Visarin

Visarin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Visarin is a brand name. Its generic name is Tiemonium Methylsulphate.

Introduction

Visarin (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.

Uses

Visarin is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.

Mechanism of Action

Visarin works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.

How Long Does it Take to Work?

The effects of Visarin can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.

Absorption

Visarin is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.

Route of Elimination

Visarin is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.

Dosage

The recommended dosage of Visarin is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.

Administration

Visarin should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.

Side Effects

Common side effects of Visarin may include:
  • Redness, pain, or swelling at the injection site
  • Headache
  • Joint pain
  • Nausea
  • Diarrhea
  • Fever
  • Fatigue

Toxicity

There are no reports of toxicity associated with Visarin use, however it can cause serious side effects in certain individuals.

Precautions

  • Visarin should not be used by individuals with known hypersensitivity to the drug or any of its components.
  • Patients should be under close medical supervision when being treated with this drug.
  • Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.

Interactions

Visarin may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.

Disease Interactions

Visarin should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.

Drug Interactions

Visarin may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Visarin alongside any other medications.

Food Interactions

Food interactions with Visarin are not known.

Pregnancy Use

Visarin should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.

Lactation Use

It is not known if Visarin is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.

Acute Overdose

The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.

Contraindication

Visarin is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.

Use Direction

Visarin is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.

Storage Conditions

Visarin should be stored at 2°C to 8°C (36°F to 46°F).

Volume of Distribution

The volume of distribution of Visarin is not known.

Half-Life

The half-life of Visarin is approximately 22 days.

Clearance

The clearance of Visarin is not known.

Here you find in details version of Visarin

Some Frequently Asked Questions About Visarin

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What is Visarin?

Visarin is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.

What is the chemical name of Visarin?

The chemical name of Visarin is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.

How is Visarin taken?

Visarin is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.

What are the side Effects of Visarin?

The most common side effects of Visarin include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.

How long does Tiemonium methylsulphate last?

The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.

What is the dosage of Visarin?

The recommended dose of Visarin is 10 mg intravenously, followed by an infusion of 1 mg/minute.

When should Visarin be used?

Visarin should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.

Who should not take Visarin?

Visarin should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.

What happens if I overdose on Visarin?

An overdose of Visarin can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Visarin is a medical emergency and should be treated as such.

What are the interactions of Visarin with other medications?

Visarin may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

What is the shelf life of Visarin?

The shelf life of Visarin is three years from the date of manufacture.

Is Visarin used for pregnant women?

The safety of Visarin for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Visarin.

Is there any generic version of Visarin available?

No, there is not a generic version of Visarin available.

How long does it take for Visarin to take effect?

The effect of Visarin is usually immediate.

How often can Visarin be taken?

Visarin should not be taken more than once every six hours.

What are some alternatives to Visarin?

Alternatives to Visarin include adenosine, aminophylline, and calcium channel blockers.

Can Visarin be taken with other medications?

Yes, it is possible to take Visarin with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Visarin.

Can I take Visarin if I am breastfeeding?

No, Visarin is not recommended for women who are breastfeeding.

Is Visarin safe for children?

No, Visarin should not be given to children.

Can Visarin be used for pulmonary disorders?

No, Visarin is not recommended for the treatment of pulmonary disorders.

Does Visarin interfere with other medications?

Yes, Visarin can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

Can Visarin be administered orally?

No, Visarin should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.

How often should I take Visarin?

Visarin should not be taken more than once every six hours.

What should I do if I miss a dose of Visarin?

If you miss a dose of Visarin, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.

What are the symptoms of an allergic reaction to Visarin?

Common symptoms of an allergic reaction to Visarin include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.

Can I take Visarin with food?

Yes, it is okay to take Visarin with food.

Can I take Visarin if I’m on dialysis?

Visarin should be used with caution in patients on dialysis, as it can interact with certain medications.

What is the cost of Visarin?

The cost of Visarin will vary depending on the dosage and the pharmacy where it is purchased.

Is Visarin habit-forming?

No, Visarin is not known to be habit-forming.

Can Visarin be used to treat arrhythmias?

Yes, Visarin is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.

What are the common side effects of Visarin?

The most common side effects of Visarin include dizziness, nausea, and sweating.

Does Visarin interact with other medications?

Yes, Visarin can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

Is Visarin a controlled substance?

No, Visarin is not a controlled substance.

Should I take Visarin with food?

Yes, it is okay to take Visarin with food.

Can I take Visarin if I’m pregnant?

No, the safety of Visarin for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Visarin.

Can Visarin be given intramuscularly?

Yes, Visarin can be administered intramuscularly.

How should Visarin be stored?

Visarin should be stored at room temperature, protected from light and moisture.

What is the recommended dosage of Visarin?

The recommended dose of Visarin is 10 mg intravenously, followed by an infusion of 1 mg/minute.

Does Visarin cause drowsiness?

Yes, Visarin can cause drowsiness.

Can I take Visarin if I’m taking other medications?

Yes, it is possible to take Visarin with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Visarin.

Is Visarin safe for the elderly?

Yes, Visarin is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.

Can Visarin be used to treat atrial fibrillation?

Yes, Visarin can be used to treat atrial fibrillation.

Can Visarin be used to treat ventricular tachycardia?

Yes, Visarin can be used to treat ventricular tachycardia.