Prednisona

Prednisona Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Prednisona is a brand name. Its generic name is Prednisone.

Introduction

Prednisona is a prescription corticosteroid medication used to treat a wide range of conditions. It is a synthetic agent that mimics glucocorticoids, which are naturally produced by the body. Prednisona alters the body’s immune response and has a powerful anti-inflammatory action. It is most often used to treat inflammation and pain associated with certain autoimmune and rheumatic (i.e joint related) diseases.

Uses For

Prednisona is prescribed to treat conditions such as:

• Arthritis
• Asthma
• Allergic reactions
• Skin disorders, such as eczema
• Kidney disease
• Cancer
• Multiple sclerosis
• Intestinal disorders
• Glandular disorders

Mechanism of Action

Prednisona works by suppressing the body's immune system, reducing inflammation and suppressing the body’s ability to produce certain proteins that are involved in the immune response. By reducing the activity of the immune system, prednisone can help reduce inflammation and prevent tissue damage due to autoimmune and rheumatoid diseases. Additionally, prednisone works by altering the behavior of certain cells that are involved in the immune response. It decreases the production of substances that cause inflammation and constricts the airways.

How Long Does it Take to Work

The effects of prednisone vary depending on the dose and duration of treatment. Prednisona can start to take effect within hours of taking it and its effects can last for days or weeks depending on the dose. Generally, oral prednisone takes effect within 2-4 hours and its peak effects will be seen within 8-12 hours.

Absorption

Prednisona is rapidly absorbed from the gastrointestinal tract and reaches peak blood concentrations 1-2 hours after administration. It is highly protein-bound and has a large volume of distribution.

Route of Elimination

Prednisona is primarily eliminated by the kidneys. It is slowly released from cells and metabolites are cleared from the body. The half-life of prednisone ranges from 2-4 hours.

Dosage

The dosage of prednisone depends on the condition being treated and should be taken according to the prescriber’s instructions. The usual adult dose for treating inflammation and pain is between 5-60mg daily in the form of tablets or an oral syrup. For treating rheumatoid arthritis, the usual dosage is 5-10mg once daily or intermittently as directed by the prescriber. For Asthma, the usual dosage is 5-60mg daily for up to 10 days.

Administration

Prednisona should be taken either orally or via an injection. Depending on the condition being treated, it may be taken in the form of tablets, capsules, syrup, an oral suspension or via intramuscular injection. If taking prednisone orally, it should be taken with food or a full glass of water.

Side Effects

Common side effects of prednisone include:

• Nausea and vomiting
• Anxiety
• Fluid retention
• Headache
• Insomnia
• Weight gain
• Increased risk of infections
• High blood pressure
• Changes in vision

Toxicity

Long-term use of prednisone can cause serious side effects, including osteoporosis, glaucoma, cataracts, diabetes, high blood pressure, and an increased risk of infection. Prednisona should not be used in pregnancy or lactation.

Precautions

Patients taking prednisone should be monitored for any signs of side effects. Prednisona should not be taken with any other medication, unless instructed by a doctor, as it can interact with other drugs. It should not be taken for prolonged periods of time and if it is, the patient should be monitored for any signs of adverse effects.

Interaction

Prednisona can interact with certain medications, such as aspirin, antacids, digoxin, diuretics, warfarin, phenytoin, and certain antibiotics. When taking prednisone, it is important to check with a doctor or pharmacist to see if any other medications can interact with prednisone.

Disease Interaction

Patients taking prednisone should be monitored for any signs of adverse effects or medical complications. Prednisona use has been associated with an increased risk of infection, so patients should be monitored closely for any signs of infection. Patients with pre-existing infections should not use prednisone.

Drug Interaction

Prednisona can interact with many other medications and should not be taken with any other medication, unless instructed by a doctor. Prednisona can interact with antacids, aspirin, diuretics, warfarin, phenytoin, and certain antibiotics. It can also increase the risk of side effects with certain medications, including antidepressants, seizure medications, and antifungal medications.

Food Interactions

Prednisona should not be taken with certain foods, such as grapefruit juice, alcohol, and vitamin C. Prednisona may also affect the body’s absorption of dietary calcium, so it is important to monitor calcium intake when taking prednisone.

Pregnancy Use

Prednisona should not be taken during pregnancy as it can have adverse effects on the fetus. It should only be used when the potential benefit justifies the potential risk to the fetus.

