Diisopropyl Phosphofluoridate

Diisopropyl Phosphofluoridate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Diisopropyl Phosphofluoridate is a brand name. Its generic name is Isoflurophate.

Diisopropyl Phosphofluoridate: Overview

Diisopropyl Phosphofluoridate is an organophosphate used in agricultural pesticide formulations and to treat certain insurrections in trees. Isofluorophate blocks the action of an enzyme in the body, acetylcholinesterase, which is needed for nerve cells to function properly. It works by inhibiting acetylcholinesterase and thus preventing the breakdown of acetylcholine, a neurotransmitter.

Uses for Isofluorophate

It is used to treat certain insect infestations in trees, such as black knot of chestnut and pear, and in agricultural pesticide formulations.

Mechanism of Action

Isofluorophate functions by inhibiting acetylcholinesterase, an enzyme responsible for breaking down acetylcholine. This prevents the breakdown of acetylcholine, which is needed by nerve cells to function properly.

How Long Does it Take to Work?

It usually takes a few days for isofluorophate to start working. The effects of isofluorophate vary from person to person, and it may take longer to start working in some people.

Absorption

Isofluorophate is readily absorbed through the skin and digestive tract.

Route of Elimination

Isofluorophate is eliminated primarily through the kidneys.

Dosage

Isofluorophate should be administered as recommended by your healthcare provider. Generally, the following guidelines should be followed:
  • Adults: 1-2 g orally every 4-6 hours as needed.
  • Children: 0.5-1 g orally every 4-6 hours as needed.

Administration

Isofluorophate can be taken orally or applied topically (on the skin). It is important to follow the instructions of your healthcare provider when taking or applying isofluorophate.

Side Effects

Common side effects of isofluorophate include nausea, vomiting, dizziness, fatigue, headache, blurred vision, weakness, and dry mouth.

Toxicity

Isofluorophate can be toxic if taken in high doses or for long periods of time. Symptoms of isofluorophate toxicity include increased salivation, muscle weakness, blurred vision, confusion, seizures, and respiratory paralysis.

Precaution

Isofluorophate should not be taken by pregnant or breastfeeding women, as it may cause fetal or infant harm. Care should be taken to avoid the inhalation, ingestion, or absorption of isofluorophate through the skin. In case of accidental exposure, seek medical attention immediately.

Interaction

Isofluorophate may interact with other medications, including anticholinergics (such as atropine), anticholinesterase agents (such as pyridostigmine), and other organophosphates. As such, it is important to inform your healthcare provider of any medications you are taking prior to taking isofluorophate.

Disease Interaction

Isofluorophate may worsen symptoms of existing medical conditions, such as asthma, emphysema, and chronic bronchitis. As such, it is important to inform your healthcare provider of any existing medical conditions prior to taking isofluorophate.

Drug Interaction

Isofluorophate may interact with other medications, including anticholinergics (such as atropine), anticholinesterase agents (such as pyridostigmine), and other organophosphates. As such, it is important to inform your healthcare provider of any medications you are taking prior to taking isofluorophate.

Food Interactions

Isofluorophate does not typically interact with food. However, it is important to tell your healthcare provider of any medications, supplements, or herbs you may be taking prior to taking isofluorophate.

Pregnancy Use

Isofluorophate should not be taken by pregnant women, as it may cause fetal harm. It is important to tell your healthcare provider if you are pregnant prior to taking isofluorophate.

Lactation Use

Isofluorophate should not be taken by breastfeeding women, as it may cause infant harm. It is important to tell your healthcare provider if you are breastfeeding prior to taking isofluorophate.

Acute Overdose

In case of an acute overdose, seek medical attention immediately. Symptoms of an isofluorophate overdose include increased salivation, muscle weakness, blurred vision, confusion, seizures, and respiratory paralysis.

Contraindication

Isofluorophate use is contraindicated in individuals with known hypersensitivity to it or any of its components. It is also contraindicated in pregnant and breastfeeding women, as it may cause fetal or infant harm.

Use Directions

Isofluorophate should be used only as directed by your healthcare provider. Follow all instructions carefully, and do not exceed the recommended dose.

Storage Condition

Isofluorophate should be stored at room temperature, away from moisture and heat.

Volume of Distribution

Isofluorophate is distributed throughout the body.

Half Life

The half-life of isofluorophate is approximately 8 hours.

Clearance

Isofluorophate is cleared by the kidneys.

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