Variquel

Variquel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Variquel is a brand name. Its generic name is Terlipressin.

Variquel Introduction

Variquel is an injectable medicine, otherwise known as a vasopressin analog which is derived from the hormone vasopressin. Variquel is primarily used to treat hepatorenal syndrome, a condition which causes deterioration of renal function in liver cirrhosis.

Uses for Variquel

Variquel has multiple uses for treatment of several medical conditions, including the prevention of further harm from hemorrhage due to portal hypertension, treatment of hepatorenal syndrome and esophageal variceal bleeding in cirrhosis and protective effect on mitochondrial function in shock, hepatic or renal dysfunction.

Mechanism of Action

Variquel works by imitating the action of the hormone vasopressin. It helps reduce blood pressure in the portal vein and stimulates the contraction of the small vessels, allowing for a better circulation of blood. It also increases the urinary excretion of sodium and water and increases blood flow to the kidneys, which improves renal function.

How long does it take to work?

It usually takes several hours for Variquel to take effect, however, it can vary depending on the individual. Generally, it should take effect within 24 hours of administration.

Absorption

Variquel is well absorbed from the injection site. After 5 minutes of administration, the maximum absorption of Variquel is achieved.

Route of Elimination

Variquel is eliminated mainly via the renal route, with only a small percentage being eliminated through the biliary route.

Dosage

The recommended dosage of Variquel depends on the individual's medical condition, bodyweight and other factors. The recommended dosage for adults is 1-2 mg intravenously every 6-8 hours or as deemed necessary by the physician. For children under the age of 12, the recommended dosage is 0.1 mg/kg intravenously every 6-8 hours or as prescribed by the physician.

Administration

Variquel should be administered via intravenous injection or infusion. Depending on the medical condition, Variquel can be administered as a single-dose or as a continuous infusion over several hours. It is important to closely follow the instructions of the physician when administering Variquel.

Side-effect

Common side effects of Variquel include nausea, vomiting, headache, abdominal pain, injection site reactions, flushing and low blood sodium (hyponatremia). Other side effects can include increased heart rate, hypotension, chest pain, hypertension, acidosis and dizziness.

Toxicity

Variquel is generally considered safe if used as directed. However, in rare cases, overdose may occur, which can lead to severe side effects such as cardiovascular collapse, respiratory depression, coma, and arrhythmias. It is important to follow the instructions of a physician when taking this medication.

Precaution

It is important to follow the instructions of a physician when administering this medication. Patients with cirrhosis, congestive heart failure, renal impairment or hypotension should use Variquel with caution. Patients should inform their doctor of any medication they are taking as Variquel may interact with other drugs or conditions.

Interaction

Variquel can interact with certain medications or other medical conditions, causing increased or decreased effectiveness. Patients should speak to their physician about any medications they are taking in order to avoid potential adverse reactions. It is also important for patients to inform their doctor of any existing medical conditions, such as cardiac, renal or hepatic disease, as these may interact with the effectiveness of Variquel.

Disease Interaction

Some diseases can interact with or alter the effectiveness of Variquel. Patients with history of cardiac, renal or hepatic disease, should speak to their doctor before taking Variquel as it may not be the safe choice for them. Patients with glucose-6-phosphate dehydrogenase deficiency should also avoid taking Variquel as it could predispose them to significant haemolysis.

Drug Interaction

Drug interactions can cause serious side effects and often increase or decrease the effectiveness of Variquel. It is important to speak to your doctor about all medications and supplements you are taking in order to avoid potential drug interactions. Some medications known to interact with Variquel include diuretics, lithium, ACE inhibitors and other vasopressors.

Food Interactions

It is important to speak to your doctor or pharmacist about any dietary restrictions or allergies you may have when taking Variquel. Some foods may interact with Variquel and decrease its effectiveness, so it is important to find out what food items to avoid when taking this medication.

Pregnancy Use

Variquel is not recommended for use during pregnancy, as it has not been studied yet in pregnant women. It is advised that pregnant women should only take Variquel if it is considered absolutely necessary by the doctor.

Lactation Use

It is not known whether Variquel passes into human milk, so it is advised that breastfeeding mothers should speak to their doctor before taking this medication.

