Semaglutide
Semaglutide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Semaglutide is a brand name. Its generic name is Semaglutide.
Semaglutide
Semaglutide is a medication used to treat type 2 diabetes in adults. It is a glucagon-like peptide-1 (GLP-1) receptor agonist, which works by stimulating insulin secretion and suppressing glucagon secretion in a glucose-dependent manner.
Uses For
Semaglutide is used to improve glycemic control in adults with type 2 diabetes. It is used in combination with exercise and diet to improve blood sugar levels.
Mechanism of Action
Semaglutide works by stimulating insulin secretion and suppressing glucagon secretion in a glucose-dependent manner. This results in increased glucose uptake in skeletal muscle and decreased glucagon release, which leads to lower glucose levels. It also increases the number of beta cells, which produce insulin. It may also reduce appetite and food intake.
How Long Does it Take to Work?
The effects of semaglutide on glycemic control are typically observed within one to two weeks, and the maximum benefit is typically seen between four to eight weeks. Results may vary depending on a patient's health condition.
Absorption, Route of Elimination, Dosage, Administration
Semaglutide is administered by subcutaneous injection once daily at any time of the day, preferably at the same time each day. The dosage range is 0.06–0.3 mg/day, with a maximum dose of 0.45 mg/day. Semaglutide is almost completely absorbed in the G.I tract, and typically has maximum plasma concentrations within seven hours of administration. It is mostly metabolized in the liver and eliminated from the body primarily through the kidneys.
Side Effects
Common side effects of semaglutide include nausea, diarrhea, headache, decreased appetite, fatigue, abdominal pain, and constipation. More serious side effects include increased risk of pancreatitis, increased risk of thyroid C-cell tumors, and decreased kidney function.
Toxicity, Precaution and Interaction
The likelihood of serious toxicity with semaglutide is very low. Patients should inform their doctor of any other medications, vitamins, or supplements they are taking prior to the start of semaglutide to check for any potential interactions. Patients should also be wary of drinking alcohol while taking semaglutide as it may increase the risk of severe hypoglycemia.
Disease Interaction, Drug Interaction, Food Interactions, Pregnancy Use, Lactation Use
Drug interactions, food interactions, and pregnancy and lactation use should all be discussed with a healthcare professional before beginning semaglutide.
Acute Overdose
The effects of an acute overdose of semaglutide may include hypoglycemia, nausea, vomiting, abdominal pain, tachycardia, and headache. Treatment should consist of administering or correcting the hypoglycemia with an appropriate sugar source, and supportive measures.
Contraindication
Semaglutide is contraindicated in patients with a previous history of a pancreatic disorder, severe renal impairment, and uncontrolled hypertension. It is also not recommended for use in patients with type 1 diabetes, or in combination with meal-time insulin.
Use Direction, Storage Condition, Volume of Distribution, Half Life, Clearance
Semaglutide should be administered once daily subcutaneously at any time of the day, preferably at the same time each day. The dosage range is 0.06–0.3 mg/day, with a maximum dose of 0.45 mg/day. The medication should be stored at room temperature (20-25°C), away from light, and out of reach of children. It has a distribution volume of 8.2 - 12.3 L, a half-life of 1.8 to 2.6 hours, and an estimated clearance of 16.1 - 20.1 L/h.
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