Tigecycline
Tigecycline Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tigecycline is a brand name. Its generic name is Tigecycline.
Introduction
Tigecycline is an injectable antibiotic developed for the treatment of certain bacterial infections. It was approved by the U.S. Food & Drug Administration (FDA) in 2005. Tigecycline belongs to a group of antibiotics called tetracyclines and is closely related to minocycline and doxycycline.Uses For
Tigecycline is used to treat a variety of serious infections due to susceptible bacteria including: * Nosocomial (hospital acquired) pneumonia * Complicated skin and skin structure infections * Intra-abdominal infections * Community-acquired bacterial pneumoniaMechanism of Action
Tigecycline works by inhibiting protein production in the bacteria, which helps to stop bacterial growth. Tigecycline is active against most Gram-positive and Gram-negative bacterial organisms.How Long Does it Take to Work?
Tigecycline usually takes at least 1-2 days to start working and show effects, however it may take up to 5-7 days to take full effect.Absorption
Tigecycline is administered as an intravenous infusion and is slowly absorbed into the bloodstream, reaching peak plasma concentrations in about 5 hours.Route of Elimination
Tigecycline is eliminated primarily through the kidneys and is excreted in the urine.Dosage
The recommended dose of Tigecycline is a single dose of 100 mg intravenously over not less than 60 minutes followed by a continuous infusion of 50 mg per day for 5 days.Administration
Tigecycline is administered as an intravenous infusion. It is not available in tablet form.Side Effect
Common side effects of Tigecycline include nausea, vomiting, diarrhea, stomach pain, dizziness, headache, and rash. Tell your doctor if you have any side effects that are bothersome or that do not go away.Toxicity
Tigecycline is generally well tolerated when taken as directed. Toxicities may include renal toxicity, anemia, neutropenia, and thrombocytopenia.Precautions
Tigecycline should not be used in patients with known hypersensitivity to tigecycline or any other tetracycline-class antibiotic, kidney or liver problems, or in pregnant women.Interaction
Tigecycline may interact with other medications. Tell your doctor about all other medications you are taking before starting treatment with Tigecycline.Disease Interaction
Tigecycline may not be suitable for some patients with certain pre-existing diseases. Tell your doctor if you have a history of kidney or liver disease, colitis, or myasthenia gravis before starting treatment with Tigecycline.Drug Interaction
Tigecycline may interact with other medications (especially other antibiotics, antacids, antidiarrheals, and drugs used to treat gout). Tell your doctor about all other medications you are taking before starting treatment with Tigecycline.Food Interactions
Tigecycline should be taken on an empty stomach. It is important not to take any other medications within 2 hours of taking Tigecycline.Pregnancy Use
Tigecycline should not be used during pregnancy unless absolutely necessary and only after consulting with your doctor.Lactation Use
Tigecycline should not be used while breastfeeding as it is unknown if Tigecycline is secreted in breast milk.Acute Overdose
In case of acute overdose, seek immediate medical attention.Contraindication
Tigecycline is contraindicated in patients with known hypersensitivity to tigecycline or any other tetracycline-class antibiotic, kidney or liver problems, or in pregnant women.Use Directions
It is important to follow the instructions provided by your doctor regarding dosage and frequency of administration. Tigecycline is usually administered over 60 minutes, followed by a continuous infusion.Storage Conditions
Tigecycline is typically stored at room temperature. Keep the medication in a tightly sealed container away from light and moisture.Volume of Distribution
Tigecycline has an estimated volume of distribution of 25-30 L.Half Life
Tigecycline has a half-life of approximately 18-22 hours.Clearance
Tigecycline has an estimated clearance of 1.5 L/hr/kg.Here you find in details version of Tigecycline
Some Frequently Asked Questions About Tigecycline
What is Tigecycline?
Tigecycline is an antibiotic used to treat a number of bacterial infections. It is a tetracycline derivative, and belongs to the glycylcyclines. It was developed by Wyeth Pharmaceuticals, now part of Pfizer, and is marketed under the brand names Tygacil and Tygacil.