Acute Overdose

If an overdose of Variquel occurs, it is important to seek immediate medical attention. Symptoms of an overdose include nausea, vomiting, dizziness, low blood pressure, low blood sodium levels, rapid heart rate, coma and even death.

Contraindication

Variquel should not be used by patients who are allergic to it or any other ingredients in the medication. It should also not be used by patients with cardiac or renal disease, congestive heart failure, hypotension, and hyponatremia.

Use Direction

It is important to follow the dosage instructions given by your doctor when taking Variquel. The dosage and frequency of use may vary depending on the individual and the medical condition. The medication should be used as instructed by your doctor or pharmacist.

Storage Condition

Variquel should be stored at room temperature and should not be kept in direct sunlight or in extremely hot or cold temperatures. It should also be kept away from children and pets.

Volume of Distribution

The volume of distribution of Variquel is approximately 10L-12L/kg.

Half-Life

The elimination half-life of Variquel is approximately 45 minutes.

Clearance

The clearance rate of Variquel is approximately 1.1 L/h/kg.

Here you find in details version of Variquel

Some Frequently Asked Questions About Variquel

What is Variquel?

Variquel is a synthetic analog of the natural hormone vasopressin. It is used to treat bleeding esophageal varices, a type of bleeding in the esophagus caused by high pressure in the veins of the esophagus.

How does Variquel work?

Variquel works by constricting the veins found in the walls of the esophagus, which helps to reduce the pressure in the veins and stop the bleeding. This constriction also helps reduce the risk of further bleeding.

How is Variquel administered?

Variquel is usually administered constantly through a vein (intravenous) infusion or as an injection directly into the bloodstream (intramuscular).

What are the side effects of Variquel?

The most common side effects of Variquel are headache, dizziness, nausea, vomiting, and constipation. Less common side effects include low blood pressure, chest pain, difficulty breathing, changes in heart rate, and changes in blood sugar levels.

What precautions should be taken before taking Variquel?

Variquel should not be used in patients with any condition affecting the liver or kidneys, or those who are pregnant or breastfeeding. Patients should also discuss any existing medical conditions they have with their healthcare provider before taking Variquel.

Can Variquel be used in combination with other medications?

Variquel should not be taken in combination with any other medications without first consulting a doctor. Some medications may interact with Variquel and cause serious side effects.

Is it safe to use Variquel during pregnancy?

Variquel should not be used during pregnancy as it may cause serious harm to the fetus. Women who are pregnant or planning to become pregnant should discuss any risks with their doctor before taking Variquel.

What is the recommended dosage for Variquel?

The recommended dose of Variquel varies depending on the patient's individual needs. Patients should follow their doctor's instructions and take the medication as directed.

Should patients with heart or kidney problems take Variquel?

Patients with heart or kidney problems should be cautious when taking Variquel and should discuss any potential risks with their doctor before taking it. It is recommended that patients with heart or kidney problems be closely monitored while taking Variquel.

What should be done if an overdose of Variquel occurs?

If an overdose of Variquel is suspected, patients should seek medical help immediately. Treatment will depend on the severity of the overdose and may include hospitalization and supportive care.

Can Variquel be used long-term?

Variquel can be used long-term, but it is important to discuss any potential risks and benefits with a doctor. Some patients may be at greater risk for side effects or other complications when taking the medication long-term.

Is Variquel available in generic form?

No, Variquel is not available in generic form. It is available as a brand-name medication only.

Is Variquel available over-the-counter?

No, Variquel is not available over-the-counter. It is available by prescription only.

What is the cost of Variquel?

The cost of Variquel varies depending on the pharmacy and the dosage needed. Patients should check with their insurance plan to determine what their coverage is for Variquel.

Does Variquel increase the risk of bleeding?

No, Variquel does not increase the risk of bleeding. In fact, it helps reduce the risk of further bleeding by reducing pressure in the veins of the esophagus.

Does Variquel need to be taken regularly?

Yes, Variquel needs to be taken regularly in order to be effective. Patients should follow their doctor's instructions for taking the medication in order to achieve the best results.

How often does Variquel need to be taken?

