Renesa
Renesa Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Renesa is a brand name. Its generic name is Aliskiren.
Renesa Introduction
Renesa is a medication used to treat high blood pressure. It is a direct renin inhibitor (DRI), which blocks the action of renin, an enzyme released from the kidneys to regulate blood pressure. By blocking renin, aliskiren helps reduce blood pressure in both adults and adolescents. It is usually prescribed in combination with other blood pressure medications, such as hydrochlorothiazide (HCTZ), for maximum effectiveness.Uses for Renesa
Renesa is used to treat hypertension (high blood pressure) in adults and adolescents over 12 years old. It is typically used in combination with other anti-hypertensive medications as part of a comprehensive therapy plan. Renesa is also used to reduce the risk of stroke, heart attack, congestive heart failure, and other complications associated with hypertension.Mechanism of Action
Renesa works by blocking the action of renin, an enzyme released from the kidneys. Renin plays an important role in blood pressure regulation, so by blocking it, aliskiren helps to reduce blood pressure. Renesa blocks the binding of renin to the receptor sites, which prevents it from activating the nerve cells that control blood pressure.How long does it take to work?
Renesa starts to work within hours of ingestion. Its full effect can be seen within one to two weeks of beginning treatment. However, it may take several weeks or months for the blood pressure to be reduced to target levels.Absorption
Renesa is rapidly absorbed from the gastrointestinal tract after oral administration. The peak concentration in the bloodstream is reached within 1-3 hours.Route of Elimination
Renesa is excreted in both urine and feces, with about 85% being excreted in the urine and the remaining 15% in the feces.Dosage, Administration, Side Effects and Toxicity
The usual starting dose for aliskiren is 50 to 100 milligrams once daily, taken orally with or without food. The dose may be increased by your healthcare provider up to 300 milligrams per day, as needed. Renesa may cause side effects, such as dizziness, weakness, headache, and nausea. If these effects persist or worsen, contact your doctor immediately. Renesa is generally safe and well-tolerated. Overdose can cause dangerously low blood pressure, so contact your doctor immediately if you think you may have taken too much.Precautions and Interactions
Before starting treatment with aliskiren, talk to your healthcare provider about any other medications you are taking, as well as any associated conditions, such as diabetes or an impaired kidney or liver. Renesa can interact with certain medications, so it is important to tell your doctor about all the medications you are taking before starting treatment.Disease Interaction
Renesa should not be used in patients with a known hypersensitivity to the drug. It is also not recommended for patients with certain kidney or liver conditions, pre-existing conditions, or pregnancy.Drug Interactions
Renesa can interact with certain medications and reduce their efficacy. It is important to tell your doctor about all medications you are taking before starting aliskiren. Specifically, it can interact with diuretics, non-steroidal anti-inflammatory drugs, and certain antibiotics.Food Interaction
Renesa should be taken with food in order to reduce the risk of low blood pressure. Avoid eating large amounts of grapefruit or drinking grapefruit juice while taking aliskiren, as this may increase the risk of side effects.Pregnancy and Lactation
Renesa should be used with caution in pregnant women. Women who are pregnant or planning to become pregnant should talk to their doctor before taking aliskiren. Renesa is excreted into breast milk and should be used with caution in nursing mothers.Acute Overdose
Signs of an overdose include low blood pressure, dizziness, and fatigue. If you suspect an overdose, contact your healthcare provider immediately.Contraindication
Renesa should not be used in patients with an allergy or hypersensitivity to aliskiren or any of its components. It is also not recommended for use in patients with certain kidney or liver conditions, or those who are pregnant. Before beginning treatment, your doctor should screen you for any pre-existing conditions.Use Directions
Renesa should be taken orally once daily at the same time each day. Do not exceed the recommended dose or take more than 300 milligrams per day.Storage Condition
Renesa should be stored at room temperature (59-86°F). Keep the medication in its original container and away from light and moisture.Volume of Distribution
The volume of distribution of aliskiren is approximately 11 L/kg.Half Life
The half-life of aliskiren is approximately 3.4 hours.Clearance
The clearance of aliskiren is approximately 1.4 mL/min/kg.Here you find in details version of Renesa
Some Frequently Asked Questions About Renesa
https://www.medicinesfaq.com/brand/renesa,
,
,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:601027,
http://www.hmdb.ca/metabolites/HMDB0015387,
http://www.genome.jp/dbget-bin/www_bget?drug:D03208,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5493444,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264980,
https://www.chemspider.com/Chemical-Structure.4591452.html,
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17950,
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=325646,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=601027,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1639,
https://zinc.docking.org/substances/ZINC000004393164,
http://www.pharmgkb.org/drug/PA143487910,
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/C41,
https://www.drugs.com/cdi/aliskiren.html,
https://en.wikipedia.org/wiki/Aliskiren,