Varithena
Varithena Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Varithena is a brand name. Its generic name is Polidocanol.
Varithena
Varithena, also known as lauryl alcohol, is a sclerosing agent used in medical treatments. It is chemically known as N-dodecyl-p-hydroxybenzenesulfonamide. It is an amphiphilic compound that typically mixes with water in the form of micelles. It is non-toxic at low doses and is used in cosmetic preparations such as shampoos, conditioners, and hand creams.
Uses For
Varithena is used to treat the following conditions: varicose veins, haemorrhoids, lymphoedema, telangiectasias, and solvent for cutaneous injections. It is also used in post-surgical wound healing.
Mechanism of Action
Varithena acts by creating an irritation in the targeted area, thus causing an inflammatory reaction. This reaction shrinks the walls of the affected veins or blood vessels, causing them to collapse and block the flow of blood. Ultimately, this stops swelling and improves the appearance of the affected area.
How Long Does It Take to Work?
Depending upon the severity of the condition, it can take anywhere from a few days to several weeks to observe the effects of Varithena treatment. For varicose veins or haemorrhoids, it generally takes 1-6 weeks to notice the full effects.
Absorption
Varithena is quickly and almost completely absorbed by the skin and is generally not affected by the presence of proteins. It has both local and systemic effects.
Route of Elimination
Varithena is metabolized in the liver and primarily excreted in the urine.
Dosage
Varithena is usually administered through injections into the tissue or vein. Depending on the severity of the condition being treated, the dosage of Varithena may vary from 0.25% to 2%.
Administration
Varithena is typically administered through injections. It is also available in cream and ointment formulations.
Side Effect
Common side effects of Varithena include irritation and swelling at the injection site, bruising, redness, or numbness. Other more serious side effects may include infection, soreness, or allergic reactions.
Toxicity
Varithena is generally safe when used in the recommended doses. In rare cases, excessive use may cause anaphylactic shock or other systemic reactions.
Precaution
Varithena should not be used in patients who are pregnant or breastfeeding, or have a history of allergic reactions to similar compounds. It should also be avoided in patients with any vascular diseases. Before using Varithena, it is important to report any and all medications and supplements that the patient may be taking.
Interaction
Varithena may interact with other medications, herbs, or supplements that the patient is taking. Before administering Varithena, it is important to inform the patient about all medications, herbs, and supplements that they may be taking.
Disease Interaction
Varithena may interact with certain diseases such as diabetes, hypertension, heart disease, and liver disease. Before administering Varithena, it is important to inform the patient about any and all diseases that they may have.
Drug Interaction
Varithena may interact with certain drugs such as blood thinners, anticoagulants, anti-inflammatory medications, antibiotics, and antifungal medications. It is important to inform the patient about all medications that they may be taking prior to administering Varithena.
Food Interactions
Varithena does not interact with food or beverages. However, it may interact with certain foods, such as those containing high levels of Vitamin K, which can increase the risk of bleeding.
Pregnancy Use
Varithena should be avoided during pregnancy as it may be harmful to the developing fetus.
Lactation Use
Varithena is not recommended for use while breastfeeding as it may pass into breast milk and cause harm to the nursing infant.
Acute Overdose
No acute overdose of Varithena has been reported. However, if an overdose occurs, it is important to seek immediate medical attention.
Contraindication
Varithena is contraindicated in patients with inflammatory bowel disease, bleeding disorders, and any other condition in which a sclerosing agent is not recommended.
Use Direction
Varithena should be used as directed by the healthcare provider, as dosage may vary depending on the condition and individual patient. Injections of Varithena should be made only into the affected areas. Creams and ointments should be applied directly to the affected area.
Storage Condition
Varithena should be stored in a cool and dry place, away from direct sunlight. It is important to keep polidocanol and all other medications out of reach of children and pets.
Volume of Distribution
The volume of distribution for Varithena is approximately 1.28 L/kg.
Half Life
The elimination half-life of Varithena is approximately 0.76 hours.
Clearance
The clearance rate for Varithena is approximately 3.7 ml/min/kg.
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