Pregnyl

Pregnyl Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pregnyl is a brand name. Its generic name is Human Chorionic Gonadotrophin.

Introduction

Human Chorionic Gonadotropin (hCG) is a hormone produced by the placenta during pregnancy and has been used for decades as a fertility medication. It works by stimulating the ovaries to produce multiple eggs in one cycle.

Uses of hCG

hCG is used as a fertility drug to treat infertility in both men and women. For women, it is used to induce ovulation in order to achieve pregnancy. In men, it is used to increase sperm count and improve semen quality. It is also used in conjunction with other fertility drugs to increase the chances of pregnancy in women undergoing in vitro fertilization (IVF).

Mechanism of action

hCG works by stimulating the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland. These hormones travel to the ovaries and stimulate the production of multiple eggs in one cycle. This increases the chances of fertilization and successful pregnancy.

How long does it take to work?

On average, hCG takes effect 7 to 10 days after it is administered. It is important that the user follows the instructions provided by their doctor and takes the medication as prescribed.

Absorption

hCG is absorbed through the digestive tract and quickly enters the bloodstream.

Route of Elimination

hCG is eliminated through the kidneys in the urine.

Dosage

The dosage of hCG for treating fertility issues depends on the patient, the diagnosis, and the prescription issued by the doctor. It is usually given as an injection or as a capsule. Injections are usually given one to three times per day and can be intramuscular, subcutaneous or intravenous. Capsules are taken orally, usually three times per day.

Administration

hCG can be administered as an injection or in pill form. Injections are typically intramuscular, subcutaneous or intravenous and are given one to three times per day. Capsules are taken orally, usually three times per day.

Side Effects

Common side effects associated with hCG use include headache, depression, irritability, shortness of breath, breast tenderness, abdominal pain, and nausea. Serious side effects include blood clots, pulmonary edema, and allergic reactions.

Toxicity

Toxicity associated with hCG use is rare and usually occurs with prolonged or excessive use. Symptoms of toxicity include headaches, fatigue, insomnia, and depression.

Precaution

Patients taking hCG should inform their doctor of any current or past medical conditions, especially cancer. Patients should be aware of the potential risks associated with the medication and contact their healthcare provider if any side effects occur.

Interaction

hCG should not be taken with certain medications, such as anticoagulants, steroids, or cyclosporine. Patients should avoid drinking alcohol while taking hCG and should not take any other medications without consulting their doctor first.

Disease Interaction

hCG should not be used by patients with certain medical conditions, such as liver disease, kidney disease, or prostate cancer. hCG increases the risk of blood clots and can worsen some medical conditions. Patients should inform their doctor of any medical conditions before starting hCG.

Drug Interaction

hCG should not be taken with certain medications, such as anticoagulants, steroids, or cyclosporine. Patients should avoid drinking alcohol while taking hCG and should not take any other medications without consulting their doctor first.

Food Interactions

hCG should be taken with food to reduce stomach upset. Dietary restrictions are not necessary, but alcohol should be avoided.

Pregnancy Use

hCG is FDA-approved for the treatment of infertility in both men and women. However, it is not recommended for women who are pregnant. Women who are pregnant should inform their doctor before taking hCG.

Lactation Use

hCG is not recommended for women who are breastfeeding.

Acute Overdose

Acute overdose of hCG is rare. In the case of an overdose, contact a poison control center immediately.

Contraindication

hCG should not be used by patients with certain medical conditions, such as liver disease, kidney disease, or prostate cancer. hCG increases the risk of blood clots and can worsen some medical conditions. Patients should inform their doctor of any medical conditions before starting hCG.

Use Direction

hCG should be taken as prescribed by the doctor. Typically, hCG is given as an injection or as a capsule. Injections are usually given one to three times per day and can be intramuscular, subcutaneous or intravenous. Capsules are taken orally, usually three times per day.

Storage Condition

hCG should be stored at room temperature and away from direct sunlight. It is recommended that hCG be refrigerated if not used within two weeks.

Volume of Distribution

The volume of distribution of hCG is approximately 5L/kg.

Half-life

The half-life of hCG is 24 to 36 hours.

Clearance

Clearance of hCG occurs primarily in the liver.

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