Pristil

Pristil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pristil is a brand name. Its generic name is Ulipristal.

Pristil Introduction

Pristil acetate is an oral medication for the treatment of uterine fibroids. It works by blocking the effects of progesterone, which helps to shrink the fibroids and reduce their size. It is the only approved non-surgical option for women who suffer from uterine fibroids. It is approved for use in women who are not suitable for surgery and is available in two strengths: 10 mg and 30 mg.

Uses For Pristil

Pristil is used for the treatment of uterine fibroids in women who are not suitable for surgery. It is to be used as part of a comprehensive treatment plan that may include lifestyle changes and other forms of treatment. Pristil helps reduce the size of uterine fibroids by blocking the effects of progesterone, the hormone responsible for the growth and function of the uterine fibroids.

Mechanism Of Action

Pristil works by targeting the progesterone receptors in the uterus and stopping the effects of progesterone on the fibroids. This results in the shrinking of the fibroids and a reduction in their size. In addition, Pristil has been found to increase the effectiveness of other treatments for fibroids, such as gonadotropin releasing hormone (GnRH) agonists.

How Long Does It Take To Work?

Pristil usually takes several months to shrink and reduce the size of uterine fibroids. It is not a rapid treatment but its long-term effects can provide relief for up to a year or longer.

Absorption

Pristil is rapidly and completely absorbed from the gastrointestinal tract following oral administration. It generally reaches maximum concentrations (Cmax) 1 to 4 hours after administration.

Route Of Elimination

Pristil is mainly eliminated by the kidneys, with a small amount also being metabolized in the liver. It has an elimination half-life of 11 hours.

Dosage

The recommended dosage for Pristil is 10 mg to 30 mg once daily for up to three months. It should be taken with food in the morning. The 10 mg dose is recommended for women who are less than 70 kg (154 lb) in weight, while the 30 mg dose is recommended for women who are more than 70 kg (154 lb) in weight.

Administration

Pristil should be taken by mouth, with food, preferably in the morning. It is important to take it regularly and as prescribed, in order to get the most benefit out of the treatment.

Side Effect

The most common side effects of Pristil include abdominal pain, headache,hot flushes or night sweats, acne, nausea, breast pain, and fatigue. Other less common side effects include depression, irregular bleeding, anxiety, and blurred vision.

Toxicity

Pristil has not been linked to any direct or serious toxicity in humans. However, it is important to follow the instructions of your healthcare provider when taking Pristil.

Precaution

Pristil should not be used in women who are pregnant or breastfeeding. It should also not be used in women with severe liver impairment or who have difficulty swallowing. Additionally, women should inform their doctor if they are taking any other medications, as certain drugs can interact with Pristil.

Interaction

Pristil interacts with some medications, including estrogen-containing contraceptive drugs, glucocorticoids, and immunosuppressant drugs. It is important to inform your doctor of all medications you are taking when taking Pristil.

Disease Interaction

Pristil acetate can interact with certain diseases. People with severe liver impairment or those with difficulty swallowing should not take Pristil. It is also not advised to use in women with a history of stroke or blood clot.

Drug Interaction

Pristil acetate can interact with certain drugs as it can reduce the effectiveness of certain medications or increase the risk of certain side effects. As such, it is important to inform your doctor of all medications you are taking before starting Pristil.

Food Interactions

Pristil should be taken with food. It is also important to note that it should not be taken with grapefruit juice as this can increase the risk of certain side effects. It is also important to avoid alcohol when taking Pristil.

Pregnancy Use

Pristil is not recommended for use during pregnancy as it can affect the normal development of the fetus. Women who are pregnant or breastfeeding should not take Pristil.

Lactation Use

Pristil is not recommended for use during lactation as it can be passed into breast milk and can affect the baby. Women who are breastfeeding should not take Pristil.

Acute Overdose

An acute overdose of Pristil is unlikely to produce serious toxicity due to its low toxicity profile. Treatment should include close monitoring and supportive care.

Contraindication

Pristil is contraindicated in women who are pregnant, breastfeeding, or have severe liver impairment. It should also not be used in women who are taking certain medications or have a history of stroke or blood clot.

Use Direction

Pristil should be taken as directed by your doctor. The recommended dosage is 10 mg to 30 mg once daily for up to three months, with food in the morning. It is important to take this medication as directed to get the most benefit from the treatment.

Storage Condition

Pristil should be stored at room temperature, in a dry place, and away from light.

Volume Of Distribution

Pristil has a volume of distribution of approximately 329 L.

Half Life

The half-life of Pristil is approximately 11 hours.

Clearance

The clearance rate of Pristil is approximately 3.8 L/hr/kg.

Here you find in details version of Pristil

Some Frequently Asked Questions About Pristil

What is Pristil?

Pristil is a prescription medication used to treat certain types of abnormal bleeding of the uterus and to treat fibroids (noncancerous tumors) of the uterus.

How does Pristil work?

Pristil works by blocking the effects of progesterone, a hormone that helps cause certain abnormal uterine bleeding. It also helps reduce the size of fibroids.

What is Pristil used to treat?

Pristil is used to treat abnormal uterine bleeding due to hormonal imbalance and to treat uterine fibroids.

