Pradaxa
Pradaxa Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pradaxa is a brand name. Its generic name is Dabigatran etexilate.
Introduction
Pradaxa is an anticoagulant and works by inhibiting thrombin. It is prescribed for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation, the prevention of deep vein thrombosis and pulmonary embolism following hip or knee replacement surgery, and for the treatment of deep vein thrombosis and pulmonary embolism.Uses
Pradaxa is used to reduce the risk of stroke and systemic embolism in people with non-valvular atrial fibrillation (AF). It also prevents deep vein thrombosis and pulmonary embolism following hip or knee replacement surgery, and treats existing deep vein thrombosis and pulmonary embolism.Mechanism of Action
Pradaxa is a direct thrombin inhibitor, meaning it works by blocking the action of thrombin, an enzyme in the clotting process. By blocking the action of thrombin, Pradaxa prevents clot formation and reduces the risk of stroke and systemic embolism.How Long Does It Take to Work?
Pradaxa usually begins to work within 10 minutes after being taken orally.Absorption
Pradaxa is rapidly and nearly completely absorbed once taken orally.Route of Elimination
Pradaxa is largely eliminated unchanged from the body via biliary excretion.Dosage
The recommended oral dosage of dabigatran etexilate is 150 mg twice daily without food or with light food. For patients with severe renal dysfunction, the recommended dosage is 75 mg twice daily.Administration
Pradaxa should be taken with or without food, but it should not be taken with food containing a high fat content. The tablets should be swallowed with a full glass of water, and should not be crushed, split or chewed.Side Effect
Common side effects of dabigatran etexilate include nausea, diarrhea, dyspepsia, abdominal pain, gas and headache.Toxicity
Pradaxa is a well-tolerated drug with few serious or long-term effects. The most serious side effect is bleeding, especially in patients with severe renal dysfunction.Precaution
Patients taking dabigatran etexilate should be monitored for signs of bleeding, as the drug can increase the risk of serious bleeding. The drug should not be used in patients with severe renal impairment or in patients who have hypersensitivity to any of the excipients.Interaction
Pradaxa can interact with other medications, such as antacids, drugs that inhibit CYP3A4, and drugs that induce CYP3A4.Disease Interaction
Pradaxa can interact with certain diseases, such as renal impairment, hypomagnesaelmia, and hepatic impairment.Drug Interaction
Pradaxa can interact with other drugs, such as antacids, antibiotics, antiretrovirals, glucocorticoids, and proton pump inhibitors.Food Interactions
Pradaxa may interact with certain food products. Patients taking the drug should avoid consuming high-fat meals, and should not take the drug with food containing high fat content.Pregnancy Use
Pradaxa should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.Lactation Use
Pradaxa should not be used during breastfeeding unless the potential benefit justifies the potential risk to the infant.Acute Overdose
Patients who overdose on dabigatran etexilate may experience bleeding complications, including gastrointestinal bleeding, hematuria, or hematemesis. Treatment for an overdose of dabigatran etexilate may include the administration of antidote therapies and supportive care measures.Contraindication
Pradaxa is contraindicated in patients with severe renal impairment, and in patients who have hypersensitivity to any of the excipients.Use Direction
Pradaxa should be taken orally, usually once or twice daily depending on the patient's situation. The tablets should be taken with a full glass of water, and should not be crushed, split or chewed.Storage Condition
Pradaxa tablets should be stored in the closed container at room temperature (15–30°C). Avoid exposing this medicine to direct sunlight, temperature extremes (especially over 25°C), or humidity.Volume of Distribution
The volume of distribution of dabigatran etexilate is 44–54 L.Half Life
The half-life of dabigatran etexilate is 12-17 hours.Clearance
The clearance of dabigatran etexilate is 5.9 L/h.Here you find in details version of Pradaxa
Some Frequently Asked Questions About Pradaxa
Q1. What is Pradaxa?
A: Pradaxa is an anticoagulant medication used to prevent blood clots. It is taken to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AFib).
Q2. Who should not take dabigatran etexilate?
A: People who are allergic to dabigatran or any of its ingredients should not take dabigatran etexilate. People with certain conditions, such as severe kidney impairment and active bleeding, should not take dabigatran etexilate.
Q3. How does dabigatran etexilate work?
A: Pradaxa belongs to a class of drugs called direct thrombin inhibitors. It works by blocking the formation of enzymes, called thrombin, that cause the formation of blood clots.
Q4. What are the possible side effects of dabigatran etexilate?
A: Common side effects of dabigatran etexilate include nausea, heartburn, diarrhea, and muscle pain. Rare but serious side effects may include an increased risk of bleeding, which can be life-threatening.
Q5. Does dabigatran etexilate interact with other medications?
A: Pradaxa may interact with certain antibiotics, antifungals, and medications used to treat high blood pressure and heart failure. Make sure to tell your healthcare provider about all the medicines you take before taking dabigatran etexilate.
Q6. Is dabigatran etexilate safe for long term use?
A: Pradaxa is generally safe for long term use in appropriate doses. It is important to note that dabigatran etexilate may interact with other medications, so it is important to take it exactly as prescribed by your doctor.
Q7. Can I take dabigatran etexilate while pregnant?
A: Pradaxa has not been studied in pregnant women, so it is not recommended for use during pregnancy. If you are pregnant or plan to become pregnant, talk to your doctor about the potential risks and benefits of taking dabigatran etexilate.
Q8. Is dabigatran etexilate available over the counter?
