Tianeptine

Tianeptine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tianeptine is a brand name. Its generic name is Tianeptine.

Tianeptine Introduction

Tianeptine is a medication used to treat depression and other mood disorders. It works by impacting the neural pathways of the brain related to mood and anxiety. It is believed to increase serotonin availability at the neuronal level, which helps regulate a person’s mood. Tianeptine is available as tablets, intramuscular injections, and rectal suppositories.

Uses For

Tianeptine is indicated for the treatment of major depressive disorder (MDD) and anxiety disorder in adults. It can also be used to treat eating disorders, alcoholism, and post-traumatic stress disorder (PTSD).

Mechanism of Action

Tianeptine works by increasing the levels of serotonin in the brain. Serotonin is one of the primary hormones responsible for maintaining a person’s mood and regulating their emotions. It can also help improve cognitive function, memory, and concentration. By increasing the availability of serotonin, tianeptine can help to alleviate the symptoms of depression and anxiety and make it easier to control cravings for alcohol or food.

How Long Does it Take to Work?

Tianeptine typically takes between 4-6 weeks to take effect. In some cases, it may take longer for the full effects to be felt. It is important to follow the prescribed dosage and not to change it without consulting a doctor.

Absorption

Tianeptine is absorbed quickly when taken orally. On an empty stomach, it is absorbed within 30 minutes and the maximum concentration in the bloodstream is typically reached in 2-3 hours.

Route of Elimination

Tianeptine is metabolized in the liver and eliminated via the kidneys in urine. The elimination half-life of tianeptine is 4-6 hours.

Dosage

The recommended starting dose of tianeptine is 12.5 mg taken orally three times daily. This can be increased by the doctor to a maximum dose of 50 mg taken orally four times daily. Different patients will respond differently to the drug, and the dosage may need to be adjusted accordingly.

Administration

Tianeptine should be taken orally, ideally with food. It is also recommended not to take the medication for more than 12 weeks at a time. Long-term use of tianeptine has not been studied and may be associated with an increased risk of side effects.

Side Effects

Common side effects associated with tianeptine include nausea, headache, abdominal pain, dry mouth, dizziness, and drowsiness. More serious side effects may include muscle pain or weakness, irregular heartbeat, increased sweating, or seizures.

Toxicity

Overdosing on tianeptine can lead to severe acute toxicity. Symptoms of tianeptine toxicity include tremors, confusion, agitation, disorientation, tachycardia, and hyperthermia.

Precaution

Tianeptine should not be taken by people with known or suspected hypersensitivity to the drug, women who are pregnant or breastfeeding, as well as people who are taking medicines for the treatment of psychiatric diseases.

Interaction

Tianeptine can interact with certain drugs, such as anti-anxiety medicines, antibiotics, antipsychotics, anticonvulsants, and medications for HIV. It can also interact with foods such as cheese and wine and with supplements such as St. John’s wort.

Disease Interaction

Tianeptine can be used in some cases to treat conditions such as epilepsy, Parkinson’s disease, and ADHD. However, it is not recommended for use in people with liver disease, kidney disease, or seizure disorders.

Drug Interaction

Tianeptine can interact with other drugs, such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SSRIs/SNRIs), antiarrhythmic agents, antipsychotics, and benzodiazepines.

Food Interactions

Tianeptine interacts with certain foods such as cheese and wine. It can also interact with certain supplements such as St. John's Wort.

Pregnancy Use

Tianeptine is not recommended for pregnant women due to its potential to cause serious birth defects.

Lactation Use

Tianeptine is not recommended for breastfeeding mothers since it can be passed through breast milk.

Acute Overdose

An acute overdose of tianeptine can lead to serious symptoms including confusion, agitation, disorientation, tachycardia, and hyperthermia. In the event of an overdose, emergency medical attention should be sought immediately.

Contraindication

Tianeptine should not be used in people who are allergic to it, pregnant women, breastfeeding mothers, or people with liver, kidney, or seizure disorders.

Use Direction

Tianeptine should be taken orally as prescribed by a doctor. It should be taken with food and never taken for longer than 12 weeks at a time. It is important to follow the dosage instructions closely or the effectiveness of the medication may be reduced.

Storage Condition

Tianeptine should be stored at room temperature away from heat, light, and moisture. It should be kept out of the reach of children.

