Probalan
Probalan Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Probalan is a brand name. Its generic name is Probenecid.
Introduction
Probalan is a medication used to prevent the formation of crystal deposits in the urinary tract, kidneys, and bladder. It works by preventing reabsorption of the uric acid in the kidneys and bladder and thereby decreasing levels of uric acid in the body. It is commonly used in combination with antibiotics such as penicillin and tetracycline to increase their effects. Probalan is also used to treat hyperuricemia (elevated uric acid levels in the blood), gout, and conditions that lead to recurrent urinary tract infections.
Uses for
Probalan is used in the treatment of hyperuricemia, gout, and recurrent urinary tract infections. It is also used to increase the effects of antibiotics such as penicillin and tetracycline.
Mechanism of Action
Probalan works by reducing the reabsorption of uric acid in the kidneys and bladder. This decreases the levels of uric acid in the body. Probalan also inhibits the action of the enzyme responsible for the breakdown of tetracycline and penicillin, which increases their effect.
How Long Does it Take to Work?
Probalan typically begins to take effect within a few hours after it is taken. It may take several days for the full effect of Probalan to be achieved.
Absorption
Probalan is well absorbed from the gastrointestinal tract and it is distributed to all tissues in the body.
Route of Elimination
Probalan is eliminated via the kidneys. Approximately 90% of the dose is eliminated in the urine.
Dosage
The usual recommended starting dose for adults with hyperuricemia or gout is 500 mg taken orally twice a day with meals. For recurrent urinary tract infections, the recommended starting dose is 500 mg four times daily. The dose may be increased up to 1000 mg twice a day, depending on the response to the medication.
Administration
Probalan should be taken orally with meals. It should be taken at the same time each day as directed by your doctor.
Side Effects
Common side effects of Probalan include nausea, vomiting, diuretic effects, and headache. Other side effects include fever, rash, and itching. More serious side effects are rare but may include severe allergic reaction, anemia, and renal failure.
Toxicity
Probalan is considered to be of low toxicity. Overdose may cause an elevated risk of adverse effects such as nausea, headache, and dizziness.
Pre cation
Probalan should be used with caution in patients with renal impairment, liver disease, and a history of gout or hyperuricemia. It should not be used in patients with an allergy to any of the components of the medication. It should also not be used in pregnant or breastfeeding women.
Interaction
Probalan may interact with other medications such as antibiotics, sulfonamides, salicylates, NSAIDs, and diuretics. It is important to tell your doctor about all medications you are taking before starting Probalan.
Disease Interaction
Probalan should be used with caution in patients with renal impairment, liver disease, and a history of gout or hyperuricemia.
Drug Interaction
Probalan may interact with other medications such as antibiotics, sulfonamides, salicylates, NSAIDs, and diuretics. It is important to tell your doctor about all medications you are taking before starting Probalan.
Food Interactions
Food does not significantly affect the absorption of Probalan, but it should be taken with food to reduce the risk of side effects.
Pregnancy Use
Probalan should not be used during pregnancy unless it is absolutely necessary. Women who are pregnant or breastfeeding should consult their doctor before taking Probalan.
Lactation Use
Probalan should not be used while breastfeeding. Women who are breastfeeding should talk to their doctor before starting Probalan.
Acute Overdose
Overdose of Probalan can lead to nausea, vomiting, and dizziness. If you think you have overdosed on Probalan, seek emergency medical attention immediately.
Contraindication
Probalan should not be used in patients with an allergy to any of the components of the medication, as well as patients with renal impairment, liver disease, and a history of gout or hyperuricemia.
Use Direction
Probalan should be taken orally with meals. It should be taken at the same time each day as directed by your doctor. Do not take more or less Probalan than prescribed.
Storage Condition
Probalan should be stored at room temperature, away from direct light. It should be kept in a secure location where it is inaccessible to children or pets.
Volume of Distribution
The volume of distribution of Probalan is 0.21 to 0.83 L/kg.
Half Life
The half life of Probalan is 4 to 5 hours.
Clearance
The clearance of Probalan is 0.31 to 0.44 L/h/kg.
Here you find in details version of Probalan