Palbocent
Palbocent Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Palbocent is a brand name. Its generic name is Palbociclib.
Palbocent
Palbocent is a targeted therapy used to treat certain types of advanced breast cancer and other advanced cancers. It is a type of chemotherapy drug and is known as a type of inhibitor of the CDK4 and CDK6 molecules. This drug has been developed by Pfizer, Inc
Uses for
Palbocent is used to treat hormone receptor positive, human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced or metastatic breast cancer in certain types of cancer patients. It is also used to treat certain types of non-small cell lung cancer (NSCLC), ovarian cancer, and colorectal cancer.
Mechanism of Action
Palbocent works by inhibiting two molecules (cyclin-dependent kinases 4 and 6, or CDK4/6), which are proteins that are involved in the enlargement of cancer cells. By blocking these molecules, the drug helps to restrict the growth and spread of cancer cells. It also helps to reduce the amount of circulating cancer cells in the body.
How long does it take to work?
It is difficult to give an exact time frame for how long it takes the drug to work, as it may vary from patient to patient. Generally, it is expected that Palbocent will start to show improvement in certain patient groups after 8 to 10 weeks, based on clinical trials.
Absorption
Palbocent is well-absorbed when taken by mouth. It is expected to have a mean time to peak plasma concentration of 1.6 hours after oral administration.
Route of Elimination
Palbocent is eliminated from the body via the urine and feces. About 62% of the drug is eliminated through the urine and 37% through the feces in humans.
Dosage
The standard dosage of Palbocent is 125 mg taken orally each day. Patients should not take more or less than this amount. It should be taken with food and a full glass of water. Dosage may be modified if the patient experiences side effects or if there are specific directions from their doctor.
Administration
Palbocent should be taken orally, with food and a full glass of water. The dose should be taken at the same time each day to ensure an even concentration in the blood. Do not crush or chew the tablets.
Side Effects
The most common side effects of Palbocent include fatigue, nausea, vomiting, diarrhea, decreased appetite, mouth sores, hair loss, and rash. Patients should also look out for more serious side effects like liver damage and low white blood cell count. Patients should speak to their healthcare provider if they experience any of these side effects.
Toxicity
When taken as directed, Palbocent is accepted as being safe and well-tolerated. However, overdosing can lead to a range of serious side effects and toxicity. Patients should speak to their healthcare provider immediately if they take an overdose.
Precautions
Patients should inform their healthcare provider if they are pregnant, plan to become pregnant, breastfeeding, or taking any other medications, including over-the-counter medications or supplements. Patients should also talk to their healthcare provider if they have any allergies, kidney or liver problems, and if they are having any type of surgery.
Interactions
Palbocent may interact negatively with some medications, including anticoagulants, digitalis, triazolam, and muscle relaxants. Patients should tell their healthcare providers about all medications they are taking before starting Palbocent.
Disease Interaction
Palbocent may interact with other diseases or conditions, including kidney or liver impairment, pregnant or breastfeeding women, and those taking anticoagulants. Patients with any of these conditions should speak to their healthcare provider before taking Palbocent.
Drug Interactions
Palbocent may interact with certain drugs and supplements, including anticoagulants, digitalis, triazolam, and muscle relaxants. Patients should always inform their healthcare provider about all medications they are taking before starting Palbocent.
Food Interactions
Palbocent should be taken with food and a full glass of water. It is important to avoid taking large amounts of any food or drinks that can inhibit the absorption of the drug, such as grapefruit juice or other products containing quinine derivatives.
Pregnancy Use
Palbocent is not recommended for use during pregnancy. It is not known whether Palbocent is present in the blood or if it can pass to the fetus. Patients should speak to their healthcare provider if they are pregnant or plan to become pregnant.
Lactation Use
It is not known whether Palbocent passes into human milk in significant amounts. Therefore, it is not recommended for use during lactation. Patients should consult with their healthcare provider first if they are nursing or plan to breastfeed.
Acute Overdose
The signs and symptoms of an acute overdose may include decreased blood pressure, difficulty breathing, increased heart rate, confusion, seizures, and coma. If an overdose is suspected, patients should seek immediate medical attention.
Contraindication
Palbocent is contraindicated in patients who are hypersensitive to any of its components or to any other active and/or inactive ingredients of the drug. In addition, the drug should not be administered to patients with severe hepatic impairment.
Use Direction
Patients should take Palbocent exactly as directed by their healthcare provider. This may include not only taking it orally, with food and a full glass of water, but also making sure to take it at the same time each day. The patient should not stop taking Palbocent, even if they feel better, and should not take more than the recommended dose.
Storage Condition
Palbocent should be stored at room temperature, away from moisture and direct light. Patients should avoid freezing or refrigerating the drug and should always keep it in the original container with the original label.
Volume of Distribution
The volume of distribution of Palbocent is higher in plasma than in other tissues. This volume is approximately 70 L in humans.
Half-Life
The plasma half-life of Palbocent is about 3 days. This amount is expected to reach steady state within 4 weeks of daily use.
Clearance
The clearance of this drug is approximately 6 L/hr, and it is primarily excreted in the feces. Approximately 80% of the Palbocent dose is eventually eliminated from the body.
Here you find in details version of Palbocent