(S)-alpha-Methyltyrosine
(S)-alpha-Methyltyrosine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? (S)-alpha-Methyltyrosine is a brand name. Its generic name is Metyrosine.
(S)-alpha-Methyltyrosine
(S)-alpha-Methyltyrosine is a drug used for the treatment of certain types of high blood pressure and tumors in the adrenal glands. It is also used as an adjunct in the management of hormonal imbalances in the central nervous system, such as the syndrome of inappropriate antidiuretic hormone (SIADH).
Uses for
(S)-alpha-Methyltyrosine is used for treating inoperable cases of pheochromocytoma, a rare tumor of the adrenal glands that can cause high blood pressure, abdominal pain, and palpitations. It is also used to treat certain types of hypertension that have been unresponsive to other medications. Additionally, it can be used to treat certain central nervous system disorders caused by hormonal imbalances.
Mechanism of Action
(S)-alpha-Methyltyrosine works by blocking the action of certain hormones which are responsible for the production of the hormone, dopamine. It also inhibits the enzyme tyrosine hydroxylase, which is responsible for the production of the neurotransmitters, norepinephrine and epinephrine. By doing this, it helps to decrease blood pressure and the production of hormones in the central nervous system.
How Long Does It Take To Work?
The effects of (S)-alpha-Methyltyrosine can generally be seen between 8-12 hours after the first dose. However, it may take several doses and longer amount of time for improvement in symptoms.
Absorption
(S)-alpha-Methyltyrosine is rapidly absorbed from the gastrointestinal tract, reaching peak concentrations in 1-2 hours.
Route of Elimination
(S)-alpha-Methyltyrosine is mainly metabolized by the liver and is excreted in the urine.
Dosage
The recommended dose of (S)-alpha-Methyltyrosine is 250-500 mg twice a day (taken with meals). The dose can be adjusted according to the individual’s response and the severity of the condition.
Administration
(S)-alpha-Methyltyrosine is available as a tablet and should be taken orally. It is important to take (S)-alpha-Methyltyrosine with meals to reduce the risk of stomach upset.
Side Effect
Common side effects from (S)-alpha-Methyltyrosine include nausea, vomiting, headache, dizziness, insomnia, and restlessness. Other less common but potentially serious side effects include liver damage, kidney damage, and an increase in blood pressure.
Toxicity
(S)-alpha-Methyltyrosine is generally well tolerated, however, toxicity can occur if taken in large doses or if combined with certain other medications. In cases of overdose, it is important to seek immediate medical attention.
Precaution
Before taking (S)-alpha-Methyltyrosine, it is important to tell your doctor if you have any history of liver, kidney, or heart disease; or if you are pregnant or breastfeeding. It is also important to inform your doctor of any other medications or supplements you are taking.
Interaction
(S)-alpha-Methyltyrosine may interact with certain medications, such as MAO inhibitors and diuretics. Therefore, it is important to inform your doctor of any other medications or supplements you are taking before taking (S)-alpha-Methyltyrosine.
Disease Interaction
(S)-alpha-Methyltyrosine should not be taken if you have liver, kidney or heart disease, or if you are pregnant or breastfeeding. It is also important to inform your doctor of any other diseases or medical conditions you have before taking (S)-alpha-Methyltyrosine.
Drug Interaction
(S)-alpha-Methyltyrosine may interact with certain medications, such as MAO inhibitors, tricyclic antidepressants, and certain diuretics. Therefore, it is important to inform your doctor of any other medications or supplements you are taking before taking (S)-alpha-Methyltyrosine.
Food Interactions
(S)-alpha-Methyltyrosine should be taken with meals to reduce the risk of stomach upset. Grapefruit juice and dairy products should be avoided while taking (S)-alpha-Methyltyrosine.
Pregnancy Use
(S)-alpha-Methyltyrosine is not recommended for use in pregnant women. It is important to inform your doctor if you are pregnant or trying to become pregnant before taking (S)-alpha-Methyltyrosine.
Lactation Use
(S)-alpha-Methyltyrosine is not recommended for use in breastfeeding mothers. It is important to inform your doctor if you are breastfeeding before taking (S)-alpha-Methyltyrosine.
Acute Overdose
If an overdose of (S)-alpha-Methyltyrosine is suspected, it is important to seek immediate medical attention. Symptoms of an overdose may include agitation, confusion, dizziness, drowsiness, and tremors.
Contraindication
(S)-alpha-Methyltyrosine should not be taken if you have liver, kidney, or heart disease, or if you are pregnant or breastfeeding. It is also important to inform your doctor of any other diseases or conditions you have before taking (S)-alpha-Methyltyrosine.
Use Direction
(S)-alpha-Methyltyrosine should be taken as directed by your doctor. The recommended dose is 250-500 mg twice a day (taken with meals). The dose can be adjusted according to the individual’s response and the severity of the condition.
Storage Condition
(S)-alpha-Methyltyrosine should be stored at room temperature and away from moisture and heat. Keep away from children and pets.
Volume of Distribution
(S)-alpha-Methyltyrosine has a volume of distribution of approximately 20 liters.
Half Life
(S)-alpha-Methyltyrosine has a half life of approximately 3 hours.
Clearance
(S)-alpha-Methyltyrosine has a clearance of approximately 4 liters per hour.
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