Xarelto
Xarelto Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Xarelto is a brand name. Its generic name is Rivaroxaban.
Introduction
Xarelto is an anticoagulant (blood thinner) that helps keep blood clots from forming in the body. It is used to reduce the risk of stroke and blood clotting (thrombosis) in people who have atrial fibrillation (a type of irregular heart rhythm) that is not caused by a heart valve problem. Xarelto is also used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE), and to prevent DVT and PE in people undergoing hip replacement surgery.Uses
Xarelto is used to reduce the risk of stroke and blood clotting (thrombosis) in people who have atrial fibrillation (a type of irregular heart rhythm) that is not caused by a heart valve problem. It is also used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE), and to prevent DVT and PE in people undergoing hip replacement surgery.Mechanism of Action
Xarelto works by inhibiting Factor Xa, a clotting factor in the body that is responsible for forming blood clots. Xarelto binds to Factor Xa and prevents it from activating. This inhibits the formation of blood clots, thus reducing the risk of stroke and other thromboembolic events.How Long Does It Take To Work?
Xarelto begins working quickly, and the effects can be felt soon after it is taken. However, the exact amount of time it takes to work can vary from person to person, usually being between 2-4 hours.Absorption
Xarelto is rapidly and completely absorbed after oral administration. The peak blood concentrations of rivaroxaban are reached within 2 to 4 hours.Route of Elimination
Xarelto is eliminated primarily through the kidneys by glomerular filtration. A small amount is also eliminated through the feces.Dosage
Xarelto is available as a tablet or an injection, and the dose will depend on the patient’s condition, response to treatment, and other medications taken. Generally, the recommended dose is 10 mg once daily. It is important to take the medication as prescribed by your doctor and not stop taking it without consulting your doctor.Administration
Xarelto should be taken with food. The tablets should be swallowed whole and not chewed or crushed. The injection should be given as an intravenous injection and not a subcutaneous injection.Side Effect
Common side effects of rivaroxaban include: bleeding, stomach pain or discomfort, nausea, headache, dizziness, diarrhea, and rash. Serious side effects are rare but may include: difficulty breathing or swallowing, signs of an allergic reaction (swelling of the face, lips, tongue, or throat; difficulty breathing; hives), and signs of liver problems (yellowing of the skin or eyes, dark urine, itching, loss of appetite, abdominal pain). If you experience any of these serious side effects, seek medical attention immediately.Toxicity
Xarelto overdose can cause a number of symptoms and side effects which include bleeding, dizziness, confusion, nausea, and vomiting. If you or someone you know have taken an overdose, seek medical attention immediately.Precautions
Xarelto may increase the risk of bleeding, especially in the elderly. Before starting treatment with rivaroxaban, tell your doctor if you have a history of bleeding disorders, recent surgery, recent head trauma, or if you are taking any medications that increase the risk of bleeding. Avoid activities that are likely to result in bruising or injury while taking rivaroxaban.Interaction
Xarelto may interact with other medications. Tell your doctor about all medications you are taking, including: antiplatelet and anticoagulant medications, aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), oral contraceptives, and certain antibiotics.Disease Interactions
Xarelto may increase the risk of bleeding in people with certain diseases, including: kidney disease, renal impairment, hepatic failure, severe hypertension, active peptic ulcer disease, and active gastrointestinal bleeding.Drug Interactions
Xarelto may interact with other drugs, including: antiplatelet or anticoagulant medications, aspirin, NSAIDs, oral contraceptives, and certain antibiotics.Food Interactions
Xarelto may interact with food and alcohol. Avoid taking rivaroxaban with high-fat meals, which may reduce the absorption of the drug. Alcohol can increase the risk of bleeding when taken with rivaroxaban.Pregnancy and Lactation Use
Xarelto is not recommended for use in pregnant women unless absolutely necessary. If taken, the dose should be adjusted according to the individual's needs and the benefit-risk assessment should be done by the doctors. Xarelto is not recommended for use in breastfeeding mothers unless absolutely necessary.Acute Overdose
An overdose of rivaroxaban can cause excessive bleeding. Seek immediate medical attention if you think you have taken more than the prescribed amount.Contraindications
Xarelto is contraindicated in patients with active major bleeding, uncontrolled hypertension, and active liver disease.Administration Instructions
Xarelto should be taken with food. The tablets should be swallowed whole and not chewed or crushed. The injection should be given as an intravenous injection and not a subcutaneous injection.Storage Conditions
Xarelto should be stored at room temperature between 68°F and 77°F (20°C and 25°C). Protect from moisture and light. Do not store in the bathroom.Volume of Distribution
Xarelto has a volume of distribution of 5.9 L/kg.Half life
Xarelto has a half-life of 5 to 9 hours.Clearance
Xarelto has a renal clearance of 18.6 L/h.Here you find in details version of Xarelto
Some Frequently Asked Questions About Xarelto
What is Xarelto?
