Zehist
Zehist Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zehist is a brand name. Its generic name is Mizolastine.
Zehist
Zehist is an antihistamine drug used for the prevention and treatment of allergic reactions, particularly seasonal allergic rhinitis (hay fever) and chronic urticaria. It was approved in the United States in 2004 to treat allergic rhinitis.
Uses and Mechanism of Action
Zehist is an antihistamine drug used to treat allergies and for the prevention and treatment of symptoms associated with seasonal allergic rhinitis (hay fever) and chronic urticaria. Histamine is a chemical released by the body during an allergic reaction, and mizolastine works by blocking the action of this chemical, thereby preventing or reducing the symptoms of an allergic reaction. Zehist is a long-acting antihistamine, meaning it can provide relief from symptoms of allergic reactions for up to 24 hours.
How Long Does it Take to Work?
Zehist begins to work within 1 to 2 hours after it has been taken. The effects may last up to 24 hours.
Absorption, Route of Elimination, and Dosage
Zehist is absorbed rapidly after oral administration, with peak levels occurring within 1 to 2 hours. Zehist is eliminated predominantly by the kidneys, with some excretion of the drug in feces. The recommended dose for adults is 10 mg once daily, taken 30 minutes before food or two hours after a meal. Zehist is available as tablets.
Administration, Side Effects, Toxicity, and Precautions
Zehist is administered orally, usually in the form of tablets, 30 minutes before meals or two hours after meals. The most common side effects include tiredness, dry mouth, nausea, and stomach discomfort. Less common side effects include dizziness, headache, and constipation. Zehist has a low toxicity but should be used with caution in patients with glaucoma, diabetes, thyroid disease, or an enlarged prostate. Patients who are pregnant or nursing should consult with their healthcare provider before taking mizolastine.
Interactions, Disease Interactions, Drug Interactions, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose, and Contraindications
Zehist may interact with other drugs, particularly other antihistamines and sedatives, and may also interact with certain foods and beverages. Zehist is contraindicated in patients who are hypersensitive to it or who have severe liver disease. Zehist is not recommended for use in pregnant or nursing mothers and should be used with caution in patients with glaucoma, diabetes, thyroid disease, or an enlarged prostate. Zehist should also be used with caution in patients with depression or kidney disease. There is no known acute overdose of mizolastine.
Use Direction, Storage Conditions, Volume of Distribution, Half Life, and Clearance
Zehist should be taken as directed and should not be taken more than once a day. It should be stored at room temperature away from direct sunlight and moisture. Zehist has a volume of distribution of 6 L/kg and a half-life of 10 hours. The drug is cleared from the body mainly through the kidneys.
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