Tigeciclina
Tigeciclina Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tigeciclina is a brand name. Its generic name is Tigecycline.
Introduction
Tigeciclina is an injectable antibiotic developed for the treatment of certain bacterial infections. It was approved by the U.S. Food & Drug Administration (FDA) in 2005. Tigeciclina belongs to a group of antibiotics called tetracyclines and is closely related to minocycline and doxycycline.Uses For
Tigeciclina is used to treat a variety of serious infections due to susceptible bacteria including: * Nosocomial (hospital acquired) pneumonia * Complicated skin and skin structure infections * Intra-abdominal infections * Community-acquired bacterial pneumoniaMechanism of Action
Tigeciclina works by inhibiting protein production in the bacteria, which helps to stop bacterial growth. Tigeciclina is active against most Gram-positive and Gram-negative bacterial organisms.How Long Does it Take to Work?
Tigeciclina usually takes at least 1-2 days to start working and show effects, however it may take up to 5-7 days to take full effect.Absorption
Tigeciclina is administered as an intravenous infusion and is slowly absorbed into the bloodstream, reaching peak plasma concentrations in about 5 hours.Route of Elimination
Tigeciclina is eliminated primarily through the kidneys and is excreted in the urine.Dosage
The recommended dose of Tigeciclina is a single dose of 100 mg intravenously over not less than 60 minutes followed by a continuous infusion of 50 mg per day for 5 days.Administration
Tigeciclina is administered as an intravenous infusion. It is not available in tablet form.Side Effect
Common side effects of Tigeciclina include nausea, vomiting, diarrhea, stomach pain, dizziness, headache, and rash. Tell your doctor if you have any side effects that are bothersome or that do not go away.Toxicity
Tigeciclina is generally well tolerated when taken as directed. Toxicities may include renal toxicity, anemia, neutropenia, and thrombocytopenia.Precautions
Tigeciclina should not be used in patients with known hypersensitivity to tigecycline or any other tetracycline-class antibiotic, kidney or liver problems, or in pregnant women.Interaction
Tigeciclina may interact with other medications. Tell your doctor about all other medications you are taking before starting treatment with Tigeciclina.Disease Interaction
Tigeciclina may not be suitable for some patients with certain pre-existing diseases. Tell your doctor if you have a history of kidney or liver disease, colitis, or myasthenia gravis before starting treatment with Tigeciclina.Drug Interaction
Tigeciclina may interact with other medications (especially other antibiotics, antacids, antidiarrheals, and drugs used to treat gout). Tell your doctor about all other medications you are taking before starting treatment with Tigeciclina.Food Interactions
Tigeciclina should be taken on an empty stomach. It is important not to take any other medications within 2 hours of taking Tigeciclina.Pregnancy Use
Tigeciclina should not be used during pregnancy unless absolutely necessary and only after consulting with your doctor.Lactation Use
Tigeciclina should not be used while breastfeeding as it is unknown if Tigeciclina is secreted in breast milk.Acute Overdose
In case of acute overdose, seek immediate medical attention.Contraindication
Tigeciclina is contraindicated in patients with known hypersensitivity to tigecycline or any other tetracycline-class antibiotic, kidney or liver problems, or in pregnant women.Use Directions
It is important to follow the instructions provided by your doctor regarding dosage and frequency of administration. Tigeciclina is usually administered over 60 minutes, followed by a continuous infusion.Storage Conditions
Tigeciclina is typically stored at room temperature. Keep the medication in a tightly sealed container away from light and moisture.Volume of Distribution
Tigeciclina has an estimated volume of distribution of 25-30 L.Half Life
Tigeciclina has a half-life of approximately 18-22 hours.Clearance
Tigeciclina has an estimated clearance of 1.5 L/hr/kg.Here you find in details version of Tigeciclina
Some Frequently Asked Questions About Tigeciclina
What is Tigeciclina?
Tigeciclina is an antibiotic used to treat a number of bacterial infections. It is a tetracycline derivative, and belongs to the glycylcyclines. It was developed by Wyeth Pharmaceuticals, now part of Pfizer, and is marketed under the brand names Tygacil and Tygacil.
What is Tigeciclina used for?
