Xpotil

Xpotil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Xpotil is a brand name. Its generic name is Cefpodoxime.

Introduction

Xpotil (also referred to as cefpodoxime proxetil) is an antibiotic used to treat sinus infections, bronchitis, pneumonia, ENT infections, skin infections, and certain urinary tract infections. The drug belongs to a class of antibiotics called cephalosporins and is produced in oral, and intravenous formats.

Uses

Xpotil is used to treat a variety of bacterial infections such as sinusitis, bronchitis, pneumonia, otitis media, cellulitis, urinary tract infections, skin and skin structure infections, and pharyngitis/tonsillitis.

Mechanism of Action

Xpotil works by inhibiting bacterial cell wall synthesis. This leads to an influx of water and causes the cell wall to rupture, thus killing the bacteria. In addition, the drug has some activity against certain types of fungi, viruses and protozoa.

How Long Does It Take to Work

Xpotil usually begins to take effect within 1-2 days of administration. However, it may take up to 5-7 days to experience full relief of symptoms.

Absorption, Route of Elimination, Dosage and Administration

Xpotil is rapidly and almost completely absorbed from the gastrointestinal tract. The drug is eliminated primarily through the kidneys and the excretion rate is slow. The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours. Oral suspension formulations are available in 50 and 100 mg/5 mL strengths.

Side Effects

Common side effects of cefpodoxime include diarrhea, nausea, vomiting, abdominal pain, dizziness, headache, fatigue, rash, and skin sensitivity. Severe side effects include anaphylaxis, kidney damage, and fainting. Xpotil can also cause abnormal liver function test results and thrombocytopenia.

Toxicity

Xpotil is generally well-tolerated. Overdose symptoms include nausea, vomiting, diarrhea, dizziness, rapid heart rate, and rare seizures.

Precautions

Xpotil should be avoided in patients with history of allergy to cephalosporins. The drug should not be used in patients with impaired kidney or liver function. It should also be used with caution in pregnant and breastfeeding women.

Interaction

Xpotil may interact with other medications such as antacids, warfarin, digoxin, probenecid, and certain drugs for HIV/AIDS, etc. Drugs that interact with cefpodoxime include: paroxetine; phenytoin; ritonavir; certain fluoroquinolone antibiotics such as ciprofloxacin, norfloxacin, and ofloxacin; and certain anti-seizure drugs such as phenytoin, valproic acid, and carbamazepine.

Disease Interaction

Xpotil may interact with certain medical conditions such as kidney disease, history of allergic reactions to other cephalosporin antibiotics, and intestinal inflammation due to infection or the use of antibiotics. Xpotil should be used with caution in patients with kidney disease. It should not be used in patients if there is an existing intestine infection or if the patient has recently been taking antibiotics.

Drug Interaction

Drug interactions may occur when cefpodoxime is taken with other medications such as antacids, warfarin, probenecid, and certain HIV drugs. Xpotil should not be used together with drugs like paroxetine, phenytoin, ritonavir, certain fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin), certain anti-seizure drugs (phenytoin, valproic acid, carbamazepine), etc. Patients should inform their physicians of any medications they are currently taking before taking cefpodoxime.

Food Interactions

Xpotil should be taken with a full glass of water. Food can decrease the absorption of cefpodoxime, so the drug should be taken at least 2 hours before or after a meal. Avoid consumption of dairy products, antacids, iron supplements, and vitamins within 2 hours of taking cefpodoxime.

Pregnancy Use

Xpotil is likely safe to use during pregnancy. However, it is best to consult a doctor before taking cefpodoxime during pregnancy.

Lactation Use

Xpotil is not known to be harmful when breastfeeding. However, it is best to consult a doctor before taking cefpodoxime while breastfeeding.

Acute Overdose

Acute overdose of cefpodoxime can result in nausea, dizziness, rapid heart rate, and seizures. Seek medical help if overdose is suspected.

Contraindication

Xpotil is contraindicated in patients with known allergy to cephalosporins.

Dosage Information

The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours.

Direction of Use

Xpotil should be taken orally with a full glass of water. It should be taken with or without food. It should not be taken with dairy products, antacids, iron supplements, or vitamins.

Storage Condition

Xpotil should be stored in a tight container, away from light and moisture, at room temperature (15-30°C).

Volume of Distribution

Xpotil has a volume of distribution of 0.3 - 0.5 L/kg.

Half-Life

The average half-life of cefpodoxime is about 2 - 4 hours.

Clearance

The average clearance of cefpodoxime is 50 - 70 mL/min.

Here you find in details version of Xpotil

Some Frequently Asked Questions About Xpotil

What is Xpotil?

Xpotil is an antibiotic used to treat certain types of bacterial infections. It belongs to a class of antibiotics called cephalosporins that work by stopping the growth of bacteria.

What infections does Xpotil treat?

Xpotil is used to treat infections caused by certain bacteria, such as lower respiratory tract infections, otitis media (middle ear infections), skin infections, and urinary tract infections.

How does Xpotil work?

Xpotil works by attacking the bacteria that cause the infection. It works by interfering with the bacteria’s ability to make cell walls, which results in the death of the bacteria.

Who should take Xpotil?

Xpotil should be taken by those who have been prescribed it by a doctor to treat a bacterial infection. It should not be taken by anyone who has an allergy to cephalosporin antibiotics.

How do I take Xpotil?

