Ritomune

Ritomune Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ritomune is a brand name. Its generic name is Ritonavir.

Introduction

Ritomune is an antiretroviral (ARV) medication, which is used in the treatment of HIV/AIDS. It is a protease inhibitor, and is used in combination with other medications to decrease the amount of HIV in the body and reduce the risk of developing AIDS-related illnesses. It is a viral enzyme inhibitor that works by blocking HIV reverse transcriptase from replicating on the genetic material of the virus.

Uses

Ritomune is used to treat HIV infections in adults. It is usually prescribed in combination with two other substances, often called "HAART" (Highly Active Antiretroviral Therapy). These other treatments may include nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and other inhibitors. When used in combination with other medications, ritonavir can reduce HIV replication in the body and slow the progression of the virus.

Mechanism of Action

Ritomune works by blocking the activity of the HIV reverse transcriptase enzyme, which is responsible for replication of the virus. By blocking this enzyme, ritonavir can prevent the virus from making copies of itself and this reduces the amount of HIV circulating in the body. This helps to reduce the risk of developing AIDS-related illnesses and prolongs the life of those infected with HIV.

How Long Does it Take to Work?

Ritomune has a rapid onset of action. The virus is usually reduced within 48 hours of taking the medication, and the effects continue to be felt over the duration of treatment as long as it is taken correctly.

Absorption

Ritomune is absorbed quickly through the gastrointestinal tract. Peak plasma levels of the drug are reached within 1 to 3 hours after ingestion.

Route of Elimination

Ritomune is mainly eliminated from the body via the liver and the kidneys. Around 95% is eliminated via the liver and the remaining 5% is eliminated via the kidneys.

Dosage

Dosage for adults and adolescents is usually based on body weight and infection severity. The usual daily dose ranges from 200 mg to 400 mg taken twice daily or in divided doses. For children, the recommended dosage is based on the child's body weight.

Administration

Ritomune is usually taken orally as a tablet or capsule with at least 8 ounces of water. It should be taken with food to increase absorption and reduce the risk of stomach upset.

Side Effects

Common side effects of ritonavir include nausea, vomiting, loss of appetite, diarrhoea, headache, fatigue, dizziness, rash and an increased risk of developing skin cancer.

Toxicity

Ritomune has a high potential for toxicity. Overdosing on the drug can lead to serious effects on the liver and kidneys and can cause anemia, kidney failure, and even death.

Precautions

• Before starting treatment with ritonavir, tell your doctor if you have any medical conditions, particularly liver or kidney problems, or if you are pregnant, planning to become pregnant or breastfeeding. • This medication can interact with other medications and can cause serious side effects when taken with certain other medications. Be sure to tell your doctor about all the medications you are taking. • Ritomune can cause dizziness. Do not drive or perform any activity that requires alertness until you know how this medication affects you.

Interaction

Ritomune can interact with several other medications and can potentially cause serious side effects. These include anticoagulants, antihypertensive drugs, anticonvulsants, benzodiazepines, cimetidine, cyclosporine, diuretics, ergot alkaloids, HIV protease inhibitors, insulin, macrolide antibiotics, MAO inhibitors, oral contraceptives, opioids, phenothiazines, selective serotonin reuptake inhibitors (SSRIs), steroids, sulfonamides, other antiviral agents, and theophylline.

Disease Interactions

Ritomune interacts with a variety of other medical conditions including liver disease, kidney disease, anemia, diabetes, and women who are pregnant, planning to become pregnant or breastfeeding. Be sure to inform your doctor about any disease or condition you are experiencing in order to avoid adverse interactions.

Drug Interactions

Ritomune interacts with several other medications and can potentially cause serious side effects. These include anticoagulants, antihypertensive drugs, anticonvulsants, benzodiazepines, cimetidine, cyclosporine, diuretics, ergot alkaloids, HIV protease inhibitors, insulin, macrolide antibiotics, MAO inhibitors, oral contraceptives, opioids, phenothiazines, selective serotonin reuptake inhibitors (SSRIs), steroids, sulfonamides, other antiviral agents, and theophylline.

Food Interactions

Food does not have an effect on the absorption of ritonavir. However, foods high in fat can temporarily increase the absorption levels of the drug. Therefore, it is best to take ritonavir with a meal or snack that is lower in fat.

Pregnancy Use

Ritomune is generally not recommended for use in pregnant women, as its safety has not been established. Women who are pregnant or become pregnant while taking this medication should immediately inform their doctor.

Lactation Use

Ritomune is generally not recommended for use in breastfeeding women, as its safety has not been established. Women who are breastfeeding or become pregnant while taking this medication should immediately inform their doctor.

Acute Overdose

If an overdose of ritonavir is suspected, contact an emergency room right away. Symptoms of overdose can include nausea, vomiting, confusion, lightheadedness, drowsiness, and difficulty breathing.

Contraindication

Ritomune is contraindicated in patients who are hypersensitive to it or to any of its components, as well as in patients with a history of liver, kidney, or heart damage.

Use Directions

Ritomune should be taken exactly as prescribed by your doctor. It is usually taken orally with meal or snack to increase absorption and reduce the risk of stomach upset. Do not take more or less of this medication than prescribed.

Storage Conditions

Ritomune should be stored at room temperature away from moisture, heat, and light.

Volume of Distribution

The volume of distribution of ritonavir is 6-8 L/kg.

Half Life

The half-life of ritonavir is approximately 3-5 hours.

Clearance

The clearance of ritonavir is approximately 1.2-2 L/h.

Here you find in details version of Ritomune

Some Frequently Asked Questions About Ritomune

https://www.medicinesfaq.com/brand/ritomune, , , https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45409, http://www.hmdb.ca/metabolites/HMDB0014646, http://www.genome.jp/dbget-bin/www_bget?drug:D00427, http://www.genome.jp/dbget-bin/www_bget?cpd:C07240, https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=392622, https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505050, https://www.chemspider.com/Chemical-Structure.347980.html, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520, https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=85762, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=45409, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL163, https://zinc.docking.org/substances/ZINC000003944422, http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000169, http://www.pharmgkb.org/drug/PA451260, https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/RIT, http://www.rxlist.com/cgi/generic2/ritonavirsol.htm, https://www.drugs.com/cdi/ritonavir.html, https://en.wikipedia.org/wiki/Ritonavir,