Tivonum
Tivonum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tivonum is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Tivonum (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Tivonum is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Tivonum works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Tivonum can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Tivonum is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Tivonum is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Tivonum is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Tivonum should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Tivonum may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Tivonum use, however it can cause serious side effects in certain individuals.Precautions
- Tivonum should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Tivonum may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Tivonum should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Tivonum may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Tivonum alongside any other medications.Food Interactions
Food interactions with Tivonum are not known.Pregnancy Use
Tivonum should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Tivonum is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Tivonum is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Tivonum is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Tivonum should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Tivonum is not known.Half-Life
The half-life of Tivonum is approximately 22 days.Clearance
The clearance of Tivonum is not known.Here you find in details version of Tivonum
Some Frequently Asked Questions About Tivonum
you can give answe only.What is Tivonum?
Tivonum is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Tivonum?
The chemical name of Tivonum is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Tivonum taken?
Tivonum is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Tivonum?
The most common side effects of Tivonum include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Tivonum?
The recommended dose of Tivonum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Tivonum be used?
Tivonum should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Tivonum?
Tivonum should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Tivonum?
An overdose of Tivonum can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Tivonum is a medical emergency and should be treated as such.
What are the interactions of Tivonum with other medications?
Tivonum may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Tivonum?
The shelf life of Tivonum is three years from the date of manufacture.
Is Tivonum used for pregnant women?
The safety of Tivonum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tivonum.
Is there any generic version of Tivonum available?
No, there is not a generic version of Tivonum available.
How long does it take for Tivonum to take effect?
The effect of Tivonum is usually immediate.
How often can Tivonum be taken?
Tivonum should not be taken more than once every six hours.
What are some alternatives to Tivonum?
Alternatives to Tivonum include adenosine, aminophylline, and calcium channel blockers.
Can Tivonum be taken with other medications?
Yes, it is possible to take Tivonum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tivonum.
Can I take Tivonum if I am breastfeeding?
No, Tivonum is not recommended for women who are breastfeeding.
Is Tivonum safe for children?
No, Tivonum should not be given to children.
Can Tivonum be used for pulmonary disorders?
No, Tivonum is not recommended for the treatment of pulmonary disorders.
Does Tivonum interfere with other medications?
Yes, Tivonum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Tivonum be administered orally?
No, Tivonum should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Tivonum?
Tivonum should not be taken more than once every six hours.
What should I do if I miss a dose of Tivonum?
If you miss a dose of Tivonum, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Tivonum?
Common symptoms of an allergic reaction to Tivonum include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Tivonum with food?
Yes, it is okay to take Tivonum with food.
Can I take Tivonum if I’m on dialysis?
Tivonum should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Tivonum?
The cost of Tivonum will vary depending on the dosage and the pharmacy where it is purchased.
Is Tivonum habit-forming?
No, Tivonum is not known to be habit-forming.
Can Tivonum be used to treat arrhythmias?
Yes, Tivonum is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Tivonum?
The most common side effects of Tivonum include dizziness, nausea, and sweating.
Does Tivonum interact with other medications?
Yes, Tivonum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Tivonum a controlled substance?
No, Tivonum is not a controlled substance.
Should I take Tivonum with food?
Yes, it is okay to take Tivonum with food.
Can I take Tivonum if I’m pregnant?
No, the safety of Tivonum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tivonum.
Can Tivonum be given intramuscularly?
Yes, Tivonum can be administered intramuscularly.
How should Tivonum be stored?
Tivonum should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Tivonum?
The recommended dose of Tivonum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Tivonum cause drowsiness?
Yes, Tivonum can cause drowsiness.
Can I take Tivonum if I’m taking other medications?
Yes, it is possible to take Tivonum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tivonum.
Is Tivonum safe for the elderly?
Yes, Tivonum is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Tivonum be used to treat atrial fibrillation?
Yes, Tivonum can be used to treat atrial fibrillation.
Can Tivonum be used to treat ventricular tachycardia?
Yes, Tivonum can be used to treat ventricular tachycardia.