What is Tigecycline used for?
Tigecycline is used to treat a variety of bacterial infections, including skin and abdominal infections. It is also used to treat intra-abdominal infections, such as those caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, and Pseudomonas aeruginosa.
Does Tigecycline treat all bacterial infections?
No. Tigecycline is only approved to treat a limited range of bacterial infections. If you think you may have a bacterial infection, talk to your health care provider as they may be able to recommend a different antibiotic.
Is Tigecycline safe to use?
Tigecycline is generally safe when taken as prescribed. However, like many antibiotics, it can cause certain side effects such as nausea, vomiting, diarrhea, and skin reactions. Talk to your doctor if you have any questions or concerns about taking Tigecycline.
What is the usual dosage of Tigecycline?
The usual recommended dose of Tigecycline is 50 mg intravenously every 12 hours for the initial two doses (loading dose), followed by 100 mg intravenously every 24 hours. Your physician may adjust your dosage based on your response to treatment and any adverse effects you experience.
What are the possible side effects of taking Tigecycline?
Common side effects of Tigecycline include nausea, vomiting, diarrhea, abdominal pain, and rash. Other more serious side effects may include anaphylaxis, acute renal failure, and hepatic dysfunction. Talk to your health care provider if you experience any side effects while taking Tigecycline.
Can I take Tigecycline with other medications?
It is important to tell your health care provider about all the medications you are taking before starting Tigecycline, as it may interact with certain medications, including warfarin, antacids, and other antibiotics. Your doctor may need to adjust your dose or choose a different medication.
Can I take Tigecycline while pregnant or breastfeeding?
Tigecycline should be used with caution in pregnant and nursing mothers. Talk to your doctor before starting Tigecycline if you are pregnant, planning to become pregnant, or breastfeeding.
Can I drink alcohol while taking Tigecycline?
It is recommended to avoid drinking alcohol while taking Tigecycline as it may increase the risk of serious side effects. Talk to your doctor before drinking alcohol while taking Tigecycline.
Does Tigecycline cause drowsiness?
Tigecycline may cause drowsiness. If you experience drowsiness while taking Tigecycline, it is advisable to avoid activities requiring concentration and alertness, such as driving or operating machinery.
What is the cost of Tigecycline?
The cost of Tigecycline varies depending on your insurance coverage and the pharmacy you use. It is advisable to check the cost of Tigecycline at your local pharmacy before starting treatment.
Is Tigecycline the same as other tetracyclines?
No. Tigecycline is a tetracycline derivative, but it is not the same as other tetracyclines. It has a different structure and is more stable and effective than other tetracyclines.
Can I buy Tigecycline online?
No. Tigecycline is a prescription medication, and cannot be purchased online or without a prescription. Talk to your doctor if you think Tigecycline is right for you.
What form does Tigecycline come in?
Tigecycline is available in powder form for intravenous injection. It does not come in pill form.
How long does it take for Tigecycline to work?
Tigecycline works by targeting specific bacteria in the body and killing them. It usually takes about 48-72 hours for Tigecycline to start working. Talk to your doctor if you do not notice an improvement after a few days.
When should I stop taking Tigecycline?
Tigecycline is usually prescribed for 7 to 14 days, depending on the type of infection being treated. It is important to follow your doctor’s instructions and to finish the full course of treatment, even if you feel better. Do not stop taking Tigecycline before your doctor has indicated it is okay to do so.
What should I do if I forget to take a dose of Tigecycline?
If you forget to take a dose of Tigecycline, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose of Tigecycline.
Does Tigecycline expire?
Yes, Tigecycline has an expiry date. Discard any unused Tigecycline powder after the expiry date.
How should I store Tigecycline?
Tigecycline powder should be stored at room temperature between 15-30°C (59-86°F). Keep it in the original container, and out of reach of children.
Does Tigecycline interact with other medications?
Tigecycline can interact with certain medications, including warfarin, antacids, and other antibiotics. Talk to your doctor before taking any other medications while you are taking Tigecycline.
Does Tigecycline treat anthrax?