A: Pradaxa is not available over the counter. It is available by prescription only. Be sure to talk to your doctor before taking any medication.
Q9. What is the recommended dose of dabigatran etexilate?
A: The recommended dose of dabigatran etexilate is 150mg twice daily for most people. Lower doses are available for people with reduced kidney function. Please talk to your doctor about the appropriate dose for you.
Q10. Is it safe to take dabigatran etexilate with other anticoagulants?
A: It is generally not recommended to take dabigatran etexilate with other anticoagulants due to the increased risk of bleeding. Talk to your doctor before taking any medications together.
Q11. Can I take dabigatran etexilate if I have a peptic ulcer?
A: People with a peptic ulcer should avoid taking dabigatran etexilate due to the increased risk of bleeding. Talk to your doctor to discuss the best anticoagulant option for you.
Q12. What are the common signs and symptoms of bleeding while taking dabigatran etexilate?
A: Common signs and symptoms of bleeding while taking dabigatran etexilate include easy bruising, nosebleeds, and bleeding gums. It is important to seek medical attention immediately if you have any signs or symptoms of bleeding.
Q13. Is it safe to take dabigatran etexilate with acetaminophen?
A: Pradaxa and acetaminophen can be taken together, however it is important to avoid taking too much acetaminophen because it may increase the risk of bleeding. It is best to take both medications as directed by your doctor.
Q14. What should I do if I miss a dose of dabigatran etexilate?
A: If you miss a dose of dabigatran etexilate, take it as soon as possible and then take the next dose at your regular time. Do not double up on doses. Talk to your doctor if you have any concerns about missing doses.
Q15. Is dabigatran etexilate safe for people with kidney disease?
A: People with kidney disease can take dabigatran etexilate, however they may require a lower dose in order to avoid the increased risk of bleeding. Talk to your doctor to discuss the best dose for you.
Q16. What is the most common side effect of dabigatran etexilate?
A: The most common side effect of dabigatran etexilate is nausea. Other common side effects include heartburn, diarrhea, and muscle pain. Talk to your doctor if you experience any side effects while taking dabigatran etexilate.
Q17. Can I drink alcohol while taking dabigatran etexilate?
A: Drinking alcohol while taking dabigatran etexilate is not recommended due to the increased risk of bleeding. If you do choose to drink alcohol, do so in moderation.
Q18. How long does it take for dabigatran etexilate to work?
A: It typically takes 2 to 4 days for dabigatran etexilate to reach its maximum effect. Be sure to take your doses as prescribed by your doctor.
Q19. Is it safe to take dabigatran etexilate while breastfeeding?
A: Pradaxa is generally not recommended for use while breastfeeding due to the increased risk of bleeding. Talk to your doctor to discuss the potential risks and benefits of taking dabigatran etexilate while breastfeeding.
Q20. Can I take ibuprofen while taking dabigatran etexilate?
A: Ibuprofen can be taken while taking dabigatran etexilate, however it is important to take it according to the directions on the bottle and to take the lowest possible dose. Taking too much ibuprofen may increase the risk of bleeding.
Q21. What is the recommended diet and exercise regimen while taking dabigatran etexilate?
A: Eating a healthy diet that is low in fat and cholesterol and exercising regularly is recommended for people taking dabigatran etexilate. Talk to your doctor to create a diet and exercise routine that is right for you.
Q22. Can I take aspirin while taking dabigatran etexilate?
A: Aspirin should not be taken while taking dabigatran etexilate due to the increased risk of bleeding. Talk to your doctor before taking any medications together.
Q23. Is there an antidote for dabigatran etexilate?
A: Currently, there is no antidote available for dabigatran etexilate. It is important to take dabigatran etexilate according to the directions of your doctor in order to avoid serious side effects.
Q24. Can I take any dietary supplements while taking dabigatran etexilate?
A: It is best to avoid taking any dietary supplements while taking dabigatran etexilate due to the increased risk of bleeding. Talk to your doctor before taking any dietary supplements while taking dabigatran etexilate.
Q25. Is dabigatran etexilate effective in preventing stroke?
A: Pradaxa is effective in reducing the risk of stroke in patients with nonvalvular atrial fibrillation (AFib). Talk to your doctor to determine if dabigatran etexilate is right for you.
Q26. Can I drive if I am taking dabigatran etexilate?
A: It is generally safe to drive if you are taking dabigatran etexilate. It is important to be aware of the side effects of dabigatran etexilate, such as dizziness and fatigue, and be aware of any changes to your mental or physical abilities.
Q27. Does dabigatran etexilate have any effect on fertility?
A: Pradaxa has not been studied in pregnant women or men with fertility issues, so the effects of dabigatran etexilate on fertility are unknown. Talk to your doctor if you are concerned about the effects of dabigatran etexilate on fertility.
Q28. How should I store dabigatran etexilate?
A: Pradaxa should be stored at room temperature, away from light and moisture. Do not store the medication in the refrigerator or freezer. Keep all medications out of reach of children and pets.
Q29. What should I do if I experience an allergic reaction to dabigatran etexilate?
A: If you experience any signs of an allergic reaction to dabigatran etexilate, such as rash, hives, or difficulty breathing, seek medical attention immediately. Inform your doctor if you are allergic to any of the ingredients in dabigatran etexilate.
Q30. Is there an alternative to dabigatran etexilate?
A: There are other anticoagulant medications available to prevent blood clots, including warfarin and apixaban. Your doctor can help you decide which medication is best for you based on your medical history and risk factors.