Shiltrone

Shiltrone Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Shiltrone is a brand name. Its generic name is Granisetron.

Shiltrone

Shiltrone is an antiemetic prescription medication used to prevent nausea and vomiting caused by cancer treatments, such as chemotherapy and radiation therapy. It is available in oral and injectable formulations.

Uses

Shiltrone is commonly used for the prevention of nausea and vomiting in patients receiving chemotherapy or radiation therapy. It can also be used to prevent and treat postoperative nausea and vomiting.

Mechanism of Action

Shiltrone works by blocking the action of the hormone serotonin on the cells in the stomach and intestine, which helps to reduce nausea and vomiting. Serotonin is a natural occurring substance in the body that is associated with the stimulation of vomiting.

How Long Does it Take to Work?

Shiltrone takes approximately 30 minutes to begin working. The effects of the medication can last up to 24 hours.

Absorption

Shiltrone is highly soluble in water and is quickly and completely absorbed after oral administration.

Route of Elimination

Shiltrone is mainly metabolized in the liver and then excreted by the kidneys.

Dosage

Shiltrone is available as an oral solution, injection, and suppository. The dosage will depend on the condition being treated, the type of formulation, the patient's age, and any other medical conditions. General adult dosing for the oral solution is 2 mg twice a day, while for the injection it is 1 mg once a day. For the suppository, the dose is 2 mg once a day at least 30 minutes prior to harvesting.

Administration

For oral administration, Shiltrone should be taken with food or milk. Shiltrone injections may be given intravenously or intramuscularly. The suppository should be inserted high into the rectum and no additional lubrication should be used. Do not use hot water.

Side Effects

Side effects with Shiltrone can include headache, constipation, dizziness, fatigue, and dry mouth. More serious side effects may include difficulty breathing, fast heartbeat, fainting, or seizures.

Toxicity

Shiltrone is generally well tolerated with few serious side effects. Overdose of Shiltrone can cause severe drowsiness and difficulty breathing. Call 911 or go to the nearest emergency room if you have taken an overdose of Shiltrone.

Precaution

Shiltrone should not be taken by people who are hypersensitive to the medication or who have severe kidney or liver disease.

Interactions

Shiltrone may interact with other medications, including cancer treatments, antibiotics, antifungals, and blood thinners. Be sure to tell your doctor about all medications and supplements you are taking before starting Shiltrone.

Disease Interaction

Shiltrone can interact with certain medical conditions, such as kidney or liver disease, a history of seizures, or a personal or family history of long QT syndrome. Be sure to tell your doctor about any medical condition that you have before taking Shiltrone.

Drug Interactions

Shiltrone can interact with certain medications, such as cancer treatments, antibiotics, antifungal agents, and blood thinners. Be sure to tell your doctor about all medications and supplements you are taking before starting Shiltrone.

Food Interactions

Shiltrone should be taken with food or milk to help reduce acid reflux. Grapefruit or grapefruit juice should be avoided while taking this medication as it may interact with Shiltrone.

Pregnancy Use

Shiltrone is considered OB category B, meaning it is not expected to be harmful to an unborn baby. However, Shiltrone should therefore be avoided in pregnancy unless clearly needed.

Lactation Use

Shiltrone should not be used during breastfeeding because the drug could pass into breastmilk and harm the infant.

Acute Overdose

If an overdose of Shiltrone is suspected, contact a poison control center immediately or seek medical attention. An overdose of Shiltrone can cause drowsiness, difficulty breathing, and loss of consciousness.

Contraindication

Shiltrone should not be used in patients who are allergic to the medication or have severe kidney or liver disease.

Use Direction

Always follow your doctor's instructions when taking Shiltrone. Do not exceed the recommended dose of the medication or take it for a longer period of time than prescribed.

Storage Condition

Store Shiltrone at room temperature and avoid exposing it to moisture and direct sunlight.

Volume of Distribution

Shiltrone has a volume of distribution of 1.2 L/kg.

Half Life

Shiltrone has an elimination half-life of 8.8 hours.

Clearance

Shiltrone has a clearance mehtod of 1.7 mL/min/kg.

Here you find in details version of Shiltrone

Some Frequently Asked Questions About Shiltrone

What is Shiltrone?

