Phenylmethyl Benzoate
Phenylmethyl Benzoate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Phenylmethyl Benzoate is a brand name. Its generic name is Benzyl Benzoate.
Introduction
Phenylmethyl Benzoate is a synthetic ester derived from benzoic acid used as a pharmaceutical excipient, a preservative, and as a solubilizing agent. It is a colorless, slightly viscous, and nonflammable liquid that is insoluble in water and oil but soluble in alcohol, propylene glycol, and other organic solvents. It has a fruity, pleasant smell. It is found in cosmetics, fragrances, and detergents.Uses
Phenylmethyl Benzoate is used in pharmaceutical products as a preservative and solubilizing agent. It is also used as a topical medicine to treat lice and scabies. It can also be used to treat pruritus, cystitis, and fungal infections. Additionally, it can be used on the skin as an insect repellent and a preservative in cosmetics.Mechanism of Action
Phenylmethyl Benzoate acts by disrupting the protective barrier on the cuticle of the lice, destroying the louse's protective coating and subsequently killing it. As a preservative, it works by inhibiting the growth of microorganisms and fungi in cosmetics and other products.How Long Does it Take to Work?
Phenylmethyl Benzoate typically takes several hours to take full effect in killing lice. When used as a preservative, it begins inhibiting microbial growth within minutes.Absorption
Phenylmethyl Benzoate is quickly absorbed when applied topically to the skin and quickly eliminated by metabolism.Route of Elimination
Phenylmethyl Benzoate is metabolized to benzoic acid and Benzyl Alcohol, which are both eliminated in the urine.Dosage
Doses of Phenylmethyl Benzoate for topical application vary depending on the application. For lice, it is recommended to use a 1 - 5% solution to be applied to the skin for 12 - 24 hours. For scabies, a 13 - 20% solution is recommended to be applied to the skin for 12 - 24 hours. The maximum tolerated dose should not be exceeded.Administration
Phenylmethyl Benzoate should be administered topically to the skin. It is not to be taken orally or injected.Side Effect
Common side effects of Phenylmethyl Benzoate include burning, itching, flaking, redness of the skin, and a foul odor. Other more serious side effects include rashes, hives, difficulty breathing, and tightness in the chest.Toxicity
Phenylmethyl Benzoate has been classified as an irritant and a mild skin sensitizer. High concentrations may cause skin irritation and sensitization.Precaution
Care should be taken when applying Phenylmethyl Benzoate to ensure that it does not come into contact with eyes, mouth, or mucous membranes. It should not be used on healthy skin or on broken, raw, or inflamed skin. It should also not be used on children younger than two years of age.Interaction
Phenylmethyl Benzoate may interact with other drugs that may be absorbed through the skin, such as benzoyl peroxide, retinoids, or topical antibiotics. It may also interact with other topical products, such as sunscreen or moisturizers.Disease Interactions
Phenylmethyl Benzoate may not be suitable for patients with a history of skin allergies or sensitivities, eczema, psoriasis, or diabetes. It should be used with caution in these cases.Drug Interactions
Phenylmethyl Benzoate may interact with other drugs taken orally or applied topically, such as antibiotics, retinoids, or products containing salicylic acid.Food Interactions
Phenylmethyl Benzoate may interact with certain foods, such as dairy products, eggs, nuts, seafood, and wheat.Pregnancy Use
Phenylmethyl Benzoate should not be used during pregnancy.Lactation Use
Phenylmethyl Benzoate should not be used while breastfeeding.Acute Overdose
An acute overdose of Phenylmethyl Benzoate may cause skin irritation, breathing difficulty, or other serious adverse reactions. Immediate medical attention should be sought if an overdose is suspected.Contraindication
Phenylmethyl Benzoate is contraindicated in patients with known hypersensitivity or allergies to benzoic acid or its derivatives.Use Directions
When using Phenylmethyl Benzoate, it is important to follow any use directions provided by your doctor or pharmacist. If you do not understand the instructions given to you, contact your doctor for clarification.Storage Condition
Phenylmethyl Benzoate should be stored at room temperature away from direct sunlight and heat sources. It should also be kept away from children and pets.Volume of Distribution
The volume of distribution of Phenylmethyl Benzoate is approximately 87.6L.Half Life
The half-life of Phenylmethyl Benzoate in adults is approximately 12.5 hours.Clearance
The clearance of Phenylmethyl Benzoate in adults is approximately 27.7 L/min.Here you find in details version of Phenylmethyl Benzoate
Some Frequently Asked Questions About Phenylmethyl Benzoate
What is Phenylmethyl Benzoate?
