Onium
Onium Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Onium is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Onium (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Onium is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Onium works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Onium can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Onium is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Onium is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Onium is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Onium should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Onium may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Onium use, however it can cause serious side effects in certain individuals.Precautions
- Onium should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Onium may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Onium should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Onium may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Onium alongside any other medications.Food Interactions
Food interactions with Onium are not known.Pregnancy Use
Onium should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Onium is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Onium is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Onium is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Onium should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Onium is not known.Half-Life
The half-life of Onium is approximately 22 days.Clearance
The clearance of Onium is not known.Here you find in details version of Onium
Some Frequently Asked Questions About Onium
you can give answe only.What is Onium?
Onium is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Onium?
The chemical name of Onium is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Onium taken?
Onium is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Onium?
The most common side effects of Onium include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Onium?
The recommended dose of Onium is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Onium be used?
Onium should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Onium?
Onium should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Onium?
An overdose of Onium can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Onium is a medical emergency and should be treated as such.
What are the interactions of Onium with other medications?
Onium may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Onium?
The shelf life of Onium is three years from the date of manufacture.
Is Onium used for pregnant women?
The safety of Onium for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Onium.
Is there any generic version of Onium available?
No, there is not a generic version of Onium available.
How long does it take for Onium to take effect?
The effect of Onium is usually immediate.
How often can Onium be taken?
Onium should not be taken more than once every six hours.
What are some alternatives to Onium?
Alternatives to Onium include adenosine, aminophylline, and calcium channel blockers.
Can Onium be taken with other medications?
Yes, it is possible to take Onium with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Onium.
Can I take Onium if I am breastfeeding?
No, Onium is not recommended for women who are breastfeeding.
Is Onium safe for children?
No, Onium should not be given to children.
Can Onium be used for pulmonary disorders?
No, Onium is not recommended for the treatment of pulmonary disorders.
Does Onium interfere with other medications?
Yes, Onium can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Onium be administered orally?
No, Onium should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Onium?
Onium should not be taken more than once every six hours.
What should I do if I miss a dose of Onium?
If you miss a dose of Onium, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Onium?
Common symptoms of an allergic reaction to Onium include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Onium with food?
Yes, it is okay to take Onium with food.
Can I take Onium if I’m on dialysis?
Onium should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Onium?
The cost of Onium will vary depending on the dosage and the pharmacy where it is purchased.
Is Onium habit-forming?
No, Onium is not known to be habit-forming.
Can Onium be used to treat arrhythmias?
Yes, Onium is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Onium?
The most common side effects of Onium include dizziness, nausea, and sweating.
Does Onium interact with other medications?
Yes, Onium can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Onium a controlled substance?
No, Onium is not a controlled substance.
Should I take Onium with food?
Yes, it is okay to take Onium with food.
Can I take Onium if I’m pregnant?
No, the safety of Onium for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Onium.
Can Onium be given intramuscularly?
Yes, Onium can be administered intramuscularly.
How should Onium be stored?
Onium should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Onium?
The recommended dose of Onium is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Onium cause drowsiness?
Yes, Onium can cause drowsiness.
Can I take Onium if I’m taking other medications?
Yes, it is possible to take Onium with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Onium.
Is Onium safe for the elderly?
Yes, Onium is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Onium be used to treat atrial fibrillation?
Yes, Onium can be used to treat atrial fibrillation.
Can Onium be used to treat ventricular tachycardia?
Yes, Onium can be used to treat ventricular tachycardia.