Tafecta
Tafecta Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tafecta is a brand name. Its generic name is Tenofovir Alafenamide.
Tafecta
Tafecta (TAF) is an antiviral medication used in the treatment of HIV-1 infection. It is a prodrug of tenofovir, and works by interfering with the ability of the virus to copy itself. As a result, it can decrease the amount of HIV in the body. TAF has been approved for use in combination with other antiretroviral agents in patients with HIV-1.
Uses for Tafecta
TDF is used in combination with other anti-HIV drugs to treat HIV-1 infection in adults over 18 years of age. It is not recommended for use in patients under 18 years of age.
Mechanism of Action
By inhibiting the enzyme reverse transcriptase, tenofovir alafenamide interferes with HIV's ability to replicate itself. This action reduces the amount of virus in the body, allowing the immune system to fight off infection.
How Long Does It Take to Work?
TDF can start working within a few days of taking the drug. However, it can take several weeks for the drug to reach its full effect. Most people will see improvement in their HIV symptoms within a few weeks of starting treatment.
Absorption
TAF is rapidly and complete absorbed in the small intestine when taken by mouth.
Route of Elimination
TAF is primarily eliminated through the kidneys. The majority of the drug is eliminated unchanged in the urine.
Dosage
TAF is usually taken once-daily with or without food. The recommended dose is 300 mg taken by mouth.
Administration
TAF is usually taken once-daily with or without food. The recommended dose is 300 mg taken by mouth.
Side Effect
Common side effects of TAF include headaches, nausea, abdominal pain, and diarrhea. Less common side effects include rash, itching, vomiting, and dizziness.
Toxicity
In animal studies, TAF has shown to be safe at doses up to 30 times higher than the recommended dose for humans. The most commonly seen side effects in humans are headache, nausea, and abdominal pain. At high doses (up to 900 mg daily), TAF has been associated with kidney toxicity, though this is rare in humans.
Precaution
TAF should be used with caution in patients with kidney impairment, as it may cause further kidney damage. Patients with liver dysfunction should also be monitored carefully, as TAF may increase the risk of liver damage. It should not be used in pregnant women due to the risk of harm to the fetus.
Interaction
TAF can interact with other medications, such as antacids, anticonvulsants, and corticosteroids. It should not be taken with other drugs that can cause kidney toxicity.
Disease Interaction
TAF works by interfering with the ability of the virus to copy itself, which can decrease the amount of HIV in the body. As a result, TAF can potentially interact with other diseases, and should be used with caution in patients with kidney or liver impairment.
Drug Interaction
TAF can potentially interact with other drugs, such as antacids, anticonvulsants, corticosteroids, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, and antibiotics. Patients taking these drugs should be monitored carefully for potential interactions.
Food Interactions
TAF should not be taken with food. Taking it with food can significantly reduce the amount of drug that is absorbed by the body.
Pregnancy Use
TAF is not recommended for use in pregnant women, as it may cause harm to the unborn child. Women who are pregnant should discuss other treatment options with their doctor.
Lactation Use
It is not known if TAF is excreted in breast milk. Women taking TAF should avoid breast-feeding, as it may cause harm to the baby.
Acute Overdose
Symptoms of an overdose include nausea, vomiting, dizziness, and abdominal pain. If an overdose is suspected, medical attention should be sought immediately.
Contraindication
TAF should not be used in patients with severe kidney impairment. It should also be used with caution in patients with liver dysfunction. Pregnant women should not take TAF, as it may cause harm to the fetus.
Use Direction
TAF should be taken as directed by your doctor. The recommended dose is 300 mg taken once-daily either with or without food.
Storage Condition
TAF should be stored at room temperature, away from light and moisture. Keep out of reach of children.
Volume of Distribution
TAF has a volume of distribution of approximately 3.3 L/kg.
Half Life
TAF has a half life of approximately 14 hours.
Clearance
TAF has a clearance of approximately 1.2 L/h/kg.
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