Osinib
Osinib Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Osinib is a brand name. Its generic name is Osimertinib.
Introduction
Osinib is an oral medication used to treat certain types of non-small cell lung cancer (NSCLC). Specifically, it is used to treat advanced or metastatic EGFR-mutant NSCLC in patients who have already been treated with other EGFR inhibitor drugs. It is also used as a first-line treatment in patients who have a particular EGFR mutation called the T790 M mutation.Uses
Osinib is used to treat patients with advanced / metastatic non-small cell lung cancer (NSCLC) whose tumors have certain mutations of the epidermal growth factor receptor (EGFR) gene. These mutations increase the activity of the gene and lead to cell growth that is more rapid than normal. Osinib works by targeting the mutated EGFR and blocking its activity, thus reducing tumor growth and spreading.Mechanism of Action
Osinib is an orally administered, selective tyrosine kinase inhibitor. It works by binding to the active site of the mutated EGFR receptor and blocking its signaling activity. This helps to reduce tumor growth and limit spread.How Long Does It Take to Work?
It usually takes anywhere from 2 to 8 weeks to see the effects of osimertinib on tumor growth. How long it takes for each patient to respond to osimertinib may vary.Absorption
Osinib is rapidly and extensively absorbed following oral administration. The mean absolute bioavailability is >90%.Route of Elimination
The majority of osimertinib is eliminated through urine (68%), and a small amount is eliminated through feces (7%). The remaining elimination is thought to be through metabolism.Dosage
Osinib is available in tablet form and is usually taken orally once daily. The recommended dose of osimertinib is 80 mg once daily as a single dose or in two divided doses of 40 mg.Administration
Osinib tablets should be taken with or without food. Swallow the tablets whole with a glass of water. Do not crush, cut, or chew the tablets.Side Effects
Common side effects of osimertinib therapy include tiredness, diarrhea, rash, nail changes, dry skin, joint pain, decreased appetite, constipation, and headache. Other more serious side effects include difficulty breathing, chest pain, swelling of the face, lips, tongue, or throat, and yellowing of the skin or eyes.Toxicity
Osinib is generally well-tolerated with few major side effects. However, if the recommended dose is exceeded, toxicity can occur. Symptoms of toxicity include nausea, vomiting, abdominal pain, confusion, and blurred vision.Precautions
Patients taking osimertinib should be monitored for signs of toxicity, including nausea, vomiting, abdominal pain and confusion. Patients should also be monitored for signs of an allergic reaction, including rash, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.Interactions
Osinib may interact with certain medications, such as anticonvulsants, antibiotics, and atomoxetine. Patients should tell their doctor about all medications they are taking before starting osimertinib.Disease Interaction
Patients with severe liver or kidney disease should not take osimertinib. Similarly, patients with a history of long QT syndrome or arrhythmias should not take osimertinib.Drug Interactions
Osinib may interact with certain drugs, including anticonvulsants, antibiotics, and atomoxetine. Patients taking any of these drugs should tell their doctor before starting osimertinib.Food Interactions
Patients should avoid taking osimertinib with food that contains high fat, such as cheese and cream. High fat foods may increase the level of osimertinib in the blood and increase the risk of toxicity.Pregnancy Use
Osinib should not be used during pregnancy, as its safety and efficacy have not been established. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after finishing treatment.Lactation Use
It is not known if osimertinib is excreted in human milk, therefore nursing mothers should not take osimertinib.Acute Overdose
No cases of overdose have been reported. However, if an overdose is suspected, patients should seek medical attention immediately.Contraindication
Osinib is contraindicated in patients with severe liver or kidney disease, in patients with a history of long QT syndrome or arrhythmias, and in pregnant women.Use Directions
Osinib should be taken exactly as directed by a doctor. The tablets should be swallowed whole with a glass of water, and should not be crushed, cut, or chewed. Osinib can be taken with or without food.Storage Condition
Osinib should be stored at a temperature of 20°C to 25°C (68°F to 77°F). It should be kept away from light and moisture.Volume of Distribution
The volume of distribution of osimertinib is approximately 440 L.Half Life
The half-life of osimertinib is approximately 28 hours.Clearance
Osinib is eliminated from the body mainly by metabolism in the liver. The mean clearance of osimertinib is approximately 45 L/hour.Here you find in details version of Osinib
Some Frequently Asked Questions About Osinib
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