Tigeciclina is used to treat a variety of bacterial infections, including skin and abdominal infections. It is also used to treat intra-abdominal infections, such as those caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, and Pseudomonas aeruginosa.
Does Tigeciclina treat all bacterial infections?
No. Tigeciclina is only approved to treat a limited range of bacterial infections. If you think you may have a bacterial infection, talk to your health care provider as they may be able to recommend a different antibiotic.
Is Tigeciclina safe to use?
Tigeciclina is generally safe when taken as prescribed. However, like many antibiotics, it can cause certain side effects such as nausea, vomiting, diarrhea, and skin reactions. Talk to your doctor if you have any questions or concerns about taking Tigeciclina.
What is the usual dosage of Tigeciclina?
The usual recommended dose of Tigeciclina is 50 mg intravenously every 12 hours for the initial two doses (loading dose), followed by 100 mg intravenously every 24 hours. Your physician may adjust your dosage based on your response to treatment and any adverse effects you experience.
What are the possible side effects of taking Tigeciclina?
Common side effects of Tigeciclina include nausea, vomiting, diarrhea, abdominal pain, and rash. Other more serious side effects may include anaphylaxis, acute renal failure, and hepatic dysfunction. Talk to your health care provider if you experience any side effects while taking Tigeciclina.
Can I take Tigeciclina with other medications?
It is important to tell your health care provider about all the medications you are taking before starting Tigeciclina, as it may interact with certain medications, including warfarin, antacids, and other antibiotics. Your doctor may need to adjust your dose or choose a different medication.
Can I take Tigeciclina while pregnant or breastfeeding?
Tigeciclina should be used with caution in pregnant and nursing mothers. Talk to your doctor before starting Tigeciclina if you are pregnant, planning to become pregnant, or breastfeeding.
Can I drink alcohol while taking Tigeciclina?
It is recommended to avoid drinking alcohol while taking Tigeciclina as it may increase the risk of serious side effects. Talk to your doctor before drinking alcohol while taking Tigeciclina.
Does Tigeciclina cause drowsiness?
Tigeciclina may cause drowsiness. If you experience drowsiness while taking Tigeciclina, it is advisable to avoid activities requiring concentration and alertness, such as driving or operating machinery.
What is the cost of Tigeciclina?
The cost of Tigeciclina varies depending on your insurance coverage and the pharmacy you use. It is advisable to check the cost of Tigeciclina at your local pharmacy before starting treatment.
Is Tigeciclina the same as other tetracyclines?
No. Tigeciclina is a tetracycline derivative, but it is not the same as other tetracyclines. It has a different structure and is more stable and effective than other tetracyclines.
Can I buy Tigeciclina online?
No. Tigeciclina is a prescription medication, and cannot be purchased online or without a prescription. Talk to your doctor if you think Tigeciclina is right for you.
What form does Tigeciclina come in?
Tigeciclina is available in powder form for intravenous injection. It does not come in pill form.
How long does it take for Tigeciclina to work?
Tigeciclina works by targeting specific bacteria in the body and killing them. It usually takes about 48-72 hours for Tigeciclina to start working. Talk to your doctor if you do not notice an improvement after a few days.
When should I stop taking Tigeciclina?
Tigeciclina is usually prescribed for 7 to 14 days, depending on the type of infection being treated. It is important to follow your doctor’s instructions and to finish the full course of treatment, even if you feel better. Do not stop taking Tigeciclina before your doctor has indicated it is okay to do so.
What should I do if I forget to take a dose of Tigeciclina?
If you forget to take a dose of Tigeciclina, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose of Tigeciclina.
Does Tigeciclina expire?
Yes, Tigeciclina has an expiry date. Discard any unused Tigeciclina powder after the expiry date.
How should I store Tigeciclina?
Tigeciclina powder should be stored at room temperature between 15-30°C (59-86°F). Keep it in the original container, and out of reach of children.
Does Tigeciclina interact with other medications?
Tigeciclina can interact with certain medications, including warfarin, antacids, and other antibiotics. Talk to your doctor before taking any other medications while you are taking Tigeciclina.
Does Tigeciclina treat anthrax?
