Ranolazine
Ranolazine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ranolazine is a brand name. Its generic name is Ranolazine.
Introduction
Ranolazine is a medication used to treat chronic angina (chest pain). It works by increasing the amount of oxygen that is available to the heart muscle during periods of physical exertion and stress. It is usually given as an extended-release tablet that is taken twice a day.Uses
Ranolazine is used to treat chronic angina (chest pain) in adults. It works by increasing the amount of oxygen that is available to the heart muscle during periods of physical exertion and stress.Mechanism of Action
Ranolazine works by inhibiting the late sodium current. This reduces extrusion of calcium ions from cells within the heart muscle, which increases the amount of oxygen available to the heart muscle.How Long Does It Take to Work?
The effects of Ranolazine may be seen within a few hours after a single dose, but it usually takes 3-4 weeks of regular twice daily dosing for the full effects of Ranolazine to appear.Absorption
Ranolazine is rapidly absorbed after oral administration, with peak concentrations occurring in 1-2 hours.Route of Elimination
Ranolazine is excreted primarily in the urine as unchanged drug and as its metabolites.Dosage
The typical dose of Ranolazine is 500 mg taken twice daily. The dose may be adjusted by your doctor based on your response to the medication.Administration
Ranolazine should be taken twice daily with or without food. It should be taken at the same time each day to maintain an even level of the drug in your blood.Side Effects
Common side effects of Ranolazine may include nausea, dizziness, headache, fatigue, constipation, and diarrhea.Toxicity
There is no known specific antidote for overdose with Ranolazine. Treatment should be supportive and symptomatic.Precautions
Ranolazine should not be used in patients with moderate or severe hepatic impairment.Interactions
Ranolazine should not be used in combination with other medications that reduce the oxygen levels in the heart such as ranolazine nitroglycerin and other nitrates.Disease Interactions
Ranolazine should not be used in patients with advanced kidney dysfunction or coronary artery disease.Drug Interactions
Ranolazine may interact with certain medications such as antifungals, antibiotics, HIV medications, cancer treatments, seizure medications, and heart rhythm medications.Food Interactions
Ranolazine should not be taken with high fat or high protein foods as it can affect the absorption of the drug.Pregnancy Use
Ranolazine should not be used in pregnant women unless the potential benefit outweighs the risks.Lactation Use
Ranolazine should not be used while breastfeeding as it is not known if it is safe for the infant.Acute Overdose
Overdose of ranolazine may cause nausea, vomiting, dizziness, seizures, and coma. Treatment should be supportive and symptomatic.Contraindication
Ranolazine is contraindicated in patients with moderate to severe hepatic impairment or advanced kidney dysfunction.Use Directions
Ranolazine should be taken as directed by your doctor. It is typically taken twice daily with or without food.Storage Condition
Ranolazine should be stored at room temperature away from moisture and heat.Volume of Distribution
The volume of distribution for Ranolazine is 12 L.Half Life
The half-life of Ranolazine is 8.2 hours.Clearance
Ranolazine has a clearance of 4.5 L/hr.Here you find in details version of Ranolazine
Some Frequently Asked Questions About Ranolazine
What is Ranolazine?
Ranolazine is an oral anti-anginal drug used to treat chronic angina (chest pain). It is meant to be taken in combination with other anti-anginal medications when all other treatments have failed to provide adequate relief for chest pain.
Who should take Ranolazine?
Ranolazine is approved for use in adults with chronic angina who are taking other anti-anginal medications. Your doctor will assess your medical history and any other medications you are taking before prescribing Ranolazine.
How do I take Ranolazine?
Ranolazine is usually taken twice daily with or without food. Do not change your dose or stop taking Ranolazine without consulting your doctor. If you miss a dose, take it as soon as you remember. Do not double your dose.
What are the side effects of Ranolazine?
Common side effects of Ranolazine include nausea, dizziness, headache, constipation, diarrhea, and fatigue. More serious side effects may include an irregular heartbeat, low blood pressure, and allergic reactions. If you experience any side effects, contact your doctor immediately.
What should I avoid while taking Ranolazine?
You should avoid drinking alcohol while taking Ranolazine as it can increase the risk of side effects. You should also avoid driving or operating machinery until you know how Ranolazine affects you. Do not take any other anti-anginal medications while taking Ranolazine without consulting your doctor.
What should I tell my doctor before taking Ranolazine?
Tell your doctor about any other medications you are taking, including over-the-counter medications, supplements, and herbal remedies. Inform your doctor if you have any allergies, kidney or liver disease, or heart problems. Also, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking Ranolazine.
Is Ranolazine a controlled substance?
No, Ranolazine is not a controlled substance.
How does Ranolazine work?
Ranolazine works by improving the flow of oxygen-rich blood to the heart. It interferes with the normal cycle of fat metabolism in cells, which allows more energy to reach the heart muscles during strenuous activity. This increased energy helps reduce chest pains.
What should I do if I overdose on Ranolazine?
If you think you have overdosed on Ranolazine, contact your local poison control center or emergency room immediately. Symptoms of an overdose include confusion, dizziness, fainting, and an irregular heartbeat.
How long does it take for Ranolazine to work?
