Zinase

Zinase Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zinase is a brand name. Its generic name is Aceclofenac.

Introduction

Zinase is a non-steroidal anti-inflammatory drug (NSAID) used to manage pain, swelling, and inflammation due to various medical conditions. It is the racemic mixture of the two forms of a compound. It was developed in 1968 and approved for medical use in 1993.

Uses

Zinase is used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used in the treatment of musculoskeletal disorders, such as neck and back pain, sports injuries, sprains and strains, tendinitis, and bursitis.

Mechanism of Action

Zinase works by blocking the production of prostaglandins, hormones that cause inflammation and pain. By blocking this action, it reduces the pain and inflammation caused by these conditions.

How Long Does It Take to Work?

Zinase typically takes up to 2 weeks for its effect to be fully manifested. However, most patients experience relief within a few days.

Absorption

Zinase is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine and feces.

Route of Elimination

Zinase is secreted in the urine and feces. It is also partially metabolized by the liver.

Dosage

Zinase is available in 50 mg, 100 mg, and 200 mg doses. The recommended dose is one to two tablets taken orally every 8-12 hours as needed for pain relief. The maximum daily dose is 800 mg per day. The dose may be increased or decreased based on individual response and tolerance.

Administration

Zinase tablets should be taken orally, with or without food, as directed by your doctor. The tablets should be swallowed whole and should not be chewed or crushed.

Side Effects

Common side effects of Zinase include gastrointestinal discomfort, nausea, headache, dizziness, and rash. Serious side effects include difficulty breathing, chest pain, and liver or kidney problems. Contact your doctor if you experience severe or persistent side effects.

Toxicity

Zinase is generally well-tolerated, however, overdoses can result in serious toxicity. Symptoms of overdose include blurred vision, difficulty breathing, confusion, seizures, and coma. Seek immediate medical attention if you or someone you know has overdosed on this medication.

Precaution

Zinase should be taken with caution if you have a history of kidney, liver, or gastrointestinal disorder, asthma, dehydration, or blood clotting disorder. You should also avoid taking alcohol or other medications that can irritate the stomach while taking aceclofenac.

Interactions

Zinase may interact with certain other medications. Be sure to inform your doctor of any medications, supplements, or vitamins you are currently taking. This medication may also interact with other medical conditions or lifestyle choices.

Drug Interactions

Zinase can interact with certain other medications, including anti-inflammatory drugs, antidepressants, blood thinners, antibiotics, antifungal medications, and vitamin supplements. Be sure to tell your doctor and pharmacist about all medications you are currently taking, including any over-the-counter medications.

Food Interactions

Zinase may interact with certain foods. It is important to talk to your doctor about any dietary restrictions or food interactions that may occur when taking this medication.

Pregnancy Use

Zinase should not be used during pregnancy as it may cause harm to the fetus. Women who are pregnant or planning to become pregnant should not take this medication.

Lactation Use

Zinase should not be used during lactation as it may be secreted into breast milk. Women who are breastfeeding should not take this medication.

Acute Overdose

Overdose of aceclofenac can be potentially life-threatening. Symptoms of overdose include, blurred vision, difficulty breathing, confusion, seizures, and coma. Seek immediate medical attention if you or someone you know has overdosed on this medication.

Contraindication

Zinase should not be used in people with a history of stomach or intestinal ulcer, liver and kidney disease, and patients with a history of hypersensitivity to other drugs including Zinase.

Use Direction

Zinase should be taken exactly as prescribed by your doctor. Do not take more or less of the medication than directed. Do not take the medication more or less frequently than directed.

Storage Condition

Zinase should be stored at room temperature, away from light, moisture, and heat. Keep away from children and pets.

Volume of Distribution

Zinase has a large volume of distribution and is widely distributed throughout the body.

Half Life

The elimination half-life of aceclofenac is approximately 6 hours.

Clearance

Zinase is cleared from the body primarily by the kidneys. The oral clearance of the drug is approximately 40 mL/min.