Xarelto is an anticoagulant or "blood thinner" medicine. It works by reducing the blood's ability to form clots and is used to treat and prevent venous thromboembolism (VTE).
Can I buy Xarelto over the counter?
No, Xarelto is a prescription medication and must be obtained from a doctor or pharmacist.
What are the side effects of Xarelto?
Xarelto can cause a number of side effects including headaches, dizziness, fatigue, and bleeding. In rare cases, it can also cause anemia, low blood platelet levels, and liver problems.
What is the recommended dose of Xarelto?
The recommended dose of Xarelto is 10-20 mg taken orally once daily, depending on your individual treatment plan.
What is the most common side effect of Xarelto?
The most common side effect of Xarelto is bleeding. This can be surface level, such as bruises and nosebleeds, or serious internal bleeding.
What if I forget to take a dose of Xarelto?
If you forget to take a dose, take it as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
What should I avoid when taking Xarelto?
You should avoid activities that could increase your risk of bleeding, like taking certain blood thinners such as aspirin or ibuprofen, using sharp objects, or engaging in contact sports. Additionally, you should avoid alcohol and other medications that could interfere with Xarelto.
Is Xarelto safe during pregnancy?
Xarelto has not been studied in pregnant women, so it is not recommended for use during pregnancy. Speak to your doctor if you are considering taking Xarelto while pregnant.
What is the best way to take Xarelto?
It is best to take Xarelto with food and the same time each day to maintain steady levels of the medication. Additionally, be sure to take it with a full glass of water to avoid stomach irritation.
Is Xarelto covered by insurance?
This depends on your insurance provider. Some insurers may cover the cost of Xarelto, while others may not. Speak to your insurance provider to find out if Xarelto is covered.
Can I take other medications while taking Xarelto?
It is important to consult your doctor before taking any medications, including over-the-counter medications. Some medications can interact with Xarelto and cause serious side effects.
What if I miss my dose of Xarelto?
If you miss a dose of Xarelto, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Can Xarelto be used long-term?
Yes, Xarelto can be used on a long-term basis for the prevention of blood clots in certain conditions. Speak to your doctor to find out if Xarelto is an appropriate treatment plan for you.
Does Xarelto cause hair loss?
Hair loss is not a common side effect of Xarelto. However, if you experience any unusual changes in your hair or skin while taking the medication, speak to your doctor.
Can I take aspirin while taking Xarelto?
No, you should not take aspirin while taking Xarelto, as it can increase your risk of bleeding. If you need to take aspirin for other medical conditions, consult your doctor.
Is Xarelto safe for long-term use?
Yes, Xarelto is considered safe for long-term use when taken as directed by your doctor. It is important to speak to your doctor if you have any concerns about taking Xarelto long-term.
Can Xarelto cause liver damage?
In rare cases, Xarelto can cause liver damage. Speak to your doctor or pharmacist immediately if you have any signs or symptoms of liver damage, including nausea, vomiting, dark urine, yellowing of the skin or eyes, or general fatigue.
