Valus P

Valus P Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Valus P is a brand name. Its generic name is Parecoxib.

Introduction

Valus P is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It is typically prescribed in combination with other medications for treating osteoarthritis and rheumatoid arthritis.

Uses

Valus P is used to treat pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It is typically prescribed in combination with other medications for treating osteoarthritis and rheumatoid arthritis.

Mechanism of Action

Valus P works by blocking the enzyme cyclooxygenase-2 (COX2), which is responsible for producing prostaglandins (chemicals that cause pain and inflammation). This explains its anti-inflammatory effects.

How Long Does it Take to Work

Valus P typically takes 1 to 2 hours to start working and its effects can last up to 8 hours.

Absorption

Valus P is rapidly and completely absorbed after oral administration.

Route of Elimination

Valus P is eliminated primarily in the urine, with renal clearance accounting for about 70% of the dose. The remainder is metabolized in the liver.

Dosage

The usual dose of Valus P for adults is 40 mg, taken twice a day. Your doctor may prescribe you a lower dose if you have kidney or heart-related conditions.

Administration

Valus P should be taken orally with a full glass of water.

Side Effects

Common side effects of Valus P include nausea, diarrhea, headaches, dizziness, rash, gas, and upset stomach.

Toxicity

Valus P is generally safe and well tolerated when used at recommended doses. However, taking higher doses or long-term use of Valus P increases the risk of serious side effects such as heart attack, stroke, and intestinal bleeding.

Precautions

Patients taking Valus P should avoid alcohol consumption and smoking. You should also inform your doctor if you have any heart, liver, or kidney problems before taking Valus P.

Interactions

Valus P can interact with other drugs, such as warfarin, ACE inhibitors, methotrexate, and diuretics. You should always inform your doctor about any medications you are taking before starting Valus P.

Disease Interactions

Valus P should be used with caution in patients with a history of heart disease, stroke, or bleeding disorders. Valus P may also increase the risk of fluid retention or edema in patients with kidney or liver diseases.

Drug Interactions

Valus P may interact with other drugs such as warfarin, ACE inhibitors, methotrexate, and diuretics. You should always inform your doctor about any medications you are taking before starting Valus P.

Food Interactions

Taking Valus P with certain foods may decrease its absorption. It is important to take Valus P on an empty stomach or at least two hours after a meal.

Pregnancy Use

Valus P is not recommended for use in pregnant women. It may cause harm to the unborn baby.

Lactation Use

It is not known whether Valus P is excreted in human milk. Therefore, it is not recommended for use in breastfeeding women.

Acute Overdose

An overdose of Valus P can cause symptoms such as nausea, vomiting, stomach pain, and diarrhea. If an overdose is suspected, seek immediate medical attention.

Contraindication

Valus P is contraindicated in patients with a known allergy to this medication, as well as in patients with severe bleeding disorders, severe liver or kidney impairment, or recent history of stroke or heart attack.

Use Direction

Valus P should be used as directed by your physician. Your doctor may adjust the dosage as needed based on your weight, severity of your condition, and other medical conditions you may have.

Storage Condition

Valus P should be stored at room temperature, protected from light and moisture.

Volume of Distribution

The volume of distribution of Valus P is 84 L, meaning that the drug distributes well throughout the body's tissues.

Half Life

Valus P has a half-life of approximately 7 hours.

Clearance

The clearance of Valus P is mainly by the kidney, with renal clearance accounting for about 70% of the dose. The remainder is metabolized in the liver.

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