Here you find in details version of Zinase

Some Frequently Asked Questions About Zinase

What is Zinase?

Zinase is a non-steroidal anti-inflammatory drug (NSAID) used for treating pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

What is the mechanism of action of Zinase?

Zinase is thought to work by inhibiting the activity of the enzyme cyclooxygenase (COX). Inhibition of COX leads to decreased synthesis of pro-inflammatory and painmediating prostaglandins, resulting in a reduction in inflammation and pain.

What is the dosage of Zinase?

The recommended adult dose of Zinase is 100 to 200 mg twice daily or as directed by the physician.

What are the side effects of Zinase?

The common side effects of Zinase include stomach upset, heartburn, nausea, vomiting, diarrhea, drowsiness, headache, constipation, joint pain, rash and itching.

What should be avoided while taking Zinase?

Alcohol should be avoided while taking Zinase as it can increase the risk of stomach ulcers and bleeding. ACE inhibitors, anticoagulants, diuretics, NSAIDs, and corticosteroids should also be avoided while taking Zinase.

Can Zinase be used for migraine?

Zinase is not usually recommended for the treatment of migraine headaches, although some patients may find it to be effective. Patients should discuss this with their doctor to determine if Zinase is an appropriate treatment.

Can I take Zinase with paracetamol?

Yes, it is safe to take Zinase with paracetamol. However, it is important to follow the dosages as prescribed by your doctor, and not to exceed the recommended dosages.

Can I take Zinase during pregnancy?

Zinase is not recommended during the first and third trimester of pregnancy. There is limited data on its use and safety during the second trimester of pregnancy, and it should be used only if the potential benefits outweigh the risks.

Is Zinase a muscle relaxant?

No, Zinase is not a muscle relaxant. It is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

Can Zinase be used for headaches?

Zinase is not usually recommended for the treatment of headache. Patients should discuss this with their doctor to determine if Zinase is an appropriate treatment.

What are the serious side effects of Zinase?

Serious side effects of Zinase include signs of allergic reactions (hives, difficulty breathing, swelling of the face, lips, tongue, or throat), chest pain, increased blood pressure, shortness of breath, and bloody or black, tarry stools.

What is the difference between Zinase and Ibuprofen?

Zinase and ibuprofen are both non-steroidal anti-inflammatory drugs (NSAIDs) used for reducing pain and inflammation. The main difference between them is that Zinase is thought to have fewer gastrointestinal side effects than ibuprofen.

Can I take Zinase if I have high blood pressure?

Yes, you can take Zinase if you have high blood pressure. However, it is important to follow the dosages as prescribed by your doctor, and not to exceed the recommended dosages.

Is Zinase safe?

Zinase is generally safe and well-tolerated when taken at prescribed doses. However, it can cause side effects such as stomach upset, heartburn, nausea, vomiting, diarrhea, drowsiness, headache, constipation, joint pain, rash and itching.

Can Zinase be used to treat fever?

No, Zinase is not usually recommended for the treatment of fever. It is used to reduce pain and inflammation associated with conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

How long does Zinase take to work?

Zinase usually starts to work within a few hours of taking it. Maximum effects are usually seen within 1-2 weeks.

Can I take Zinase with warfarin?

No, it is not recommended to take Zinase with warfarin as it could increase the risk of bleeding. If you are taking warfarin then you should discuss this with your doctor before taking Zinase.

What is the maximum daily dose of Zinase?

The maximum daily dose of Zinase is 400 mg per day. Higher doses are not recommended and patients should not exceed the recommended dose.

Is Zinase available over the counter?

No, Zinase is a prescription medication available only through a doctor's prescription.

Is Zinase a strong painkiller?

Zinase is a medium strength painkiller used for treating pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

Can Zinase be used to treat gout?

Yes, Zinase can be used to treat gout. However, it is important to follow the dosage as prescribed by the doctor and not to exceed the recommended dosage.

Can Zinase be taken with food?

