Proemend
Proemend Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Proemend is a brand name. Its generic name is Fosaprepitant.
Introduction
Proemend (brand name Emend®) is a drug approved by the US Food and Drug Administration in 2006 for treating nausea and vomiting caused by certain chemotherapy drugs.
Uses
Proemend is used in combination with other medications to reduce the severity of nausea and vomiting associated with certain types of cancer chemotherapy. It is also used to prevent nausea and vomiting after surgery.
Mechanism of Action
Proemend is a prodrug that is converted in the body to aprepitant. Aprepitant is a neurokinin-1 (NK-1) antagonist, an antiemetic drug that works by blocking the action of neurokinin-1 (NK-1), a hormone that can cause nausea and vomiting.
How Long Does it Take to Work?
Proemend begins to block the action of NK-1 immediately. The effects can usually be noticed within 1 to 3 hours after the first dose.
Absorption
Proemend is rapidly converted in the body to aprepitant. Aprepitant is then slowly and completely absorbed over several hours.
Route of Elimination
Aprepitant is mostly eliminated through the kidneys. Approximately 65% of a dose is recovered in the urine and 4% is recovered in the feces.
Dosage
The dose of fosaprepitant depends on the type of chemotherapy being used and the patient's body weight. The recommended dose is 125mg taken by mouth, one hour before chemotherapy.
Administration
Proemend should be taken with food. It should not be taken with grapefruit juice, as this can increase the amount of fosaprepitant in the body.
Side Effects
Common side effects of fosaprepitant include headache, body aches, nausea, and diarrhea. Rare but serious side effects include liver problems and allergic reactions.
Toxicity
Proemend is generally safe and well tolerated. Overdose of aprepitant can cause serious side effects including, nausea, vomiting, diarrhea, dizziness, drowsiness, confusion, and seizure.
Precautions
Proemend should be used with caution in patients with kidney disease or liver disease as the drug is primarily eliminated through the kidneys. It should also be used with caution in pregnant and breastfeeding women.
Interaction
Proemend may interact with other medications, including certain antibiotics, antifungals, and HIV medications. It should not be taken with grapefruit juice.
Drug Interactions
Proemend may interact with other medications, including antibiotics, antifungals, and HIV medications.
Food Interactions
Proemend should be taken with food. It should not be taken with grapefruit juice, as this can increase the amount of fosaprepitant in the body.
Pregnancy Use
Proemend should be used with caution in pregnant and breastfeeding women. It is not known if the drug passes into breast milk. Women who are pregnant or breastfeeding should not take fosaprepitant without consulting their doctor.
Lactation Use
It is not known if fosaprepitant passes into breast milk. Women who are breastfeeding should not take fosaprepitant without consulting their doctor.
Acute Overdose
Overdose of aprepitant can cause serious side effects including nausea, vomiting, diarrhea, dizziness, drowsiness, confusion and seizure.
Contraindications
Proemend should not be used in patients with a known hypersensitivity to aprepitant.
Use Direction
Proemend should be taken by mouth, one hour before chemotherapy. It should be taken with food, but not with grapefruit juice.
Storage Condition
Proemend should be stored at room temperature, away from moisture and heat.
Volume of Distribution
The volume of distribution for aprepitant is not known.
Half-Life
The half-life of aprepitant is approximately 32 hours.
Clearance
The clearance of aprepitant is not known.
Here you find in details version of Proemend