Веро-Флутамид

Веро-Флутамид Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Веро-Флутамид is a brand name. Its generic name is Flutamide.

Introduction

Веро-Флутамид is an oral synthetic, non-steroidal antiandrogen used in the treatment of prostate cancer and hyperandrogenic conditions. It has a number of trade names, including Eulexin and Flutamid.

Uses for

Веро-Флутамид is used in the treatment of prostate cancer, hirsutism, and benign prostatic hyperplasia, where it helps block the action of androgens, such as testosterone, which can cause or worsen these conditions. It is also used in combination with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of metastatic prostate cancer.

Mechanism of Action

Веро-Флутамид works by binding to and blocking androgen receptors, thus preventing androgens from binding to these receptors and exerting their effects. This prevents the action of hormones like testosterone, which can cause prostate cancer to grow.

How Long Does it Take to Work

Веро-Флутамид typically takes 2 to 4 weeks to start working properly. The full effects of the medication may take up to 6 months to become apparent.

Absorption

Веро-Флутамид is rapidly and completely absorbed from the gastrointestinal tract with peak plasma concentrations reached 1 to 4 hours after administration. The bioavailability of the drug is about 98%.

Route of Elimination

Веро-Флутамид is extensively metabolized, both by sulfation and glucuronidation in the liver. The metabolites are excreted mainly in the urine and feces. The elimination half-life is approximately 6 hours.

Dosage

The recommended dosage of Веро-Флутамид in adults is 250mg to 500mg three times a day. In cases of metastatic prostate cancer, the recommended dosage is 750mg to 1500mg per day.

Administration

Веро-Флутамид is administered orally in tablet form. It should be taken with food, preferably a fat-rich meal, to increase absorption. Tablets should not be crushed or broken.

Side Effect

Common side effects of Веро-Флутамид include impotence, breast tenderness or enlargement, nausea, vomiting, decreased libido, headache, and hot flashes. Rarely, Веро-Флутамид may cause jaundice, hepatotoxicity, and gynecomastia (breast enlargement in males).

Toxicity

Веро-Флутамид is generally well tolerated with few serious side effects. However, high doses and long-term use may increase the risk of hepatotoxicity. Patients should be monitored for signs of liver toxicity. If any signs or symptoms of liver damage occur, the medication should be stopped immediately.

Precaution

It is important to inform your physician and pharmacist of any medications you are currently taking or plan to take to prevent potential drug interactions. Also be aware that certain conditions, such as diabetes, heart disease, and liver or kidney problems may alter your sensitivity to Веро-Флутамид.

Interaction

Веро-Флутамид may interact with other medications such as ketoconazole, spironolactone, and ampicillin. Therefore, it is important to inform your physician and pharmacist of any medications you are currently taking or plan to take to prevent potential drug interactions.

Disease Interaction

Веро-Флутамид may interact with certain medical conditions. Patients with liver or kidney disease should use Веро-Флутамид with caution. Be sure to inform your healthcare provider of any existing or past health conditions prior to taking Веро-Флутамид.

Drug Interaction

Medicines such as warfarin, ketoconazole, and spironolactone may interact with Веро-Флутамид. Be sure to inform your doctor and pharmacist of any medications that you are taking or plan to take in order to avoid any potential drug interaction.

Food Interaction

Веро-Флутамид should be taken with a fat-rich meal such as a cheese sandwich or yogurt to increase absorption. Do not drink alcohol while taking this medication.

Pregnancy Use

Веро-Флутамид should not be taken by pregnant women as it could cause harm to the fetus. Women of child bearing age should take appropriate measures to prevent pregnancy during treatment with Веро-Флутамид.

Lactation Use

It is not recommended to use Веро-Флутамид when breastfeeding as it may be transferred in breast milk and may harm the baby. Women of child bearing age should take appropriate measures to prevent pregnancy during treatment with Веро-Флутамид.

Acute Overdose

An acute overdose of Веро-Флутамид may cause nausea, vomiting, abdominal pain, dizziness, and drowsiness. If any of these symptoms occur, the person should seek immediate medical attention.

Contraindication

Patients who are pregnant or have a history of liver disease, kidney disease, or hypersensitivity to Веро-Флутамид should not take this medication. There are potential drug interactions with some antibiotics, antifungals, and anticoagulants, so be sure to inform your doctor and pharmacist of any medications you are currently taking or plan to take while taking Веро-Флутамид.