Volume of Distribution

The volume of distribution for tianeptine is 5.4 L/kg.

Half Life

The elimination half-life of tianeptine is 4-6 hours.

Clearance

The clearance rate of tianeptine is 57.3 L/hour.

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Some Frequently Asked Questions About Tianeptine

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What is Tianeptine?

Tianeptine is an antidepressant drug commonly used to treat depression, anxiety, and mood disorders. It works by increasing the levels of two chemicals in the brain: serotonin and dopamine. It also causes changes in the brain which make it more resistant to stress.

How does Tianeptine work?

Tianeptine works by increasing serotonin and dopamine levels in the brain. It also produces changes in the brain which make it more resilient to stress. This contributes to its effectiveness as an antidepressant.

Is Tianeptine an SSRI?

No. Tianeptine is not an SSRI (selective serotonin reuptake inhibitor). It is classified as a non-SSRI antidepressant and works differently than SSRIs.

What are the side effects of Tianeptine?

Common side effects of Tianeptine include stomach upset, nausea, and dizziness. Other possible side effects include headaches, dry mouth, blurred vision, and drowsiness. It is important to speak to your doctor if you experience any bothersome side effects or if they become severe.

Is Tianeptine used to treat anxiety?

Yes. Tianeptine is commonly used to treat anxiety as well as depression and mood disorders.

What is the dosage of Tianeptine?

The dosage of Tianeptine varies depending on the type of medication you are taking. Oral tianeptine usually comes in 12.5mg, 25mg or 50mg tablets or capsules. available as sustained-release tablets called Stablon. It is important to take tianeptine exactly as your doctor has prescribed.

Does Tianeptine help with sleep?

Yes. Tianeptine can help improve sleep quality in people with depression. It also seems to increase total sleep time compared to placebo.

How long does it take for Tianeptine to work?

Most people experience significant improvements in mood within two to four weeks of starting tianeptine. However, it can take longer depending on the individual and severity of their condition.

Is Tianeptine a controlled substance?

Yes. Tianeptine is classified as a controlled substance in many countries including the United States. It is illegal to buy, sell, or possess tianeptine without a prescription from a doctor.

Is Tianeptine addictive?

Tianeptine does have the potential for abuse and dependence, especially when taken in high doses for an extended period of time. It is important to follow the instructions of your doctor and take the medication exactly as prescribed.

Can Tianeptine cause weight gain?

It is possible that tianeptine could cause weight gain, although research is limited. Some people have reported weight gain when taking tianeptine, so it may be worth discussing with your doctor if this is a concern.

Does Tianeptine have any interactions with other drugs?

Yes. Tianeptine can interact with other drugs and medications, including antidepressants, mood stabilizers, and antipsychotics. It is important to discuss any other medications you are taking with your doctor before starting tianeptine.

What happens if I miss a dose of Tianeptine?

It is important to take tianeptine exactly as prescribed by your doctor. If you miss a dose, take it as soon as you remember. If it is nearing the time of your next dose, skip the missed dose and take the next one as directed. Do not double dose.

What is the difference between Tianeptine and SSRIs?

Tianeptine is a non-SSRI antidepressant, which means that it works differently than SSRIs (selective serotonin reuptake inhibitors). SSRIs primarily work by increasing serotonin, whereas tianeptine increases both serotonin and dopamine levels. Both medications are used to treat depression, but it is important to discuss which one is right for you with your doctor.

Can I drink alcohol while taking Tianeptine?

It is not recommended to drink alcohol while taking tianeptine. Alcohol can worsen the side effects of tianeptine and can also interfere with its effectiveness. If you do choose to drink, it is important to do so in moderation.

Is it safe to take Tianeptine long-term?

Tianeptine is generally safe to take long-term, but it is important to discuss the risks and benefits with your doctor before doing so. Long-term use of tianeptine can lead to tolerance, addiction, and withdrawal symptoms.

Can children and teenagers take Tianeptine?

Tianeptine is not recommended for use in children or teenagers, due to a lack of research on its safety and efficacy in this age group. Speak to your doctor if you are considering tianeptine for anyone under 18.

Does Tianeptine cause liver damage?

Tianeptine may cause liver damage in rare cases. It is important to talk to your doctor if you experience any unusual changes in your liver function tests.

Can I take Tianeptine while breastfeeding?

