Regulate
Regulate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Regulate is a brand name. Its generic name is Norethisterone.
Regulate
Regulate (NET) is a synthetic progestogen used in hormonal contraceptives and for treating certain menstrual problems. It is a synthetic hormone closely related to progesterone and acts by preventing ovulation and/or suppressing the effects of estrogen on target tissues.
Uses For
Regulate is used in combination with estrogen-containing products to regulate the menstrual cycle and to treat menopausal symptoms. It has also been used to manage certain menstrual conditions, such as endometriosis, premenstrual syndrome, and abnormally heavy bleeding.
Mechanism of Action
Regulate binds to progesterone receptors in the body, thereby blocking the effect of the estrogen on target tissues. It also suppresses the activity of the hypothalamic–pituitary–ovarian axis, preventing the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), which is necessary for ovulation.
How Long Does It Take to Work?
Regulate usually begins to work within a few hours of taking it. If taken with estrogen, it generally takes a few days for the full hormonal effect to be achieved.
Absorption
Regulate is readily absorbed via the gastrointestinal tract after oral administration, but its bioavailability can be decreased somewhat when taken concomitantly with certain food and medicines.
Route of Elimination
Regulate is primarily metabolized in the liver and excreted in the urine. Its metabolites are eliminated via the bile.
Dosage
The dosage of norethisterone to treat menstrual conditions should be determined by a health care provider. Typical dosages range from 1-5mg taken daily for the duration of the treatment regimen.
Administration
Regulate is typically administered as a tablet taken orally once daily, with or without food. This may be increased to two tablets each day as needed. The tablets should be swallowed whole and should not be crushed or otherwise disrupted prior to ingestion.
Side Effect
Common side effects associated with norethisterone therapy include nausea, vomiting, headaches, breast tenderness, fluid retention, and acne. Rarely, serious adverse effects, such as blood clots, stroke, and deep vein thrombosis, have been reported.
Toxicity
Regulate is generally well-tolerated. Prolonged use of high doses has been associated with symptoms of hyperprogesteronism, such as anovulation, edema, weight gain, amenorrhea, and depression. It should only be used when medically indicated and under the close supervision of a health care provider.
Precautions
Regulate should not be used in women with a history of breast or uterine cancer, thromboembolic disorders, and/or hepatic dysfunction. It should also be used with caution in those taking other medications, such as anticoagulants, corticosteroids, and antidiabetic agents.
Interaction
Regulate can interact with other medications, such as anticoagulants, corticosteroids, and antidiabetic agents. It can also interact with some foods, such as alcohol, tobacco, and certain herbal supplements, or with certain diseases, such as kidney or liver disease.
Disease Interaction
Regulate can interact with certain diseases, such as kidney or liver disease, increasing the risk of potential side effects and adverse reactions. Women with these types of diseases should be closely monitored by their doctors while taking norethisterone.
Drug Interaction
Regulate can interact with other medications, such as anticoagulants, corticosteroids, and antidiabetic agents, as well as with certain herbal supplements. These interactions may increase the risk of potential side effects and adverse reactions. Women taking these medications should be closely monitored by their doctors while taking norethisterone.
Food Interactions
Regulate can interact with certain foods, such as alcohol, tobacco, and certain herbal supplements. These interactions may decrease the effectiveness of norethisterone or increase the risk of potential side effects and adverse reactions. Women should avoid or limit these foods while taking norethisterone.
Pregnancy Use
Regulate should not be used during pregnancy or while breast-feeding. If pregnancy occurs during treatment, women should contact their healthcare provider immediately.
Lactation Use
Regulate should not be used during lactation, as it may be excreted in breast milk and may cause adverse reactions to the baby. Women should contact their healthcare provider for guidance if they are breast-feeding while taking norethisterone.
Acute Overdose
An acute overdose of norethisterone is unlikely to cause serious harm. Symptoms of an overdose may include nausea, vomiting, diarrhea, and/or dizziness. If an overdose is suspected, contact a poison control center immediately.
Contraindication
Regulate is contraindicated in women with a history of breast or uterine cancer, thromboembolic disorders, and/or hepatic dysfunction. Women with these conditions should not use norethisterone.