Shiltrone is a medication that is used to prevent nausea and vomiting caused by chemotherapy treatments and radiation therapy. It is a selective serotonin 5-HT3 receptor antagonist, which acts on certain receptors in the brain to reduce the nausea and vomiting associated with cancer treatments.

How does Shiltrone work?

Shiltrone works by blocking serotonin receptors in the brain, thus reducing the symptoms of nausea and vomiting caused by chemotherapy and radiation therapy. This helps to reduce the uncomfortable side effects associated with these treatments.

What are the side effects of Shiltrone?

The most common side effects of Shiltrone are headache, constipation, diarrhea, fatigue, and dizziness. However, more serious side effects include severe anemia, pancreatitis, low blood pressure, and seizures.

When should Shiltrone be used?

Shiltrone should be used when nausea and vomiting from chemotherapy or radiation become too severe or when other medications are not providing relief. It is best to talk to your doctor to determine if Shiltrone is right for you.

How do I take Shiltrone?

You should take Shiltrone exactly as prescribed by your doctor. It is typically taken by mouth once or twice a day with or without food. Depending on your specific needs, your doctor may also prescribe the drug to be given as a rectal injection or as an intravenous injection.

What if I miss a dose of Shiltrone?

If you miss a dose of Shiltrone, you should take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take double doses of Shiltrone to make up for a forgotten dose.

Can I take Shiltrone with other medications?

You should always consult your doctor before taking Shiltrone with any other medications. Certain drugs may interact with Shiltrone and cause serious side effects, so it is important to make sure that your medications are safe to take together.

What if I take too much Shiltrone?

If you have taken too much Shiltrone, you should contact your doctor or poison control immediately for advice. Symptoms of an overdose of Shiltrone include confusion, nausea, vomiting, and drowsiness.

Is Shiltrone safe for pregnant women?

It is not known if Shiltrone is safe for pregnant women to take. You should always talk to your doctor before taking any medication, especially if you are pregnant or breastfeeding.

Are there any other medications I should avoid while taking Shiltrone?

There are certain medications that you should avoid while taking Shiltrone as they can interact with the drug and cause serious side effects. Examples of medications to avoid include certain antibiotics, antifungals, antidepressants, and medications for allergies, colds, and heartburn.

What other forms does Shiltrone come in?

Shiltrone is available in oral tablets, rectal suppositories, and intravenous injections. Your doctor will prescribe the form that is best suited for your specific needs.

Does Shiltrone have any interactions with food or beverages?

Shiltrone can be taken with food or on an empty stomach, so there are no specific food or beverage interactions. However, as with all medications, it is best to consult your doctor before taking Shiltrone with any food or beverage.

Can Shiltrone be used to treat nausea and vomiting from other causes?

Shiltrone is only indicated for the prevention of nausea and vomiting from chemotherapy or radiation treatments. It is not intended for use in the treatment of any other cause of nausea or vomiting.

Can Shiltrone be used to treat pain?

No, Shiltrone is not indicated for the treatment of pain. It is only intended for the prevention of nausea and vomiting from chemotherapy or radiation treatments.

Can I drink alcohol while taking Shiltrone?

You should avoid drinking alcohol while taking Shiltrone as it can increase the risk of side effects. Always talk to your doctor before drinking alcohol while taking Shiltrone.

How long does it take for Shiltrone to work?

Shiltrone usually starts to work within 1-2 hours of taking the medication. However, it may take several days or weeks for you to experience the full effects of Shiltrone.

Can Shiltrone be used for children?

Yes, Shiltrone is FDA-approved for use in children aged 6 and older. However, the dosage and administration of Shiltrone may vary depending on your child's age, weight, and other medical factors, so talk to your doctor about the best dosing instructions for your child.

Can Shiltrone be used for long-term prevention of nausea and vomiting?

Shiltrone may be used for long-term prevention of nausea and vomiting associated with chemotherapy or radiation in some patients. Talk to your doctor to determine if Shiltrone is right for you.

Can Shiltrone be used to treat motion sickness?

No, Shiltrone is not indicated for the prevention or treatment of motion sickness. Talk to your doctor for other medications that may be suitable for treating or preventing motion sickness.