Lactation Use

Prednisona is excreted in breast milk and should not be taken while breastfeeding.

Acute Overdose

Signs and symptoms of a prednisone overdose may include nausea, vomiting, diarrhea, stomach pain, confusion, dizziness, headache, fainting, seizures, and coma. If an overdose is suspected, contact your doctor or local poison control center immediately.

Contraindication

Prednisona may not be suitable for people with certain medical conditions. People with a history of liver or kidney disease, a weakened immune system, or mental disorders should not take prednisone.

Use Directions

Prednisona should be taken as prescribed by the doctor. It is important to follow the directions exactly. Do not take more or less than prescribed and never stop taking it without consulting a doctor. Prednisona should be taken with food or a full glass of water.

Storage Condition

Prednisona should be stored at room temperature, away from heat and light. Keep the medication out of the reach of children and pets and discard any expired medication.

Volume of Distribution

The volume of distribution of prednisone is 5-10 liters/kg.

Half-Life

The half-life of prednisone ranges from 2-4 hours.

Clearance

Prednisona is primarily cleared by the kidneys. Metabolites of prednisone are slowly cleared from the body.

Here you find in details version of Prednisona

Some Frequently Asked Questions About Prednisona

What is Prednisona?

Prednisona is a corticosteroid drug used to treat a wide range of inflammatory, allergic, and immune conditions such as asthma, Crohn's disease, and multiple sclerosis.

What are the side effects of Prednisona?

Common side effects of Prednisona include headache, nausea, vomiting, stomach upset, heartburn, dizziness, acne, increased sweating, trouble sleeping, and changes in the shape or location of body fat.

Is Prednisona a steroid?

Yes, Prednisona is a type of steroid medication.

How long does it take for Prednisona to start working?

The effects of Prednisona can vary depending on the condition being treated. In general, Prednisona begins to work within a few hours to a few days.

What is the difference between Prednisona and Prednisolone?

Prednisona and Prednisolone are both corticosteroid drugs. The difference is that Prednisona is converted to Prednisolone in the liver, so Prednisolone has a more direct effect on the body.

How long does it take for Prednisona to get out of your system?

For most people, it takes about three days for Prednisona to completely leave your system. The exact length of time can depend upon the dose and amount of time it was taken.

What are the side effects of long-term use of Prednisona?

Long-term use of Prednisona can cause a range of side effects, including weight gain, high blood pressure, reduced bone density, increased risk for infection, and increased risk of digestive problems.

Is Prednisona addictive?

No, Prednisona is not addictive.

Can I drink alcohol while taking Prednisona?

It is not recommended to drink alcohol while taking Prednisona. Alcohol can increase the risk of certain side effects and can interact with Prednisona.

What is the maximum dosage of Prednisona that can be taken?

The maximum dose of Prednisona will vary depending on the condition being treated. It is important to follow the instructions of your health care provider when taking Prednisona.

Is Prednisona safe for pregnant women?

The use of Prednisona during pregnancy should be closely monitored by a health care provider. It is generally not advised for pregnant women to take any medications without consulting their doctor first.

Can Prednisona put my body into "shock"?

Prednisona can cause an overactive immune response, which can lead to a severe reaction called anaphylaxis, but it is unlikely to cause shock.

What should I do if I forget to take a dose of Prednisona?

If you forget to take a dose of Prednisona, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with your normal schedule.

Should I take Prednisona with food?

Yes, it is generally recommended to take Prednisona with food. Taking Prednisona with food can help to reduce stomach upset and keep the medication from being released too quickly into the bloodstream.

Can Prednisona cause hair loss?

Yes, long-term use of Prednisona can cause hair loss in some people. If you experience hair loss while taking Prednisona, be sure to talk to your doctor about potential treatments.

Can Prednisona affect my blood sugar levels?

Yes, Prednisona can raise blood sugar levels, especially in people with pre-existing diabetes. It is important to monitor your blood sugar levels closely when taking Prednisona.

How can I reduce side effects from Prednisona?

Many of the side effects of Prednisona can be reduced by eating a healthy diet and avoiding alcohol. It is also important to practice good sleep hygiene and limit your caffeine intake.

Are there any natural alternatives to Prednisona?

There are some natural remedies that may be effective in treating inflammation and other symptoms that are treated with Prednisona. Examples include turmeric, ginger, omega-3 fatty acids, and probiotics.

