Phtalazol tablets 0,5 g
Phtalazol tablets 0,5 g Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Phtalazol tablets 0,5 g is a brand name. Its generic name is Phthalylsulfathiazole.
Introduction
Phtalazol tablets 0,5 g (PST) is an antibacterial sulfonamide antibiotic. PST is used for the treatment of mild to moderate bacterial infections, including urinary tract infections, throat infections, and ear infections. It is usually prescribed in combination with other antibiotics to provide more effective bacterial treatment.
Uses
Phtalazol tablets 0,5 g is used to treat a variety of bacterial infections. It is most commonly used to treat mild to moderate urinary tract infections, throat infections, and ear infections. PST may also be prescribed to treat other bacterial infections when combined with other antibiotics.
Mechanism of Action
Phtalazol tablets 0,5 g works by inhibiting the growth of bacteria by preventing the bacteria from forming the proteins needed to replicate. PST inhibits the production of an enzyme called dihydropteroate synthase, which is responsible for producing the folic acid that is needed for DNA replication in growing bacterial cells.
How Long Does It Take to Work?
The effects of Phtalazol tablets 0,5 g can be seen within 24-48 hours of taking the antibiotic. In most cases, the bacterial infection should be resolved within seven days of starting the medication.
Absorption
Phtalazol tablets 0,5 g is absorbed well when taken orally. Over ninety percent of the medication is absorbed from the gastrointestinal tract.
Route of Elimination
The route of elimination for Phtalazol tablets 0,5 g is via the kidneys. The antibiotic is eliminated from the body via the urine.
Dosage, Administration, and Side Effects
Phtalazol tablets 0,5 g is usually administered orally in a daily dose of 160mg. The total daily dosage may be divided into smaller doses taken twice per day. Common side effects may include nausea, vomiting, upset stomach, and diarrhea.
Toxicity
The toxicity of Phtalazol tablets 0,5 g is considered to be low. The drug is generally well-tolerated with few reported side effects.
Precautions
Patients taking Phtalazol tablets 0,5 g should avoid taking Vitamin C and iron supplements, as they may interfere with the absorption of the drug. Patients should also avoid alcohol, as the combination can cause nausea and vomiting.
Interactions
Phtalazol tablets 0,5 g may interact with other medications, such as probenecid, warfarin, sulfonylureas, and cimetidine, among others. Patients taking any of these medications should speak with their doctor before taking PST.
Disease Interactions
Patients with liver disease, kidney disease, diabetes, or a history of hypersensitivity should speak with their doctor before taking PST.
Drug Interactions
Phtalazol tablets 0,5 g may interact with other medications, such as antacids, probenecid, warfarin, sulfonylureas, and cimetidine. Speak to your doctor before taking any other medications while taking PST.
Food Interactions
Grapefruit juice and other acidic juices may prevent the absorption of Phtalazol tablets 0,5 g, and therefore should be avoided while taking this medication. Additionally, alcoholic beverages should also be avoided.
Pregnancy Use
There is not enough clinical information to recommend the use of Phtalazol tablets 0,5 g in pregnant women. Speak to your doctor before taking PST while pregnant.
Lactation Use
Phtalazol tablets 0,5 g can be used during lactation, as low levels of the drug can be found in breastmilk. It is recommended to take the medication at the end of a nursing session in order to reduce the infant's exposure to the drug.
Acute Overdose
If an overdose of Phtalazol tablets 0,5 g is suspected, consult a healthcare provider immediately. Overdose symptoms include nausea, dizziness, headache, confusion, and blurred vision. Possibility of seizures may also occur.
Contraindication
Phtalazol tablets 0,5 g is contraindicated in patients with a known hypersensitivity to the drug, sulfonamides, and any ingredients in the medication. PST is also not recommended for use in children or pregnant women.
Use Direction & Storage Condition
Phtalazol tablets 0,5 g should be taken as directed by a doctor, usually once a day. The medication should be stored in a cool, dry place, away from direct light and moisture. Unopened medication should be kept in its original package.
Volume of Distribution
The volume of distribution for Phtalazol tablets 0,5 g is approximately 0.3L/kg.
Half Life
The half-life for Phtalazol tablets 0,5 g is approximately 4 hours.
Clearance
The clearance of Phthlaylsulfathiazole is approximately 80 ml/min/kg.
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