No, Tigeciclina is not approved for the treatment of anthrax. If you think you may have anthrax, talk to your health care provider and they may be able to recommend a different antibiotic.
Can Tigeciclina be used to treat gonorrhea?
No, Tigeciclina is not approved for the treatment of gonorrhea. If you think you may have gonorrhea, talk to your health care provider and they may be able to recommend a different antibiotic.
What foods should I avoid while taking Tigeciclina?
You should avoid dairy products and calcium-containing foods or supplements while taking Tigeciclina, as they may interfere with the absorption of the medication. Talk to your doctor about other foods and supplements to avoid while taking Tigeciclina.
Does Tigeciclina cause photosensitivity?
Yes, Tigeciclina can cause photosensitivity, which is an increased sensitivity to light. To reduce your risk of photosensitivity, it is advisable to wear sunscreen and protective clothing while taking Tigeciclina.
Can I take acetaminophen while taking Tigeciclina?
It is not recommended to take acetaminophen while taking Tigeciclina. Acetaminophen can increase the risk of liver damage if taken with Tigeciclina. Talk to your doctor if you need to take acetaminophen while taking Tigeciclina.
Is Tigeciclina safe for children?
Tigeciclina is not recommended for use in children under 18 years of age. Talk to your doctor for alternative antibiotics that may be more suitable for children.
What are the symptoms of an allergic reaction to Tigeciclina?
The symptoms of an allergic reaction to Tigeciclina include itching, hives, swelling, difficulty breathing, and rash. If you experience any of these symptoms, seek immediate emergency medical help.
Can Tigeciclina be used to treat urinary tract infections?
No, Tigeciclina is not approved for the treatment of urinary tract infections. If you think you may have a urinary tract infection, talk to your health care provider and they may be able to recommend a different antibiotic.
Does Tigeciclina cause liver damage?
Tigeciclina can cause liver damage, especially if taken with alcohol or acetaminophen. Talk to your doctor if you experience any signs of liver damage such as abdominal pain, nausea, or yellowing of the skin or eyes.
What should I do if I experience an adverse reaction while taking Tigeciclina?
If you experience any adverse reactions while taking Tigeciclina, such as rash, nausea, vomiting, or abdominal pain, talk to your doctor. Your doctor may adjust your dose or switch you to another antibiotic.
Can I take other medications while taking Tigeciclina?
It is important to tell your doctor about all the medications you are taking before starting Tigeciclina. Some medications, such as warfarin, antacids, and other antibiotics, may interact with Tigeciclina. Your doctor may need to adjust your dose or choose a different medication.
Is Tigeciclina available over-the-counter?
No, Tigeciclina is a prescription medication, and cannot be purchased over-the-counter or without a prescription.
How long does it take for Tigeciclina to be effective?
It usually takes 48-72 hours for Tigeciclina to start working. Talk to your doctor if you do not notice an improvement after a few days.
Does Tigeciclina have any drug interactions?
Tigeciclina can interact with certain medications, including warfarin, antacids, and other antibiotics. It is important to tell your doctor about all the medications you are taking before starting Tigeciclina.
Will my insurance cover the cost of Tigeciclina?
Some insurance plans may cover the cost of Tigeciclina. It is best to check with your insurance provider to see if Tigeciclina is covered by your plan.
Can I take Tigeciclina with food?
It is recommended to take Tigeciclina with food to reduce the risk of stomach upset. Talk to your doctor if you have any questions.
What should I do if I miss a dose of Tigeciclina?
If you miss a dose of Tigeciclina, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose of Tigeciclina.
Can I take probiotics while taking Tigeciclina?
It is not recommended to take probiotics while taking Tigeciclina, as probiotics may interact with the medication. Talk to your doctor if you need to take probiotics while taking Tigeciclina.
Can I go in the sun while taking Tigeciclina?
It is advisable to avoid prolonged exposure to the sun while taking Tigeciclina, as it can cause photosensitivity. To reduce your risk of photosensitivity, it is advisable to wear sunscreen and protective clothing while taking Tigeciclina.
Does Tigeciclina cause kidney damage?
Tigeciclina can cause kidney damage, especially in people with kidney disease. If you