Can Prednisona cause weight gain?

Yes, Prednisona can cause weight gain due to its effect on the body's metabolism and appetite. It is important to maintain a healthy diet and an active lifestyle to help reduce potential weight gain.

Can Prednisona cause mood swings or anxiety?

Yes, Prednisona can cause mood swings and anxiety due to its effect on the body's hormones. It is important to talk to your doctor if you have any concerns about your mood or anxiety.

Can I take ibuprofen while taking Prednisona?

No, ibuprofen should not be taken while taking Prednisona. Ibuprofen can interact with Prednisona and increase the risk of certain side effects.

Can Prednisona cause liver damage?

Prednisona has been known to cause liver damage, though this is rare. It is important to discuss any potential risk to your liver with your health care provider before taking Prednisona.

How long does it take Prednisona to work for asthma?

The effects of Prednisona can vary depending on the severity of the asthma attack. Generally, it should begin to work within a few hours to a few days.

What is the difference between Prednisona and prednisolone?

The difference between Prednisona and prednisolone is that Prednisona is converted to prednisolone in the liver, so prednisolone has a more direct effect on the body.

Does Prednisona affect blood pressure?

Yes, Prednisona can raise blood pressure by increasing salt and water retention. It is important to monitor your blood pressure regularly if you are taking Prednisona.

Can Prednisona cause vision problems?

Yes, long-term use of Prednisona can cause vision problems, such as cataracts and glaucoma. It is important to discuss any vision changes with your health care provider.

Is it safe to exercise while taking Prednisona?

Yes, exercise can be beneficial while taking Prednisona. However, it is important to talk to your doctor first to make sure that the type and intensity of exercise is appropriate for your condition.

Can Prednisona cause stomach ulcers?

Yes, Prednisona can cause stomach ulcers due to its effect on the lining of the stomach. If you have stomach pain, it is important to talk to your doctor.

Can I take other medications while taking Prednisona?

It is important to talk to your doctor before taking any other medications while taking Prednisona. Some medications can interact with Prednisona and increase the risk of side effects.

Can Prednisona cause muscle weakness?

Yes, long-term use of Prednisona can cause muscle weakness due to its effect on hormones and protein metabolism. If you are experiencing muscle weakness, it is important to talk to your doctor.

Can Prednisona cause depression?

Yes, Prednisona can cause depression due to its effect on hormones and neurotransmitter levels. If you experience depression, it is important to talk to your doctor about potential treatments.

Can I take allergy medicine while taking Prednisona?

No, it is not recommended to take any other medications, including allergy medications, while taking Prednisona. Certain medications can interact with Prednisona and increase the risk of side effects.

Can I take aspirin while taking Prednisona?

No, aspirin should not be taken while taking Prednisona. Aspirin can interact with Prednisona and increase the risk of certain side effects.

How can I reduce the side effects of Prednisona?

Many of the side effects of Prednisona can be reduced by eating a healthy diet and avoiding alcohol. It is also important to practice good sleep hygiene and limit your caffeine intake.

Can Prednisona worsen existing conditions?

Yes, Prednisona can exacerbate or worsen certain existing conditions. It is important to discuss your medical history with your doctor before taking Prednisona.

Can Prednisona be used to treat autoimmune diseases?

Yes, Prednisona can be used to treat a wide range of autoimmune diseases, such as lupus, rheumatoid arthritis, and multiple sclerosis.

Can Prednisona be used to treat cancer?

Yes, Prednisona can be used to treat some types of cancer, as well as some lymphomas and leukemias.

Can Prednisona cause skin irritation?

Yes, Prednisona can cause skin irritation due to its effect on hormones and the immune system. If you experience skin irritation, it is important to talk to your doctor.

Can Prednisona cause kidney damage?

Yes, Prednisona can cause kidney damage, though this is rare. It is important to discuss any potential risk for kidney damage with your health care provider before taking Prednisona.

What happens if I miss a dose of Prednisona?

If you miss a dose of Prednisona, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with your normal schedule.

Is Prednisona safe for children?

Yes, Prednisona can be safely used in children. However, it is important to follow the instructions of your health care provider for the correct dosage and frequency.

Can Prednisona be used to treat infections?

Yes, Prednisona can be used to treat certain bacterial and viral infections, as well as autoimmune conditions that cause inflammation or weaken the immune system.