xtandi
xtandi Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? xtandi is a brand name. Its generic name is Enzalutamide.
xtandi Introduction
xtandi is a prescription medication used to treat prostate cancer that no longer responds to medical or surgical treatments. It belongs to a class of drugs called anti-androgens, which block the action of testosterone. It works by blocking certain proteins in the body that play a role in the growth of prostate cancer cells.
Uses for xtandi
xtandi is used to treat metastatic androgen receptor-positive castration-resistant prostate cancer. Castrate-resistant prostate cancer is cancer that is typically resistant to hormone therapy.
Mechanism of Action
xtandi works by blocking androgen receptors. This prevents testosterone and other androgen hormones from binding to androgen receptors and migrating into cells that have androgen receptors. By blocking androgen receptors, xtandi inhibits the growth and spread of prostate cancer cells.
How Long Does It Take to Work?
The effects of xtandi can be seen in as little as 8 weeks following the start of treatment. In clinical studies, prostate cancer remained stable or decreased for an average of one year when xtandi was used. Keep taking xtandi even if you feel well.
Absorption
xtandi is absorbed rapidly and almost completely following oral administration with peak blood levels reached within 1-2 hours. It has a bioavailability of around 80%. The absorption of the drug is decreased by food, and it should be taken on an empty stomach.
Route of Elimination
xtandi is metabolized in the liver by enzymes and is eliminated primarily in urine. The mean elimination half-life of xtandi is approximately 5 hours.
Dosage
The recommended starting dosage of xtandi is 160 mg taken orally once daily. If you have any side effects that become bothersome, talk to your doctor about adjusting your dosage. Your doctor may also adjust your dosage if you have any medical conditions that may cause adverse reactions.
Administration
xtandi should be taken once a day before or after a meal. It can be taken with or without food. Take it at the same time each day to maintain an even level of the medication in your blood.
Side Effects
Common side effects of xtandi include weakness, headache, hot flashes, fatigue, joint pain, nausea, diarrhea, decreased appetite, insomnia, and dizziness.
Toxicity
xtandi is a relatively safe medication, but high doses or long-term use can lead to severe adverse effects, including liver damage. If you experience any signs of liver damage, such as yellowing of the skin or eyes, dark urine, nausea, vomiting, or abdominal pain, contact your doctor immediately.
Precautions
xtandi should be used with caution in patients with kidney or liver impairment, or in those who are taking medications that affect the liver. Tell your doctor if you have any allergies, are undergoing radiation or chemotherapy treatment, or have any other medical conditions.
Interaction
xtandi can interact with certain medications, including antifungals, HIV protease inhibitors, anticonvulsants, and medications that contain rifampin. Inform your doctor about all medications, vitamins, and supplements you are taking prior to using xtandi.
Disease Interaction
xtandi can have serious interactions with certain diseases, including heart disease, liver disease, kidney disease, and diabetes. If you are currently being treated for any of these conditions, tell your doctor before starting xtandi.
Drug Interaction
xtandi may interact with certain drugs, including warfarin, digitoxin, cimetidine, and antacids. Be sure to let your doctor know if you are taking any of these medications before starting xtandi.
Food Interaction
xtandi should be taken with a full glass of water. It should not be taken with food as this may decrease the absorption of the drug. It should also be taken consistently, either with or without food.
Pregnancy Use
xtandi should not be used by pregnant women. If you are pregnant or planning to become pregnant, tell your doctor before taking this medication.
Lactation Use
xtandi should not be taken by breastfeeding mothers. If you are breastfeeding or planning to breastfeed, tell your doctor before taking this medication.
Acute Overdose
If you think you have taken too much of this medicine contact a poison control center or emergency room immediately. Symptoms of acute overdose may include vomiting, confusion, and drowsiness.
Contraindication
xtandi should not be used if you are allergic to it or any of its ingredients, or if you have a history of liver or kidney disease. Talk to your doctor before taking xtandi.
Use Direction
xtandi should be taken as directed by your doctor. Take the medication exactly as prescribed and do not change or alter your dosage without consulting your doctor. Do not stop taking the medication without consulting your doctor.
Storage Condition
xtandi should be stored at room temperature and protected from light. Keep it away from children and pets. Do not keep medicine that is expired or no longer needed.
Volume of Distribution
The volume of distribution of xtandi is 18 L. This indicates that the drug is widely distributed throughout the body and that it has a low risk of accumulation in the tissues.
Half Life
The half-life of xtandi is approximately 5 hours. This means the amount of xtandi in your system will be half of its original amount after 5 hours. The elimination of xtandi can vary based on liver function, age, and other factors.
Clearance
The clearance of xtandi is 25.6 L/hr. This indicates that xtandi is rapidly eliminated from the body with a short half-life.
Here you find in details version of xtandi