Tianeptine is not recommended for use while breastfeeding due to a lack of research on its safety and efficacy. It is important to speak to your doctor if you are considering taking tianeptine while breastfeeding.

Does Tianeptine have anti-anxiety properties?

Yes. Tianeptine is commonly used to treat anxiety, depression, and mood disorders. It may also help to reduce the symptoms of anxiety.

Can Tianeptine cause hair loss?

It is possible that tianeptine could cause hair loss in rare cases. Speak to your doctor if you experience any unusual changes in your hair or scalp.

Does Tianeptine cause constipation?

It is possible that tianeptine could cause constipation, although this is not a common side effect. If you experience constipation while taking tianeptine, it is important to speak to your doctor.

Does Tianeptine cause dry mouth?

Yes. Dry mouth is a common side effect of tianeptine, although it usually does not last long. If you experience dry mouth, it is important to drink plenty of fluids, chew sugar-free gum, or use a saliva substitute to help keep your mouth moist.

Does Tianeptine have anti-inflammatory properties?

Yes. Tianeptine has been found to have anti-inflammatory properties that may be beneficial for conditions such as arthritis. However, more research is needed to confirm these effects.

Can I take Tianeptine with other medications?

It is important to always discuss any other medications you are taking with your doctor before taking tianeptine. Certain medications may interact with tianeptine, so it is important to be cautious when taking any other drugs or supplements.

Is Tianeptine safe for pregnant women?

Tianeptine is not recommended for use in pregnant women, as its safety has not been established. Speak to your doctor if you are considering taking tianeptine while pregnant.

Can I take Tianeptine and Xanax together?

It is not recommended to take tianeptine and Xanax (alprazolam) together as they both work on the same neurotransmitters in the brain. It is important to speak to your doctor before taking any two medications together.

Does Tianeptine cause blurred vision?

Yes. Blurred vision is a possible side effect of tianeptine, although it is not common. Speak to your doctor if you experience blurred vision while taking tianeptine.

Can Tianeptine help with chronic pain?

Tianeptine has been researched as a possible treatment for chronic pain. Some studies have suggested that tianeptine may reduce pain intensity in people with chronic pain. However, more research is needed to confirm these results.

What is the best time of day to take Tianeptine?

Tianeptine is usually taken once or twice daily, depending on the type of medication you are taking. It is best to take it at the same time each day for consistent results. Speak to your doctor for more specific instructions on when to take your medication.

Can I take Tianeptine with food?

Yes. It is generally recommended to take tianeptine with food or after meals to reduce the chances of stomach upset.

Does Tianeptine cause drowsiness?

Yes. Drowsiness is a possible side effect of tianeptine, although it is not common. If you experience drowsiness while taking tianeptine, it is important to speak to your doctor.

Is Tianeptine available in the United States?

Tianeptine is not approved by the FDA for use in the United States, so it is not available by prescription. It is available, however, as an over-the-counter supplement, although its safety and efficacy have not been established.

What is the recommended dosage of Tianeptine?

The recommended dosage of tianeptine varies depending on the type of medication you are taking. Oral tianeptine usually comes in 12.5mg, 25mg or 50mg tablets or capsules. It is important to take tianeptine exactly as prescribed by your doctor.

Is Tianeptine legal in the United States?

Tianeptine is not approved by the FDA for use in the United States, so it is illegal to buy, sell, or possess without a prescription from a doctor.

Does Tianeptine help with depression?

Yes. Tianeptine is commonly used to treat depression, anxiety, and mood disorders. It works by increasing serotonin and dopamine levels in the brain, which can help to reduce symptoms of depression.

Is Tianeptine safe for elderly people?

Tianeptine has not been adequately studied in elderly people, so its safety and efficacy in this age group is unknown. Speak to your doctor if you are considering taking tianeptine as an elderly person.

Can Tianeptine cause suicidal thoughts?

Tianeptine is generally considered safe to take, and it is not known to cause suicidal thoughts or behavior. However, it is important to be aware that all antidepressants, including tianeptine, can cause this as a side effect. Speak to your doctor if you experience any worrying thoughts or behavior while taking tianeptine.

Can Tianeptine treat post-traumatic stress disorder?

Tianeptine has been studied as a possible treatment for post-traumatic stress disorder (PTSD). Early studies suggest that tianeptine may help to reduce the symptoms of PTSD, but more research is needed before any definitive conclusions can be made.