Can I take ibuprofen while taking Xarelto?
No, you should not take ibuprofen while taking Xarelto, as it can increase your risk of bleeding. If you need to take ibuprofen for other medical conditions, consult your doctor.
Can Xarelto be used to treat high blood pressure?
No, Xarelto is not indicated for the treatment of high blood pressure. Speak to your doctor if you have concerns about your blood pressure or your risk for developing clots.
Does Xarelto cause weight gain?
Weight gain is not a common side effect of Xarelto. However, if you do experience weight gain while taking Xarelto, talk to your doctor.
Is Xarelto safe for older adults?
Yes, Xarelto can be used safely and effectively in older adults. However, it is important to speak to your doctor to ensure it is appropriate for your individual needs and risks.
Does Xarelto put me at a higher risk for bleeding?
Xarelto can increase your risk for bleeding, so it is important to be aware of the signs and symptoms of blood clots and take the medication as directed by your doctor. Speak to your doctor if you have any concerns.
Is Xarelto available in generic form?
No, Xarelto is not available in generic form. However, there are branded generics available on the market.
Does Xarelto interact with birth control?
Yes, Xarelto can interact with some types of birth control, such as the patch, vaginal ring, and implantable contraceptives. Speak to your doctor if you are taking any type of birth control.
Do I need to monitor my blood pressure while taking Xarelto?
Yes, you should monitor your blood pressure while taking Xarelto. Speak to your doctor if you have any concerns about your blood pressure.
Does Xarelto affect fertility?
It is not known if Xarelto affects fertility. Speak to your doctor if you have any concerns about your fertility while taking the medication.
Can Xarelto cause dizziness?
Yes, dizziness is a common side effect of Xarelto. If you experience dizziness while taking the medication, speak to your doctor.
Can Xarelto cause anemia?
In rare cases, Xarelto can cause anemia. If you experience any signs of anemia, such as fatigue, weakness, pale skin, and shortness of breath, speak to your doctor right away.
How long does it take for Xarelto to work?
The effects of Xarelto can vary between individuals, but the effects usually become noticeable within 24 hours of taking a dose. If it does not seem to work, consult your doctor.
Can I drink alcohol while taking Xarelto?
No, it is advised to avoid drinking alcohol while taking Xarelto, as it can increase your risk of bleeding. Speak to your doctor if you have any concerns.
Can I take Xarelto while breastfeeding?
It is not recommended to take Xarelto while breastfeeding. Speak to your doctor to find out if it is an appropriate treatment for you.
Can I take other anticoagulants while taking Xarelto?
No, it is not recommended to take two different anticoagulant medications at the same time. Speak to your doctor if you need to take two different anticoagulant medications.
Does Xarelto cause fatigue?
Yes, fatigue is a common side effect of Xarelto. If you experience unusual or persistent fatigue while taking the medication, speak to your doctor.
Can Xarelto cause mood changes?
Mood changes is not a common side effect of Xarelto. If you experience any mood changes while taking the medication, talk to your doctor.
How long does Xarelto stay in your system?
Xarelto has an elimination half-life of nine to 11 hours. This means it takes approximately nine to 11 hours for the medication to be reduced by half in your body.
How long should I take Xarelto?
The length of your treatment with Xarelto will depend on your individual condition and other factors. Speak to your doctor to find out how long your treatment plan will be.
Can Xarelto be used to treat atrial fibrillation?
Yes, Xarelto can be used to treat atrial fibrillation. Speak to your doctor if you have any questions about using Xarelto for this condition.
Are there any natural alternatives to Xarelto?
There are some natural alternatives that can work to help the body clot blood, such as omega-3 fatty acid supplements, vitamin K, gingko biloba, garlic, feverfew, and nattokinase. However, they should not be used as a substitute for Xarelto and should only be taken under the supervision of a doctor.