Yes, it is generally recommended to take Zinase with food or after meals to reduce the risk of stomach upset. It is important to follow your doctor's instructions when taking this medication.

Can I take Zinase before surgery?

No, it is not recommended to take Zinase before surgery as it may increase the risk of bleeding. You should discuss this with your doctor before taking this medication.

What should be done in case of an overdose?

If an overdose of Zinase is suspected then medical attention should be sought immediately. Symptoms of an overdose may include nausea, vomiting, dizziness, abdominal pain, and drowsiness.

What precautions should I take while using Zinase?

It is important to follow all the instructions and precautions provided by the doctor while taking Zinase. It is also important to keep your doctor updated about any medical conditions you have and be aware of any medications, supplements, or herbal remedies you are taking that could interact with Zinase.

What drug interactions can occur when taking Zinase?

Zinase may interact with certain drugs, such as ACE inhibitors, anticoagulants, diuretics, NSAIDs, and corticosteroids. It is important to discuss with your doctor any medications, supplements, or herbal remedies you are taking, to prevent any potential drug interactions.

Is Zinase safe for long-term use?

Zinase is generally safe when taken for a short period of time. Long-term use of Zinase can increase the risk of side effects, such as gastrointestinal bleeding, increased risk of heart attack, stroke, and kidney damage. If you are taking Zinase for a long-term period, it is important to discuss this with your doctor.

Can Zinase cause anemia?

Yes, long-term use of Zinase can cause anemia due to decreased production of red blood cells. If you are taking Zinase for long-term use, it is important to discuss with your doctor about the potential risks of anemia.

Can Zinase cause liver damage?

Yes, Zinase can cause liver damage in rare cases. If you experience any signs of liver damage such as yellowing of the eyes or skin, dark urine, or abdominal pain, you should seek medical attention immediately.

Can Zinase cause kidney damage?

Yes, long-term use of Zinase can cause kidney damage in rare cases. If you experience any signs of kidney damage such as decreased urination, nausea, vomiting, or fluid retention, you should seek medical attention immediately.

Can Zinase cause weight gain?

No, Zinase does not usually cause weight gain. However, it is possible for certain side effects, such as abdominal pain, nausea, and vomiting, to lead to decreased appetite and weight loss.

Can I take Zinase with aspirin?

No, it is not recommended to take Zinase with aspirin as it may increase the risk of stomach ulcers and bleeding. If you are taking aspirin then you should discuss this with your doctor before taking Zinase.

Can I take Zinase for menstrual cramps?

Yes, Zinase can be used to treat mild to moderate menstrual cramps. However, it is important to follow the dosage as prescribed by the doctor and not to exceed the recommended dosage.

Does Zinase cause drowsiness?

Yes, Zinase may cause drowsiness. If you experience drowsiness after taking this medication then it is important to avoid activities that require alertness such as driving or operating machinery.

Does Zinase interact with warfarin?

Yes, Zinase can interact with warfarin and increase the risk of bleeding. If you are taking warfarin then you should discuss this with your doctor before taking Zinase.

What is the onset of action of Zinase?

The onset of action of Zinase is usually within a few hours of taking it. Maximum effects are usually seen within 1-2 weeks.

How long does Zinase take to work?

The effects of Zinase may take a few hours to be felt. Maximum effects are usually seen within 1-2 weeks.

Is Zinase safe for children?

Zinase is not recommended for use in children under 12 years of age. If a child needs to take this medication then it should be taken only under the supervision of a doctor.

Can Zinase be taken with food?

Yes, it is generally recommended to take Zinase with food or after meals to reduce the risk of stomach upset. It is important to follow your doctor's instructions when taking this medication.

What is the half-life of Zinase?

The half-life of Zinase is approximately 8 to 12 hours.

Is Zinase addictive?

No, Zinase is not addictive.

Can I take Zinase if I have asthma?

Yes, you can take Zinase if you have asthma. However, it is important to discuss this with your doctor to ensure that Zinase is