Phenylmethyl Benzoate is an ester of Benzoic acid found in a variety of cosmetics, pharmaceuticals, and insect repellents. It acts as a fragrance fixative, viscosity booster, and a preservative in products such as creams, lotions, aftershaves, and colognes.
Why is Phenylmethyl Benzoate used?
Phenylmethyl Benzoate is widely used in a variety of skin and cosmetic products because of its excellent solvent and preservative qualities. It also helps to prevent the product from becoming rancid or losing its fragrance. It helps products maintain their consistency and prolongs shelf life.
What are the skin benefits of Phenylmethyl Benzoate?
Phenylmethyl Benzoate can be a beneficial additive for skin care products. It can help to keep products from becoming rancid, while also keeping the product from becoming contaminated with bacteria or other microorganisms. Additionally, Phenylmethyl Benzoate helps to improve the feel of the product and thicken its consistency.
How does Phenylmethyl Benzoate work?
Phenylmethyl Benzoate is an aromatic ester of Benzoic acid. It acts as a fragrance fixative and helps to prevent the product from losing its scent or becoming contaminated with bacteria or other microorganisms. Phenylmethyl Benzoate also helps to improve the feel of the product and thicken its consistency.
What is the chemical structure of Phenylmethyl Benzoate?
The chemical structure of Phenylmethyl Benzoate is C7H8O2. It is an aromatic ester of Benzoic acid with a clear liquid appearance.
What are the side effects of Phenylmethyl Benzoate?
In general, Phenylmethyl Benzoate is safe and non-toxic when used in topical applications and small, infrequent doses. However, it may cause irritation, dryness, or itching in some people. It is also important to note that due to Phenylmethyl Benzoate's potential for irritation, it should not be used on sensitive areas such as the eyes, and it should not be used on pets.
What is Phenylmethyl Benzoate used for?
Phenylmethyl Benzoate is used in a variety of skin and cosmetic products as a fragrance fixative, viscosity booster, and preservative. It can help to keep products from becoming rancid, while also helping to prevent the product from becoming contaminated with bacteria or other microorganisms. Additionally, Phenylmethyl Benzoate helps to improve the feel of the product and thicken its consistency.
What is the safety of Phenylmethyl Benzoate?
In general, Phenylmethyl Benzoate is safe and non-toxic when used in topical applications and small, infrequent doses. However, it may cause irritation, dryness, or itching in some people. It is also important to note that due to Phenylmethyl Benzoate's potential for irritation, it should not be used on sensitive areas such as the eyes, and it should not be used on pets.
Is Phenylmethyl Benzoate safe for skin contact?
Phenylmethyl Benzoate is generally safe and non-toxic when used in topical applications and small, infrequent doses. However, it may cause irritation, dryness, or itching in some people. It is also important to note that because of its potential for irritation, Phenylmethyl Benzoate should not be used on sensitive areas such as the eyes, and it should not be used on pets.
Is Phenylmethyl Benzoate toxic?
Phenylmethyl Benzoate is generally safe and non-toxic when used in topical applications and small, infrequent doses. However, it may cause irritation, dryness, and itching in some people. Therefore, it is important to note that Phenylmethyl Benzoate should not be used on sensitive areas such as the eyes, and it should not be used on pets.
What products contain Phenylmethyl Benzoate?
Phenylmethyl Benzoate is found in a variety of skin and cosmetic products such as creams, lotions, aftershaves, colognes, deodorants, and insect repellents. It is also an ingredient in some pharmaceuticals.
What is the shelf life of a product containing Phenylmethyl Benzoate?
The shelf life of a product containing Phenylmethyl Benzoate depends on its formulation, production process, packaging, storage conditions, and other factors. Generally, products containing Phenylmethyl Benzoate have a shelf life of 1-2 years.
Is Phenylmethyl Benzoate a natural ingredient?
No, Phenylmethyl Benzoate is a synthetic ingredient that is derived from the reaction of benzoic acid and benzyl alcohol.
Is Phenylmethyl Benzoate safe for pregnant women?
It is recommended that pregnant women avoid the use of products containing Phenylmethyl Benzoate as it may be absorbed through the skin. It is best to consult with a doctor before using such products.
