Vasoclear
Vasoclear Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Vasoclear is a brand name. Its generic name is Naphazoline.
Vasoclear
Vasoclear is a decongestant and vasoconstrictor used to relieve redness, swelling, and itching caused by irritation or inflammation of the eyes. It belongs to a group of medications called sympathomimetic amines and primarily acts by reducing the size of blood vessels in the nasal and conjunctival membranes. It can also be used to help alleviate symptoms of colds and hay fever. Vasoclear is available in both oral and topical forms.
Uses for
Vasoclear is mainly used for the temporary relief of redness, burning, itching, and other discomforts of the eyes caused by pollen, dust, animal dander, air pollution, or other irritants. It is also used for the temporary relief of burning and irritation caused by exposure of the eyes to wind or alien objects like dirt, sand, and other particles.
Mechanism of Action
Vasoclear works by constricting the blood vessels in the nasal and conjunctival membranes. This reduces the irritation and inflammation associated with allergies, colds, and hay fever. Furthermore, naphazoline also exhibits a decongestant and astringent properties, which help shrink the membranes and reduce the swelling.
How Long Does It Take To Work?
Vasoclear usually works within minutes after topical application or oral administration. However, the effects may vary depending on the individual.
Absorption
Vasoclear is quickly and completely absorbed into the systemic circulation following oral administration. After topical administration, naphazoline is absorbed into the systemic circulation through the mucous membranes of the eye.
Route of Elimination
Vasoclear is metabolized in the liver and excreted in the urine. The drug exhibits a half-life of 1.2 to 1.5 hours.
Dosage
Vasoclear dosage may vary depending on the severity of the condition, age, and other factors. The typical dosage for adults is one to two drops of the eye solution in the affected eye four times a day or one to two tablets taken orally two to three times a day. The eye drops may also be used on an as-needed basis. It is important to consult a doctor before using naphazoline in order to determine the correct dosage.
Administration
Vasoclear is available as eye drops for topical administration and tablets for oral administration.
Side Effect
Common side effects associated with the use of naphazoline include stinging of the eyes, blurred vision, increased sensitivity to light, a dry mouth, dizziness, and lightheadedness. In some cases, naphazoline may cause serious side effects like rapid and/or irregular heartbeat, chest pain, confusion, difficulty breathing, and fainting. It is important to consult a doctor if any of these symptoms occur.
Toxicity
Prolonged or excessive use of naphazoline may lead to systemic toxicity, which can result in serious side effects such as hypertension, hypokalemia, and cardiac arrhythmia. Signs of systemic toxicity may include headache, palpitations, restlessness, nervousness, tremor, weakness, and dizziness. It is important to contact a doctor immediately if any of these symptoms occur.
Precaution
Vasoclear should be used with caution in individuals with pre-existing conditions like high blood pressure, diabetes, kidney or liver problems, and thyroid disorders. It is also important to avoid using topical ophthalmic products containing naphazoline while wearing contact lenses. Additionally, caution should be exercised when using naphazoline in elderly patients.
Interaction
Vasoclear may interact with certain medications such as beta blockers, ACE inhibitors, MAO inhibitors, tricyclic antidepressants, and diuretics. Additionally, the absorption of naphazoline may be reduced when taken with food or antacids. Therefore, it is important to inform the doctor about all medicines the patient is taking before beginning treatment with naphazoline.
Drug Interaction
Vasoclear may increase the effects of certain medications such as decongestants, antihistamines, epinephrine, amphetamines, antidepressants, and some antihypertensive drugs. Additionally, it may interact with drugs that act on the central nervous system and alcohol, which can increase the risk of side effects. Therefore, it is important to inform the doctor about all medications the patient is taking before beginning treatment with naphazoline.
Food Interactions
Vasoclear may interact with certain foods and drinks. It is important to inform the doctor of all foods and drinks the patient is consuming during treatment with naphazoline. Additionally, naphazoline may affect the absorption of other medications taken orally, so it is important to avoid taking other medications shortly before or after taking naphazoline.
Pregnancy Use
Vasoclear has been assigned to FDA Pregnancy Category C. Animal studies have shown that naphazoline is teratogenic, but no adequate and well-controlled studies have been conducted in pregnant women. It is important to consult a doctor before using naphazoline during pregnancy.
Lactation Use
It is not known whether naphazoline is excreted into breast milk. Therefore, it is important to consult a doctor before using naphazoline during lactation.
Acute Overdose
In case of an overdose, it is important to seek medical attention immediately. Symptoms of an overdose may include headache, nausea, vomiting, dizziness, restlessness, confusion, blurred vision, dry mouth, and abdominal pain.
Contraindication
Vasoclear should not be used in individuals with known hypersensitivity to its components. It should also be avoided in individuals with glaucoma, impaired cardiovascular function, prostatic hypertrophy, hyperthyroidism, and narrow-angle glaucoma. Additionally, naphazoline should not be used in individuals with hypertension.
Use Direction
Vasoclear should only be used as prescribed by a doctor. It should not be used for longer than 3 days in the case of eye drops, and not more than 10 days for oral dosage forms. In case of contact with the eyes, it is important to rinse thoroughly with plenty of water. Additionally, it is important to store naphazoline at room temperature away from heat and direct light.
Storage Condition
Vasoclear should be stored away from heat and direct light at room temperature. It should not be kept in the refrigerator or freezer.
Volume of Distribution
Vasoclear is highly lipophilic and is widely distributed in tissue. The volume of distribution of naphazoline is approximately 4.5L/kg.
Half Life
The elimination half-life of naphazoline ranges from 1.2 to 1.5 hours following intravenous, oral, and rectal administration.
Clearance
Vasoclear is metabolized in the liver and eliminated in the urine. Its clearance rate is approximately 0.8L/min.
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