Xpotil should be taken as directed by your doctor. The dosage and length of treatment will depend on the infection being treated. The tablets should be taken with a full glass of water. If you forget to take a dose, take it as soon as you remember.

What are the possible side effects of taking Xpotil?

Some common side effects of taking Xpotil may include nausea, vomiting, diarrhea, or skin rash. Serious side effects include easy bleeding or bruising, yellowing skin or eyes, chest pain, or difficulty breathing. Tell your doctor if you experience any of these side effects.

What if I am allergic to Xpotil?

If you are allergic to Xpotil or other cephalosporin antibiotics, do not take this drug. Tell your doctor about any allergies that you have before beginning treatment.

Can I take Xpotil with other medications?

Before taking Xpotil, tell your doctor if you are taking any other medications, especially probenecid, sulfamethoxazole, or valproic acid. Some medications may interact with Xpotil, so it is important to discuss them with your doctor before beginning treatment.

Can Xpotil be used to treat a viral infection?

No, Xpotil is not effective for treating viral infections since it only attacks bacterial infections.

What is the recommended dosage for Xpotil?

The recommended dosage of Xpotil depends on the infection being treated and on the patient's age and weight. It is important to follow your doctor's instructions when taking Xpotil.

Can Xpotil be used during pregnancy?

Xpotil is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication during pregnancy.

Can I miss a dose of Xpotil?

If you miss a dose of Xpotil, take it as soon as possible. However, if it is close to the time for your next dose, skip the missed dose and continue with your normal schedule.

Is Xpotil safe for children?

Yes, Xpotil is safe to use in children. However, it is important to follow your doctor's instructions for dosage and duration of treatment.

Does Xpotil have any interactions with food?

No, Xpotil does not have any known food interactions.

Can I drink alcohol while taking Xpotil?

It is not recommended to drink alcohol while taking Xpotil, as it may increase the chance of side effects.

Does Xpotil cause headaches?

Xpotil can cause headaches as a side effect in some people. If you experience headaches while taking Xpotil, contact your doctor.

How long should I take Xpotil?

Your doctor will determine how long you should take Xpotil. It is important to follow your doctor’s instructions for the duration of treatment.

Can Xpotil affect the liver?

Xpotil can potentially cause liver damage in rare cases. If you notice any symptoms of liver damage, such as yellowing of the skin or eyes, contact your doctor.

What should I do if I develop an allergic reaction to Xpotil?

If you develop an allergic reaction while taking Xpotil, stop taking the medication and contact your doctor immediately.

Is Xpotil available as a generic drug?

Yes, Xpotil is available as a generic drug.

Does Xpotil cause drowsiness?

Xpotil can cause drowsiness as a side effect in some people. If you experience drowsiness while taking Xpotil, contact your doctor.

Can I take Xpotil with other antibiotics?

No, Xpotil should not be taken with other antibiotics since it can lead to increased side effects and altered effectiveness.

Can Xpotil treat sore throats?

No, Xpotil is not effective for treating sore throat caused by viral infections.

Can Xpotil be used to treat bacterial meningitis?

Yes, Xpotil can be used to treat bacterial meningitis.

Can Xpotil be used to treat strep throat?

Yes, Xpotil can be used to treat strep throat.

Is Xpotil available in other forms such as an oral suspension?

Yes, Xpotil is also available as an oral suspension.

Can I take Xpotil for a long period of time?

It is not recommended to take Xpotil for a long period of time, as it can lead to overgrowth of certain bacteria and lead to antibiotic resistance.

Can I take Xpotil with ibuprofen?

Yes, Xpotil can be taken with ibuprofen.

Is it safe to take Xpotil while breastfeeding?

It is not recommended to take Xpotil while breastfeeding because it can pass into breast milk and affect the infant. Contact your doctor before taking Xpotil while breastfeeding.

Can Xpotil be used to treat ear infections?

Yes, Xpotil can be used to treat ear infections.

Can Xpotil treat urinary tract infections?

Yes, Xpotil can be used to treat urinary tract infections.

Is Xpotil safe for people with kidney or liver disease?

People with kidney or liver disease should use Xpotil with caution, as it is broken down by the kidneys and liver. Talk to your doctor before taking Xpotil if you have kidney or liver disease.

Can Xpotil make you tired?

Yes, Xpotil can cause fatigue as a side effect in some people. Talk to your doctor if you experience fatigue while taking Xpotil.

How often do I need to take Xpotil?

You should take Xpotil as directed by your doctor. The frequency of doses will depend on the infection as well as the patient’s age and weight.

What laboratory tests should be done while taking Xpotil?

Your doctor may recommend certain laboratory tests such as a complete blood count, liver function tests, or kidney function tests while taking Xpotil.

Can Xpotil be used in animals such as cats or dogs?

Yes, Xpotil can be used in cats and dogs, but only under the direction of a veterinarian.

What should I do if I miss a dose of Xpotil?

If you miss a dose of Xpotil, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue on your regular schedule.

What can happen if I take an overdose of Xpotil?

If you take an overdose of Xpotil, contact your doctor or local poison control center immediately. Symptoms of an overdose may include nausea, dizziness, or difficulty breathing.

Should I avoid activities that require mental alertness while taking Xpotil?

Yes, it is best to avoid activities that require mental alertness while taking Xpotil because it can cause drowsiness and dizziness as side effects.

Can Xpotil cause nausea and vomiting?

Yes, Xpotil can cause nausea and vomiting as side effects. Talk to your doctor if you experience nausea and vomiting while taking Xpotil.