Retarel
Retarel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Retarel is a brand name. Its generic name is Retapamulin.
Retarel Introduction
Retarel is an antibacterial drug in the ionophore class that is used to treat certain skin infections, including impetigo. It is the first of a new class of agents to become available for use in treating such skin conditions, and it has been shown to be effective against a range of bacteria responsible for skin infections.Uses for Retarel
Retarel is indicated for the topical treatment of impetigo in patients two months of age and older. It is effective at treating a range of bacteria responsible for skin infections, including common S. aureus and non-multidrug-resistant S. pyogenes.Mechanism of Action
Retarel works by inhibiting bacterial protein synthesis, causing a decreased rate of bacterial growth and eventual death. It works by binding to and blocking the action of the bacterial ribosome, a specialized organelle responsible for protein synthesis.How Long Does it Take to Work?
It typically takes 6-7 days for Retarel to start working. This timeframe may vary depending on the severity and type of infection.Absorption
Retarel is minimally absorbed through the skin, with only about 0.6-2.9% of a topical dose reaching the systemic circulation.Route of Elimination
Retarel is eliminated primarily through the feces. It is rapidly cleared from the systemic circulation, with a half-life of approximately 2-3 hours.Dosage
The recommended dosage of topical Retarel is as follows: Adults, adolescents, and children 9 years of age or older with a body weight greater than 50 kg: Apply a thin layer of ointment twice daily (about 12 hours apart) and spread evenly over the entire infected area or as directed by a healthcare professional. Allow the ointment to remain on the skin for at least 8 hours before washing the treated area. Children 2 months to 9 years of age and body weight greater than 25 kg: Apply a thin layer of ointment once daily (preferably in the evening) and spread evenly over the entire infected area or as directed by a healthcare professional. Allow the ointment to remain on the skin for at least 8 hours before washing the treated area.Administration
Retarel is a topical ointment that should be applied directly to the affected area twice daily (for adults and children older than 9 years) or once daily (for children 2 months to 9 years of age). It should be applied directly to the lesion and not rubbed in.Side Effects
Common side effects of Retarel include itching, soreness, burning, and stinging in the affected area, as well as skin dryness, redness, or flaking. In some cases, particularly if the medication is used for a long period of time or in high doses, it can also cause hypersensitivity reactions.Toxicity
Retarel has an excellent safety profile and is not associated with serious toxicity. It is minimally absorbed through the skin and is rapidly cleared from the body after topical administration.Precautions
Retarel is for topical use only and should not be taken orally or via injection. It should not be used on open wounds or in the eyes, ears, nose, or mouth. It should not be used if the skin is irritated or abraded, and it should not be applied to excessively large areas of skin.Interactions
Retarel should not be used with other topical medications applied to the same area. Additionally, it should not be used with other antibacterial topical medications or topical steroids.Disease Interactions
Retarel should be used with caution in patients with renal or hepatic impairment, as well as in patients who are immunocompromised. It should also not be used in patients with a history of hypersensitivity to mupirocin, as it contains mupirocin as an active ingredient.Drug Interactions
Retarel has no known drug interactions.Food Interactions
Retarel has no known food interactions.Pregnancy Use
Retarel should not be used by pregnant women unless the potential benefits outweigh the potential risks.Lactation Use
Retarel should not be used by nursing women unless the potential benefits outweigh the potential risks.Acute Overdose
Retarel is minimally absorbed through the skin, so an acute overdose is unlikely to occur.Contraindication
Retarel should not be used on open wounds or in the eyes, ears, nose, or mouth. Additionally, it should not be used if the skin is irritated or abrased. It should also not be used in patients with a history of hypersensitivity to mupirocin, as it contains mupirocin as an active ingredient.Use Directions
Retarel should be applied directly to the lesion and not rubbed in. It should not be applied to excessively large areas of skin. Adults, adolescents, and children 9 years of age or older with a body weight greater than 50 kg should apply a thin layer of ointment twice daily (about 12 hours apart) and spread evenly over the entire infected area. Children 2 months to 9 years of age and body weight greater than 25 kg should apply the ointment once daily (preferably in the evening) and spread evenly over the entire infected area. Allow the ointment to remain on the skin for at least 8 hours before washing the treated area.Storage Conditions
Retarel should be stored at room temperature between 15-30°C.Volume of Distribution
Retarel has a volume of distribution of 2.9 L/kg.Half Life
The half life of Retarel is approximately 2-3 hours.Clearance
Retarel is rapidly cleared from the systemic circulation, with a clearance rate of approximately 0.54 L/hr/kg.Here you find in details version of Retarel
Some Frequently Asked Questions About Retarel
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