The frequency of taking Variquel depends on the individual's condition and dosage prescribed by their doctor. In general, patients are advised to take Variquel twice daily for best results.

Does Variquel increase blood pressure?

No, Variquel does not increase blood pressure. In fact, it helps reduce pressure in the veins of the esophagus and may lower blood pressure.

Do patients need to change their diet while taking Variquel?

It is not necessary for patients to change their diet while taking Variquel, but it is recommended that they limit their intake of alcohol and caffeine. Patients should talk to their doctor about other dietary changes that may be beneficial.

Can Variquel be used in children?

No, Variquel is not recommended for use in children due to potential side effects. Parents should consult with their doctor before giving Variquel to their child.

Is Variquel safe for long-term use?

Long-term use of Variquel is generally safe but may cause certain side effects or other complications. It is important to talk to a doctor about the potential risks and benefits of long-term use.

What is the recommended storage of Variquel?

Variquel should be stored at room temperature away from direct light and moisture. It should not be exposed to extreme temperatures or stored in the refrigerator.

Are there any alternatives to Variquel?

Yes, there are several alternative treatments available for treating bleeding esophageal varices, such as endoscopic treatments and surgical treatments. Patients should talk to their doctor about the pros and cons of the various alternatives.

Can Variquel interact with other medications?

Yes, Variquel can potentially interact with certain medications, including those taken for diabetes, high blood pressure, or kidney or liver conditions. It is important to tell a doctor about all medications and supplements being taken before starting Variquel.

What is the most common side effect of Variquel?

The most common side effect of Variquel is headache. Other common side effects include dizziness, nausea, vomiting, and constipation.

Does Variquel need to be taken with food?

No, Variquel does not need to be taken with food. However, some patients may feel an increased sense of nausea if the medication is taken on an empty stomach.

Does Variquel cause dehydration?

No, Variquel does not typically cause dehydration. However, it is important to drink plenty of fluids while taking the medication to avoid dehydration.

Can Variquel cause dizziness?

Yes, Variquel can cause dizziness. Patients who experience dizziness should consult with their doctor before continuing to take the medication.

Does Variquel affect heart rate?

Yes, Variquel can affect heart rate. Patients who have heart conditions or a history of cardiac arrhythmia should discuss any potential risks before starting on Variquel.

Can Variquel cause low blood pressure?

Yes, Variquel can cause low blood pressure. Patients who are at increased risk of low blood pressure should discuss potential risks with their doctor before taking Variquel.

Does Variquel cause fatigue?

Yes, Variquel can cause fatigue in some patients. Patients who experience fatigue should discuss this with their healthcare provider to determine if an adjustment in the dosage is necessary.

What should be done if Variquel is missed?

If a dose of Variquel is missed, the patient should take it as soon as possible. However, if the missed dose is close to the next scheduled dose, the patient should skip it and take the next scheduled dose as normal.

Does Variquel cause weight gain?

No, Variquel does not typically cause weight gain. However, some patients may experience an increase in appetite while taking the medication.

Does Variquel cause dry mouth?

Yes, Variquel can cause dry mouth in some patients. Patients can ensure they stay hydrated and drink plenty of fluids to help alleviate this side effect.

Can Variquel cause changes in mood or behavior?

Yes, Variquel can cause mood swings or behavioral changes in some patients. If changes in mood or behavior occur, patients should consult with their doctor for an evaluation.

Can Variquel cause changes in blood sugar levels?

Yes, Variquel can cause changes in blood sugar levels. Patients with diabetes should closely monitor their blood sugar while taking this medication.

Does Variquel cause bloating or digestive issues?

Yes, Variquel can cause bloating and digestive issues in some patients. If these side effects occur, patients should talk to their doctor about alternative treatments.

Is Variquel safe for use in patients with liver disease?

No, Variquel is not recommended for use in patients with liver disease. Patients with liver disease should discuss other options with their doctor before taking the medication.

Does Variquel increase the risk of blood clots?

No, Variquel does not increase the risk of blood clots. Patients with a history of blood clots should discuss this with their doctor before taking Variquel.

Can Variquel cause abnormal urine color?

Yes, Variquel can cause abnormal urine color in some patients. Patients should contact their doctor if they notice any changes in the color of their urine.