Regorafenibum
Regorafenibum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Regorafenibum is a brand name. Its generic name is Regorafenib.
Regorafenibum Introduction
Regorafenibum is a small-molecule, multikinase inhibitor that has been approved by the U.S. Food and Drug Administration (FDA) to treat metastatic colorectal cancer (mCRC), gastrointestinal stromal tumors (GISTs) and hepatocellular carcinoma (HCC). It is designed to block multiple targets, including tumor growth factors, angiogenesis and downstream receptor pathways.
Uses For Regorafenibum
Regorafenibum is used to treat metastatic colorectal cancer (mCRC), gastrointestinal stromal tumors (GISTs) and hepatocellular carcinoma (HCC).
Mechanism of Action
Regorafenibum works by blocking multiple targets, including tumor growth factors, angiogenesis, and downstream receptor pathways. When these targets are blocked, it prevents the growth, spread and development of cancer cells.
How Long Does it Take to Work?
Regorafenibum begins to work within days to reduce cancer cell growth, however, it can take weeks to months to observe clinical benefits.
Absorption
Regorafenibum is rapidly and completely absorbed following oral dosing.
Route of Elimination
Regorafenibum is mainly eliminated by the liver via cytochrome P450 enzymes, with a minor excretory component.
Dosage
The recommended dose of Regorafenibum is 160 mg orally once daily for the first 21 days of a 28-day cycle. For cycles 2 and beyond, the dose may be adjusted depending on the patient's individual tolerability. The dose may be increased in 20 mg increments not to exceed a total daily dose of 240 mg.
Administration
Regorafenibum should be taken once daily, without food, at least one hour before or two hours after a meal. Swallow the tablets whole, accompanied by at least 240 mL of water.
Side Effects
Common side effects of regorafenib include fatigue, hand-foot syndrome, hypertension, diarrhea, mouth sores, anorexia, and decreased appetite. More serious side effects include liver damage, heart problems, and bon marrow suppression.
Toxicity
Regorafenibum is generally well-tolerated, however, it can cause toxicities which may decrease patient's quality of life, including changes in blood cell counts, severe skin reactions, and hand-foot syndrome.
Precaution
Regorafenibum should be used with caution in patients with a known history of cardiac problems, liver impairment, or other serious medical conditions. Patients should also be monitored for signs of liver or kidney problems including nausea, vomiting, abdominal pain, and dark urine and should be advised to promptly seek medical attention if they experience these symptoms.
Interactions
Regorafenibum may interact with other medications. Patients should inform their physician about other medications they are taking prior to starting Regorafenibum
Disease Interactions
Regorafenibum is contraindicated in patients with certain diseases, such as severe hepatic impairment, severe renal impairment, or those with neuropathy. Patients should discuss any pre-existing illnesses with their healthcare provider prior to starting treatment with Regorafenibum.
Drug Interactions
Regorafenibum may interact with certain drugs, such as anticoagulants, certain antibiotics, and other drugs that may affect liver enzymes. Patients should inform their physician of any prescription or over the counter medications they are taking prior to starting treatment with Regorafenibum.
Food Interactions
Regorafenibum should be taken without food, at least one hour before or two hours after a meal. Eating a high-fat meal prior to taking Regorafenibum should be avoided.
Pregnancy Use
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