The effects of Ranolazine may be felt relatively quickly but it may take up to 8 weeks before the full effects can be experienced. It's important to take Ranolazine as prescribed and to continue taking it to get the most benefit.
What other medications may interact with Ranolazine?
Certain medications may interact with Ranolazine, including certain antibiotics, HIV medications, cholesterol-lowering medications, seizure medications, and medications for heart arrhythmia. Before taking Ranolazine, make sure to inform your doctor of any other medications you are taking.
Is Ranolazine available in generic form?
No, Ranolazine is not available in generic form.
Can I take Ranolazine while pregnant or breastfeeding?
No, Ranolazine is not recommended for use in pregnant or breastfeeding women as it may cause harm to the developing baby. Consult your doctor before taking Ranolazine if you are pregnant or breastfeeding.
Can I take Ranolazine with other medications for angina?
Ranolazine is meant to be taken in combination with other anti-anginal medications, so it is safe to take with other medications for angina. Be sure to inform your doctor of all medications you are taking to ensure there are no possible interactions.
Can Ranolazine be used to treat other conditions?
No, Ranolazine is specifically approved to treat chronic angina and should not be used to treat any other condition. If you are experiencing symptoms of other conditions, consult your doctor to discuss other treatment options.
Does Ranolazine have any long-term effects?
Currently there is not enough data to determine whether there are any long-term effects of taking Ranolazine. It is important to take Ranolazine exactly as prescribed by your doctor and to contact your doctor if you experience any persistent side effects.
Is there a generic form of Ranolazine available?
No, Ranolazine is not available in generic form.
Can Ranolazine be taken with other medications?
Ranolazine can be taken with other medications, but you should always inform your doctor of any other medications you are taking to ensure there are no potential interactions. Ranolazine should not be taken with any other anti-anginal medications.
Is Ranolazine safe to take long-term?
Ranolazine is generally safe to take long-term, but you should inform your doctor of any side effects you experience. It is important to take Ranolazine exactly as prescribed to get the maximum benefit.
What should I do if I miss a dose of Ranolazine?
If you miss a dose, take it as soon as you remember. Do not double your dose. If you have taken an extra dose, contact your doctor right away.
What are the symptoms of angina?
Symptoms of angina include chest pain or discomfort, feeling tired or weak, shortness of breath, anxiety, or pain in the jaw, neck, back, or arms. If you are experiencing these symptoms, contact your doctor to discuss treatment options.
How long does it take to see the effects of Ranolazine?
The effects of Ranolazine may be felt relatively quickly but it may take up to 8 weeks before the full effects can be experienced. It's important to take Ranolazine as prescribed and to continue taking it to get the most benefit.
What are the possible side effects of Ranolazine?
Common side effects of Ranolazine include nausea, dizziness, headache, constipation, diarrhea, and fatigue. More serious side effects may include an irregular heartbeat, low blood pressure, and allergic reactions. If you experience any side effects, contact your doctor immediately.
Is Ranolazine habit-forming?
No, Ranolazine is not habit-forming.
Can children take Ranolazine?
No, Ranolazine is not approved for use in children.
Can I drink alcohol while taking Ranolazine?
No, you should not drink alcohol while taking Ranolazine as it can increase the risk of side effects.
Is Ranolazine safe for people with kidney or liver conditions?
Ranolazine should be used with caution in people with kidney or liver conditions as they may be more likely to experience side effects. Consult your doctor to discuss the risks and benefits of taking Ranolazine if you have any kidney or liver conditions.
Can people with heart conditions take Ranolazine?
Ranolazine should be used with caution in people with heart conditions. Consult your doctor to discuss the risks and benefits of taking Ranolazine if you have any heart conditions.
Does Ranolazine cause weight gain?
No, Ranolazine does not typically cause weight gain.
Can Ranolazine be split or crushed?
No, Ranolazine should not be split or crushed. It should be taken as whole tablet. If you have difficulty swallowing a tablet, contact your doctor to discuss other options.
Is Ranolazine covered by insurance?
It depends on your insurance plan. Contact your insurance provider to find out if Ranolazine is covered by your plan.
What is the cost of Ranolazine?
The cost of Ranolazine will depend on your insurance coverage and pharmacy. Contact your insurance provider and pharmacy to find out the cost of Ranolazine.
Can Ranolazine be taken on an empty stomach?
Yes, Ranolazine can be taken with or without food.
Can Ranolazine be taken with food?
Yes, Ranolazine can be taken with or without food.
Can Ranolazine be used to prevent chest pain?
Yes, Ranolazine can be used to reduce chest pain caused by chronic angina.
Does Ranolazine interact with any herbs or supplements?
Yes, certain herbs and supplements may interact with Ranolazine. Be sure to inform your doctor of any herbs or supplements you are taking before taking Ranolazine.
Is Ranolazine effective at reducing chest pain?
Yes, Ranolazine is effective at reducing chest pain caused by chronic angina.
Does Ranolazine cause any withdrawal symptoms?
No, Ranolazine does not cause any withdrawal symptoms.
Can I breastfeed while taking Ranolazine?
No, Ranolazine is not recommended for use in breastfeeding women as it may cause harm to the developing baby. Consult your doctor before taking Ranolazine if you are breastfeeding.