I take a break from taking Zivod?
No, you should not suddenly stop taking Zivod without consulting your doctor first. If you wish to take a break, it is important to speak to your doctor first.
Can I take Zivod with food?
Yes, taking Zivod with food may reduce any potential side effects such as nausea and headache.
Is Zivod the best treatment for HIV?
No, Zivod is only one of many treatments available for HIV. Your doctor can provide more information on the best treatment options for your individual needs.
How will I know if the Zivod is working?
Your doctor will be able to monitor your progress with regular blood tests, which will indicate whether the medication is controlling the virus.
What should I do if I experience drowsiness while taking Zivod?
If you experience drowsiness while taking Zivod, you should stop taking the medication and contact your doctor immediately.
What other precautionary measures should I take while taking Zivod?
You should avoid caffeine, alcohol, and smoking while taking Zivod. Additionally, you should avoid exposure to sunlight and wear sunscreen and protective clothing to protect your skin while taking Zivod.
Can I take Zivod while breastfeeding?
No, taking Zivod while breastfeeding is not typically recommended as the medication may be passed to the baby through breast milk.
What should I do if I experience kidney pain while taking Zivod?
If you experience kidney pain while taking Zivod, contact your doctor immediately as this may be a sign of serious liver damage.
Can I take Zivod with other vitamins and supplements?
Some vitamins and supplements may interact negatively with Zivod, so you should ask your doctor before taking any additional supplements or vitamins while taking Zivod.
Does Zivod cause birth defects?
No, taking Zivod during pregnancy is not associated with an increased risk of birth defects.
Should I be tested for HIV before taking Zivod?
Yes, it is important to be tested for HIV before taking Zivod to ensure that you are able to receive the most effective treatment.
Can I take Zivod with other antiviral medications?
Yes, you may be able to take Zivod in combination with other antiviral medications, however, you should always speak with your doctor before doing so.
Can I take Zivod with antacids?
Yes, Zivod can be taken with antacids, however, you should speak with your doctor or pharmacist about when to take the medications in order to maximize their effectiveness.
Can Zivod be taken with over-the-counter medications?
Some over-the-counter medications may interact negatively with Zivod, so it is important to speak with your doctor before taking any over-the-counter medications while taking Zivod.
Which side effects of Zivod should I report to my doctor?
You should report any serious side effects such as rash, pancreatitis, or liver problems to your doctor as soon as possible. Additionally, you should discuss any other side effects that become bothersome or persistent.