No, Tigecycline is not approved for the treatment of anthrax. If you think you may have anthrax, talk to your health care provider and they may be able to recommend a different antibiotic.
Can Tigecycline be used to treat gonorrhea?
No, Tigecycline is not approved for the treatment of gonorrhea. If you think you may have gonorrhea, talk to your health care provider and they may be able to recommend a different antibiotic.
What foods should I avoid while taking Tigecycline?
You should avoid dairy products and calcium-containing foods or supplements while taking Tigecycline, as they may interfere with the absorption of the medication. Talk to your doctor about other foods and supplements to avoid while taking Tigecycline.
Does Tigecycline cause photosensitivity?
Yes, Tigecycline can cause photosensitivity, which is an increased sensitivity to light. To reduce your risk of photosensitivity, it is advisable to wear sunscreen and protective clothing while taking Tigecycline.
Can I take acetaminophen while taking Tigecycline?
It is not recommended to take acetaminophen while taking Tigecycline. Acetaminophen can increase the risk of liver damage if taken with Tigecycline. Talk to your doctor if you need to take acetaminophen while taking Tigecycline.
Is Tigecycline safe for children?
Tigecycline is not recommended for use in children under 18 years of age. Talk to your doctor for alternative antibiotics that may be more suitable for children.
What are the symptoms of an allergic reaction to Tigecycline?
The symptoms of an allergic reaction to Tigecycline include itching, hives, swelling, difficulty breathing, and rash. If you experience any of these symptoms, seek immediate emergency medical help.
Can Tigecycline be used to treat urinary tract infections?
No, Tigecycline is not approved for the treatment of urinary tract infections. If you think you may have a urinary tract infection, talk to your health care provider and they may be able to recommend a different antibiotic.
Does Tigecycline cause liver damage?
Tigecycline can cause liver damage, especially if taken with alcohol or acetaminophen. Talk to your doctor if you experience any signs of liver damage such as abdominal pain, nausea, or yellowing of the skin or eyes.
What should I do if I experience an adverse reaction while taking Tigecycline?
If you experience any adverse reactions while taking Tigecycline, such as rash, nausea, vomiting, or abdominal pain, talk to your doctor. Your doctor may adjust your dose or switch you to another antibiotic.
Can I take other medications while taking Tigecycline?
It is important to tell your doctor about all the medications you are taking before starting Tigecycline. Some medications, such as warfarin, antacids, and other antibiotics, may interact with Tigecycline. Your doctor may need to adjust your dose or choose a different medication.
Is Tigecycline available over-the-counter?
No, Tigecycline is a prescription medication, and cannot be purchased over-the-counter or without a prescription.
How long does it take for Tigecycline to be effective?
It usually takes 48-72 hours for Tigecycline to start working. Talk to your doctor if you do not notice an improvement after a few days.
Does Tigecycline have any drug interactions?
Tigecycline can interact with certain medications, including warfarin, antacids, and other antibiotics. It is important to tell your doctor about all the medications you are taking before starting Tigecycline.
Will my insurance cover the cost of Tigecycline?
Some insurance plans may cover the cost of Tigecycline. It is best to check with your insurance provider to see if Tigecycline is covered by your plan.
Can I take Tigecycline with food?
It is recommended to take Tigecycline with food to reduce the risk of stomach upset. Talk to your doctor if you have any questions.
What should I do if I miss a dose of Tigecycline?
If you miss a dose of Tigecycline, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose of Tigecycline.
Can I take probiotics while taking Tigecycline?
It is not recommended to take probiotics while taking Tigecycline, as probiotics may interact with the medication. Talk to your doctor if you need to take probiotics while taking Tigecycline.
Can I go in the sun while taking Tigecycline?
It is advisable to avoid prolonged exposure to the sun while taking Tigecycline, as it can cause photosensitivity. To reduce your risk of photosensitivity, it is advisable to wear sunscreen and protective clothing while taking Tigecycline.
Does Tigecycline cause kidney damage?
Tigecycline can cause kidney damage, especially in people with kidney disease. If you