Use Direction

It is important to take Веро-Флутамид exactly as prescribed by your doctor. If a dose is missed, take the missed dose as soon as possible. Do not take two doses at once, and do not take more than the prescribed dose. Do not stop taking this medication without consulting your doctor first.

Storage Condition

Веро-Флутамид should be stored at room temperature, in an airtight container, and away from light, moisture, and heat. Do not keep Веро-Флутамид for longer than 6 months.

Volume of Distribution

The apparent volume of distribution of Веро-Флутамид in humans is approximately 200 liters.

Half Life

Веро-Флутамид has a half-life of approximately 6 hours.

Clearance

The clearance of Веро-Флутамид in humans is approximately 25 ml/min.

Here you find in details version of Веро-Флутамид

Some Frequently Asked Questions About Веро-Флутамид

What is Веро-Флутамид?

Веро-Флутамид is a non-steroidal antiandrogen medication that is used to treat certain prostate cancer in men.

How does Веро-Флутамид work?

Веро-Флутамид works by blocking testosterone from attaching to androgen receptors and, in turn, stops testosterone from stimulating tumor cell growth. It is thought to work primarily by competing with testosterone and dihydrotestosterone for binding at androgen receptors.

What are the uses of Веро-Флутамид?

Веро-Флутамид is used to treat prostate cancer in conjunction with other traditional cancer treatments. It is also being studied for potential applications in other hormone-dependent medical conditions such as endometriosis and acne.

Who can take Веро-Флутамид?

Веро-Флутамид is approved to be taken by adult men 18 years and over who have an advanced form of prostate cancer. It should not be taken by women or children.

How is Веро-Флутамид taken?

Веро-Флутамид is available in the form of capsules. It is usually taken in combination with other prostate cancer treatments, such as surgery and radiation. It is usually taken three times a day, with meals.

What are the side effects of Веро-Флутамид?

Common side effects of Веро-Флутамид include weight loss, diarrhea, nausea, vomiting, and headaches. However, the most serious possible side effect are liver injury, so it is important to get regular blood tests to check for liver function.

Are there any interactions with Веро-Флутамид?

You should always check with your doctor before taking any medications or herbal supplements, as some of them could interact with Веро-Флутамид, such as barbituates, rifampin, and St. John's Wort. Additionally, alcohol can make some of the side effects from Веро-Флутамид worse.

Does Веро-Флутамид treat benign prostatic hyperplasia?

No, Веро-Флутамид is not used to treat benign prostatic hyperplasia (BPH). BPH is a common, noncancerous enlargement of the prostate gland. It is often treated with a combination of lifestyle changes and different types of medications.

Does Веро-Флутамид cause hair loss?

Yes, hair loss is a common side effect reported with Веро-Флутамид. However, it is usually temporary and is reversed once the medication is stopped.

Is Веро-Флутамид available in generic form?

Yes, the generic name for Веро-Флутамид capsules is flutamide. It is available in various strengths and compositions.

How long does it take for Веро-Флутамид to start working?

Веро-Флутамид works by blocking the effects of testosterone, so it may take several weeks or months for its effects to take place. It is important to follow your doctor's instructions and continue taking Веро-Флутамид even if you don't see immediate results. Your doctor may monitor you closely with regular blood tests.

Does Веро-Флутамид cause weight gain?

No, weight gain is not a common side effect of Веро-Флутамид. However, it is possible that weight loss may occur due to its other side effects, such as nausea and vomiting.

Can Веро-Флутамид be used to treat endometriosis?

Yes, Веро-Флутамид is being studied for potential applications in treating endometriosis. However, it is still under investigation and is currently not approved for use in this condition.

Are there any alternatives to Веро-Флутамид?

Yes, there are several other medications which are used as alternatives to Веро-Флутамид, such as bicalutamide, nilutamide, and cyproterone acetate. Your doctor can help you decide which medication would be best for you.

Will Веро-Флутамид stop my cancer from growing?

Веро-Флутамид is not a cure for prostate cancer. However, it can help slow the growth of the tumor by blocking testosterone from attaching to androgen receptors. It should be used in combination with other traditional cancer treatments such as surgery and radiation.

Can I still exercise and play sports while taking Веро-Флутамид?

Yes, you can continue to participate in physical activity while taking Веро-Флутамид. However, if you experience any new or worsening symptoms while exercising, such as dizziness or chest pain, you should stop and contact your doctor.

Are there any dietary restrictions I should follow while taking Веро-Флутамид?