What are the side effects of Pristil?

Common side effects of Pristil include headache, nausea, abdominal pain, vomiting, diarrhea, and menstrual cramps.

Is Pristil safe to use?

Yes, Pristil is generally considered safe to use when taken as directed.

How long does it take for Pristil to start working?

Pristil usually starts working within a few days of taking it.

How often should I take Pristil?

Pristil should be taken once daily as prescribed by your doctor.

Can I take Pristil while pregnant?

No, Pristil is not recommended for use in pregnant women.

What should I do if I miss a dose of Pristil?

If you miss a dose of Pristil, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next scheduled dose.

Can I take Pristil with other medications?

You should always ask your doctor or pharmacist before taking any other medications with Pristil, including over-the-counter medications, vitamins, and supplements.

What is the most common reason for taking Pristil?

The most common reason for taking Pristil is to treat abnormal uterine bleeding due to hormonal imbalance, and to treat uterine fibroids.

What should I do if I experience side effects from Pristil?

If you experience any side effects from Pristil, talk to your doctor or pharmacist right away. They may recommend changes or advise you to stop taking Pristil.

Can Pristil be used for emergency contraception?

No, Pristil is not intended for use as emergency contraception.

Can I drink alcohol while taking Pristil?

It is not recommended to drink alcohol while taking Pristil as it can increase the risk of side effects such as nausea and vomiting.

Can Pristil cause weight gain?

Weight gain is not a common side effect of Pristil. If you experience any sudden or unexpected weight gain, talk to your doctor.

Does Pristil interact with any other medications?

Yes, Pristil can interact with certain medications, such as antifungal medications and antibiotics. Always check with your doctor or pharmacist before taking any other medications with Pristil.

Is Pristil available over-the-counter?

No, Pristil is a prescription medication and is not available over-the-counter.

What happens if I overdose on Pristil?

If you think you have overdosed on Pristil, seek immediate medical attention or call your local poison control center.

Can Pristil be used to treat endometriosis?

Pristil may be used in some cases to treat endometriosis. However, more research is needed to confirm its effectiveness in treating this condition.

Is Pristil safe for long-term use?

Pristil is generally considered safe for long-term use when taken as directed. Talk to your doctor if you have any questions about long-term use of this medication.

How long does Pristil stay in your system?

Pristil has a half-life of about 37 hours and can stay in your system for up to 79 hours.

Is Pristil a hormonal medication?

Yes, Pristil is a hormonal medication, specifically an antagonist of progesterone (a hormone that helps cause certain abnormal uterine bleeding).

Can Pristil be used to treat acne?

No, Pristil is not indicated for the treatment of acne.

Can Pristil be used to treat ovarian cysts?

Pristil may be used to treat some cases of ovarian cysts, but more research is needed to confirm its effectiveness in treating this condition.

Can Pristil be used to treat polycystic ovary syndrome (PCOS)?

Pristil may be effective in some cases to treat the symptoms of PCOS, but more research is needed to confirm its effectiveness in treating this condition.

How quickly does Pristil take effect?

Pristil usually takes effect within a few days of taking it.

Can Pristil cause mood swings?

Mood swings are not a common side effect of Pristil, but it is possible that taking the medication could affect your mood. If you experience any changes in your mood while taking Pristil, talk to your doctor.

How is Pristil taken?

Pristil is taken orally once daily as prescribed by your doctor.

Does Pristil cause nausea?

Nausea is a common side effect of Pristil, so if you experience any nausea while taking the medication, talk to your doctor.

Can Pristil cause breast tenderness?

Yes, breast tenderness is a common side effect of Pristil.

Does Pristil interact with birth control?

Yes, Pristil may interact with some types of birth control and can affect their effectiveness. Always talk to your doctor or pharmacist before taking any other medications with Pristil.

Does Pristil cause weight loss?

Weight loss is not a common side effect of Pristil. However, if you experience any sudden or unexpected weight loss while taking Pristil, talk to your doctor.

Can Pristil cause fatigue?

Fatigue is not a common side effect of Pristil, but it is possible that taking the medication could cause fatigue or tiredness. If this occurs, talk to your doctor.

Can Pristil affect your menstrual cycle?

Yes, Pristil can affect your menstrual cycle, as it blocks the effects of progesterone, a hormone that helps cause certain abnormal uterine bleeding.

Does Pristil cause birth defects?

Pristil is not known to cause birth defects. However, it should not be used during pregnancy as it could have an effect on the fetus.

Can Pristil be used to treat hot flashes?

Pristil is not indicated for the treatment of hot flashes.

Does Pristil cause hair loss?

Hair loss is not a common side effect of Pristil, but it is possible that taking the medication could cause hair loss. If this occurs, talk to your doctor.

Can Pristil cause headaches?

Yes, headaches are a common side effect of Pristil.

Does Pristil affect fertility?

Pristil may affect fertility in some cases, but more research is needed to determine its effect on fertility.

Can Pristil cause an increased appetite?

Increased appetite is not a common side effect of Pristil, but it is possible that taking the medication could cause an increase in appetite. If this occurs, talk to your doctor.