Is Phenylmethyl Benzoate safe for children?
Phenylmethyl Benzoate is generally considered to be safe when used in small, infrequent doses, but it is still recommended to consult with a doctor before using such products on children.
What is the molecular formula of Phenylmethyl Benzoate?
The molecular formula of Phenylmethyl Benzoate is C7H8O2.
How is Phenylmethyl Benzoate made?
Phenylmethyl Benzoate is made through the reaction of benzoic acid and benzyl alcohol. Depending on the method of production, different grades of Phenylmethyl Benzoate may be produced.
Is Phenylmethyl Benzoate a volatile compound?
Yes, Phenylmethyl Benzoate is a volatile compound and has a boiling point of 243°C.
Is Phenylmethyl Benzoate petroleum-based?
No, Phenylmethyl Benzoate is derived from plant-based materials and is not petroleum-based.
What is the boiling point of Phenylmethyl Benzoate?
The boiling point of Phenylmethyl Benzoate is 243°C.
Is Phenylmethyl Benzoate used in cosmetics?
Yes, Phenylmethyl Benzoate is commonly used in many skin care and cosmetic products as a preservative, fragrance fixative, and viscosity booster. It also helps to prevent the product from becoming rancid or losing its fragrance.
Does Phenylmethyl Benzoate absorb water?
Yes, Phenylmethyl Benzoate is hygroscopic, meaning it has the ability to absorb moisture from the air.
Does Phenylmethyl Benzoate cause skin irritation?
Phenylmethyl Benzoate may cause skin irritation in some people. Therefore, it is important to be aware of any potential irritation, dryness, or itching reactions, and discontinue use of the product if irritation occurs.
What is the odor of Phenylmethyl Benzoate?
The odor of Phenylmethyl Benzoate is sweet and balsamic.
Is Phenylmethyl Benzoate combustible?
Yes, Phenylmethyl Benzoate is combustible and needs to be stored away from sources of heat.
Can Phenylmethyl Benzoate be used in pharmaceuticals?
Yes, Phenylmethyl Benzoate is commonly used in a variety of pharmaceuticals, such as drugs, tablets, liquids, and creams.
What is the melting point of Phenylmethyl Benzoate?
The melting point of Phenylmethyl Benzoate is 18-21°C.
Can Phenylmethyl Benzoate be used to repel insects?
Yes, Phenylmethyl Benzoate is commonly used in a variety of insect repellents, such as mosquito repellents. It is important to follow the instructions on the product.
What is the Flash Point of Phenylmethyl Benzoate?
The flash point of Phenylmethyl Benzoate is 99°C.
Is Phenylmethyl Benzoate flammable?
Yes, Phenylmethyl Benzoate is flammable and needs to be stored away from sources of heat.
Can Phenylmethyl Benzoate be ingested?
No, Phenylmethyl Benzoate should not be ingested as it may be toxic if ingested in large amounts.
Can Phenylmethyl Benzoate be used as a preservative?
Yes, Phenylmethyl Benzoate is commonly used in a variety of skin care and cosmetic products as a preservative.
Is Phenylmethyl Benzoate toxic to humans?
In general, Phenylmethyl Benzoate is safe and non-toxic when used in topical applications and small, infrequent doses. However, it may be toxic when ingested in large amounts.
Is Phenylmethyl Benzoate water-soluble?
Yes, Phenylmethyl Benzoate is water-soluble and can easily be dissolved in oil.
Does Phenylmethyl Benzoate penetrate the skin?
Yes, Phenylmethyl Benzoate may be absorbed through the skin when applied topically, though the amount of absorption is typically limited.
Is Phenylmethyl Benzoate a photosensitizer?
No, Phenylmethyl Benzoate is not a photosensitizer and will not cause any sensitization or sun-sensitivity reactions.
Can Phenylmethyl Benzoate be used in bath preparations?
Yes, Phenylmethyl Benzoate is often used in bath preparations, such as bath salts, since it helps to improve the feel of the product and thicken its consistency.
Is Phenylmethyl Benzoate an endocrine disruptor?
No, Phenylmethyl Benzoate is not an endocrine disruptor and does not cause any disruption to the body's normal hormone production.
Is Phenylmethyl Benzoate a carcinogen?
No, Phenylmethyl Benzoate is not a known carcinogen.