Use Directions
Regulate should be taken exactly as prescribed by a health care provider. The tablets should be swallowed whole and should not be crushed or otherwise disrupted prior to ingestion. Women should take norethisterone at the same time each day to maintain a consistent level of the drug in the body.
Storage Condition
Regulate should be stored in a cool, dry place away from direct light, moisture, and heat. Shelf life is usually two to three years, depending on the product packaging.
Volume of Distribution
The volume of distribution of norethisterone is approximately 5 liters/kg. This means that the drug is dispersed throughout the body in this volume, as opposed to being highly concentrated in one area.
Half Life
The half-life of norethisterone is between 7 and 10 hours. This means that half of the dose is eliminated from the body within this time period.
Clearance
The clearance of norethisterone is approximately 0.7 liters/kg/hour. This means that every hour, on average 0.7 liters of the drug is eliminated from the body.
Here you find in details version of Regulate
Some Frequently Asked Questions About Regulate
What is Regulate?
Regulate is a type of synthetic female hormone which is consumed orally and is mainly used to treat menstrual disorders.
What are the common uses of Regulate?
Regulate is typically used to help regulate irregular menstrual cycles, treat severe menstrual pain or endometriosis, and to delay your period.
Is Regulate an effective treatment for PMS?
Yes, Regulate is a very effective treatment for PMS. Studies have shown that it can reduce the symptoms associated with PMS, such as irritability, mood swings, breast tenderness, and fatigue.
What are the side effects of Regulate?
Side effects of Regulate may include abdominal pain, nausea, headache, weight gain, and breast tenderness. In some rare cases, severe side effects such as liver problems, depression, and strokes may be experienced.
Can Regulate be taken while breastfeeding?
No, Regulate should not be taken while breastfeeding due to risks of adverse side effects. It is advised to wait until breastfeeding has ceased before taking this medication.
What is the recommended dosage of Regulate?
The recommended dosage of Regulate is 5mg taken three times a day. It is important to consult your doctor to ensure this is the right dosage for your individual needs.
How soon will I experience relief from my menstrual symptoms after taking Regulate?
The effects of Regulate can be seen within the first few weeks of taking this medication. However, it is important to note that symptoms may continue to improve over time.
Can Regulate be used for contraception?
No, Regulate should not be used as a form of contraception. It is intended to treat menstrual disorders and should not be used as a method of contraception.
Should I take Regulate every day?
No, Regulate should only be taken as recommended by your doctor. If you are taking it to treat menstrual disorders, your doctor will likely recommend taking it every day for a certain period of time before your period is expected to start.
Does Regulate affect fertility?
No, Regulate does not affect fertility. Studies have shown that it can actually help regulate the menstrual cycle, which in turn may improve the frequency of ovulation.
Would it be safe to use Regulate if I have a family history of breast cancer?
It is recommended to consult a doctor or health care provider before using Regulate if you have a family history of breast cancer. Your doctor would be best placed to advise if this medication is safe for you to use.
Is Regulate safe to use during pregnancy?
No, Regulate is not safe to use during pregnancy. If you suspect you are pregnant, it is advised to stop taking this medication immediately and to seek medical advice.
Can I drink alcohol while taking Regulate?
It is not recommended to drink alcohol while taking Regulate, as it can interact with the medication and cause side effects. It is best to speak to your doctor before consuming alcohol while taking this medication.
Can I overdose on Regulate?
Yes, it is possible to overdose on Regulate. If you suspect an overdose, seek medical attention immediately.
What should I do if I miss a dose of Regulate?
If you miss a dose of Regulate, it is important to take the missed dose as soon as you remember. However, if it is nearly time for the next dose, it is best to skip the missed dose and take the next dose as scheduled.
Is it safe to use Regulate if I have a heart condition?
It is important to consult with a doctor prior to using Regulate if you have a heart condition. Your doctor will be able to assess if this medication is safe for you to take.
Can Regulate be used to treat endometriosis?
Yes, Regulate has been shown to be effective in treating symptoms associated with endometriosis. It can help reduce the symptoms of endometriosis, such as pain and heavy bleeding.
Can I take Regulate with other medications?
It is important to consult with a doctor or pharmacist prior to taking Regulate with other medications. Some medications can interact with Regulate, resulting in serious side effects.
Can I take Regulate while on birth control?