There are no specific dietary restrictions you should follow while taking Веро-Флутамид. However, it is always wise to follow a well-balanced, nutritious diet to help manage your condition.

What should I do if I miss a dose of Веро-Флутамид?

If you miss a dose of Веро-Флутамид, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue on your regular schedule. Do not take a double dose to make up for a missed one.

What should I do if I overdose on Веро-Флутамид?

If you think you have taken too much Веро-Флутамид, contact your doctor or local poison control center immediately. Overdose symptoms of Веро-Флутамид include nausea, vomiting, and drowsiness.

Is Веро-Флутамид safe to use during pregnancy?

No, Веро-Флутамид should not be used during pregnancy. It can cause harm to a developing baby and can pass into breastmilk, so it is important for women to let their doctor know if they are pregnant or breastfeeding.

Can Веро-Флутамид affect my fertility?

Yes, taking Веро-Флутамид can affect fertility in men. It is important to talk to your doctor about possible fertility options if you hope to father a child in the future.

Does Веро-Флутамид interact with other medications?

Yes, Веро-Флутамид can interact with other medications. Make sure to discuss with your doctor if you are taking any other medications, including over-the-counter drugs and herbal supplements, to avoid any potentially dangerous interactions.

What should I watch out for while taking Веро-Флутамид?

It is important to follow your doctor's instructions while taking Веро-Флутамид and to contact your doctor if you experience any new or worsening symptoms. Additionally, you should have regular blood tests to monitor your liver function while on this medication.

How long does it take for Веро-Флутамид to be removed from the body?

It takes approximately 5 hours for Веро-Флутамид to be completely eliminated from the body. However, it may take longer in some individuals.

Is Веро-Флутамид safe for long-term use?

Веро-Флутамид is generally safe for long-term use, however it is important to follow your doctor's instructions and have regular check-ups to monitor your liver function.

What else should I know about Веро-Флутамид?

Веро-Флутамид may cause drowsiness or dizziness, so it is important to not operate heavy machinery or drive while taking this medication. Additionally, it should not be taken with alcohol, as it can worsen some of the side effects.

Is there a generic version of Веро-Флутамид?

Yes, the generic version of Веро-Флутамид is called flutamide and is available in various strengths.

Can I take Веро-Флутамид if I have liver disease?

Веро-Флутамид can cause liver injury, so it is important to talk to your doctor if you have any pre-existing liver conditions. Your doctor can help determine if Веро-Флутамид is the right medication for you.

What happens if I suddenly stop taking Веро-Флутамид?

You should not suddenly stop taking Веро-Флутамид without talking to your doctor. Sudden discontinuation of this medication may cause the cancer to start growing again. Your doctor may decrease the dose of the medication gradually to reduce the risk of side effects.

Does Веро-Флутамид lower testosterone levels?

Yes, Веро-Флутамид works by blocking testosterone from binding to androgen receptors. This can lead to a decrease in testosterone levels in the body.

Does Веро-Флутамид help with acne?

Yes, Веро-Флутамид is being studied for potential applications in treating certain types of acne. However, it is not currently approved for this use.

Can Веро-Флутамид be taken with food?

Yes, Веро-Флутамид can be taken with food. Taking the medication with food can help reduce the chance of stomach upset.

What should I do if I experience side effects from Веро-Флутамид?

If you experience any side effects from taking Веро-Флутамид, it is important to contact your doctor as soon as possible. Your doctor may adjust the dosage or recommend alternative treatments.

Is Веро-Флутамид safe to take with other cancer treatments?

Yes, Веро-Флутамид is often used in combination with other cancer treatments. However, it is important to discuss all of your medications and treatments with your doctor in order to reduce any potential interactions.

How does Веро-Флутамид compare to other prostate cancer medications?

Веро-Флутамид is similar to bicalutamide, nilutamide, and cyproterone acetate in that it is a non-steroidal antiandrogen medication used to treat prostate cancer. However, each of these medications work differently and may be more or less effective depending on the individual.

Can Веро-Флутамид cause hair growth?

No, Веро-Флутамид does not cause hair growth. In fact, it is commonly associated with hair loss as one of its side effects. However, this is usually temporary and reversed once the medication is stopped.

Does Веро-Флутамид cause fatigue?

Yes, fatigue is a common side effect reported with Веро-Флутамид. If you experience this side effect, it is important to contact your doctor so that your dose can be adjusted, if necessary.