Can Shiltrone be used to treat nausea during pregnancy?

No, Shiltrone is not indicated for the treatment of nausea or vomiting during pregnancy. Talk to your doctor about other safe medications that you can take to treat your symptoms during pregnancy.

How long can I take Shiltrone?

The length of time you can take Shiltrone will depend on your specific needs and your doctor's instructions. Talk to your doctor to determine how long you should continue taking Shiltrone.

Can I take Shiltrone if I have kidney or liver disease?

Shiltrone may be used in some patients with kidney or liver disease, however, the dosage may need to be adjusted if you have any kidney or liver problems. Talk to your doctor to determine if Shiltrone is safe for you to take.

What should I do if I experience an allergic reaction to Shiltrone?

If you experience any symptoms of an allergic reaction, such as rash, difficulty breathing, itching, swelling of the face, lips, tongue, or throat, or tightness in the chest, you should seek immediate medical attention. Stop taking Shiltrone and contact your doctor.

Can I take Shiltrone with other antiemetics?

You should always consult your doctor before taking Shiltrone with any other medications, including other antiemetics. Certain medications may interact with Shiltrone and cause serious side effects, so it is important to make sure that your medications are safe to take together.

How long will Shiltrone stay in my system?

The amount of time that Shiltrone will stay in your system will depend on several factors, including your metabolism and kidney and liver function. Generally, the effects of Shiltrone last for several hours, up to 1 day.

Can I drive or operate machinery while taking Shiltrone?

It is best to avoid operating any heavy machinery or driving while taking Shiltrone as it may cause drowsiness or dizziness. If you do need to drive, it is important to be aware of your symptoms and take frequent breaks to ensure your safety.

Can Shiltrone be used to relieve nausea associated with morning sickness?

No, Shiltrone is not indicated for the prevention or treatment of morning sickness. Talk to your doctor for other medications that may be suitable for treating or preventing morning sickness.

Will Shiltrone cause weight gain?

Shiltrone is not known to cause weight gain, however, some people may experience an increase in appetite while taking the medication, which could lead to weight gain. Talk to your doctor if you have any concerns about your weight.

Can I take Shiltrone if I have a history of seizures?

Shiltrone may be used in some patients with a history of seizures, however, you should always talk to your doctor about your medical history and any other medications you are taking before taking Shiltrone. Your doctor will determine if it is safe for you to take the medication.

Can I take Shiltrone with other antinausea medications?

You should always consult your doctor before taking Shiltrone with any other medications, including other antinausea medications. Certain medications may interact with Shiltrone and cause serious side effects, so it is important to make sure that your medications are safe to take together.

Can I take Shiltrone with my other medications?

You should always consult your doctor before taking Shiltrone with any other medications. Certain drugs may interact with Shiltrone and cause serious side effects, so it is important to make sure that your medications are safe to take together.

What are signs that Shiltrone is not working?

If Shiltrone is not working as well as it should, you may experience worsening of your symptoms of nausea and vomiting. If this occurs, contact your doctor and report your symptoms so that they can adjust your dosage or change your medication.

What should I do if Shiltrone does not relieve my nausea and vomiting?

If Shiltrone does not adequately relieve your nausea and vomiting, contact your doctor. He or she may be able to adjust your dosage or provide a different medication to better suit your needs.

What other factors can affect how well Shiltrone works?

Your age, weight, overall health, kidney and liver function, and other medications you are taking can all affect how well Shiltrone works for you. It is important to talk to your doctor about your medical history and current medications to ensure that Shiltrone is the best choice for you.

What laboratory tests may be affected by Shiltrone?

Shiltrone may affect the results of certain laboratory tests, including liver function tests. It is important to tell your doctor about any medications you are taking, including Shiltrone, before any laboratory tests.

Does Shiltrone have any interactions with dietary supplements?

Shiltrone may interact with certain dietary supplements and herbal remedies. It is important to talk to your doctor before taking any dietary supplements or herbal remedies, as they may interact with Shiltrone and cause serious side effects.

Is there a generic version of Shiltrone available?

Yes, a generic version of Shiltrone is available in the United States. It is important to note that the generic version may not be available in all countries.