No, Regulate should not be taken while on birth control. It is important to first consult with a doctor or health care provider before taking this medication if you are already taking birth control.
What happens if I stop taking Regulate suddenly?
Stopping Regulate suddenly can result in uncomfortable withdrawal symptoms. It is important to consult with a doctor before stopping this medication to ensure it is safe and done gradually.
Does Regulate cause weight gain?
Yes, Regulate is known to cause weight gain, although this varies from person to person. It is recommended to speak to your doctor about ways to manage any weight gain caused by taking this medication.
Can I take Regulate to delay my period?
Yes, Regulate can be taken to delay your period. However, it is only suitable if you do not have any underlying health conditions. It is important to consult with a doctor before taking this medication for this purpose.
Does Regulate increase the risk of blood clots?
Yes, Regulate can increase the risk of blood clots. It is important to consult with a doctor before taking this medication if you have any existing problems with blood clotting.
Does Regulate interact with any herbal supplements?
Yes, Regulate has been known to interact with some herbal supplements. It is important to speak to a doctor or pharmacist before taking any herbal supplements while taking Regulate.
Is Regulate available in different strengths?
Yes, Regulate is available in different strengths. Your doctor will be able to recommend the right strength for you based on your individual needs.
Does Regulate affect libido?
Yes, Regulate can affect libido. If you experience decreased libido, it is important to consult your doctor as there may be other treatments available for your condition.
How long does it take for Regulate to take effect?
The effects of Regulate may start to be noticed within the first few weeks of taking this medication. However, it can take up to several months for the full effects of Regulate to be seen.
Can Regulate cause mood swings?
Yes, Regulate can cause mood swings. It is important to speak to a doctor or health care provider if you experience any changes in mood while taking this medication.
What are the long term effects of taking Regulate?
Long term use of Regulate can result in side effects such as abdominal pain, nausea, headache, weight gain, and breast tenderness. It is important to consult your doctor regularly while taking this medication.
Is Regulate available over the counter?
No, Regulate is only available with a prescription. It is important to consult with your doctor prior to taking this medication to ensure it is suitable and safe for you to use.
Does Regulate have any interaction with other drugs?
Yes, Regulate can interfere with other medications. It is important to speak to your doctor or pharmacist prior to taking this medication if you are taking any other drugs.
Can Regulate make my period more frequent?
Yes, taking Regulate can make your period more frequent. This is due to the hormones in the medication helping to regulate the menstrual cycle. It is important to speak to your doctor if you experience any changes in the frequency of your periods.
Can I take Regulate while trying to conceive?
No, Regulate should not be taken while trying to conceive. This medication is intended to interfere with hormones in the body, which can hinder fertility.
Will Regulate help relieve bloating?
Yes, Regulate can help reduce bloating. It can also help reduce heavy bleeding and reduce the amount of menstrual cramps experienced.
Can Regulate cause hair loss?
Yes, Regulate can cause hair loss in some people. It is important to speak to your doctor if you beginning to experience any changes in your hair.
What should I do if I experience an allergic reaction to Regulate?
If you experience an allergic reaction to Regulate, such as swelling, difficulty breathing, rash or hives, it is important to seek medical attention immediately.
Does Regulate affect cholesterol levels?
Yes, Regulate can affect cholesterol levels. It is advisable to monitor your cholesterol levels regularly while taking this medication.
Is Regulate suitable for teenagers?
No, Regulate is not suitable for people under the age of 18. It is important to speak to a doctor before taking this medication if you are under 18 years old.
Can I take Regulate while breastfeeding?
No, Regulate should not be taken while breastfeeding due to risks of adverse side effects. It is advised to wait until breastfeeding has ceased before taking this medication.
Will Regulate help reduce menstrual pain?
Yes, Regulate has been shown to help reduce menstrual pain and other symptoms associated with menstrual issues. It is important to consult your doctor about any changes in your menstrual cycle.
Will Regulate help with menstrual cramps?
Yes, Regulate can help with menstrual cramps. It is a hormone which helps to regulate the menstrual cycle, which can result in reduced menstrual cramps.
What are some of the long-term risks associated with taking Regulate?
Long-term risks associated with taking Regulate include an increased risk of blood clots, stroke, depression, and liver problems. It is important to consult with your doctor regularly while taking this medication.