NPH
NPH Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? NPH is a brand name. Its generic name is Hydrocortisone + Neomycin Sulphate + Polymixin B.
Introduction
NPH is a topical combination drug used to treat a variety of skin conditions. It contains hydrocortisone (a corticosteroid), neomycin sulfate (an antibiotic), and polymyxin B (a polypeptide antibiotic).Uses For
NPH is used to treat minor cuts, scrapes, and burns, as well as bacterial, fungal and allergic skin reactions such as eczema, psoriasis, and dermatitis. It can also be used to treat insect bites and stings, or skin infections caused by bacteria, fungi, and viruses.Mechanism of Action
Hydrocortisone is a corticosteroid that acts to reduce inflammation and itching. Neomycin sulfate is an antibiotic that helps prevent and reduce the growth of bacterial and fungal infections. Polymyxin B is a polypeptide antibiotic that works by binding to the bacterial cell walls. This helps to stop the bacteria from growing and spreading, allowing the skin to heal.How Long Does It Take To Work
NPH typically takes about 5-7 days to start working, but the effects can vary depending on the severity of the skin condition.Absorption
Hydrocortisone is quickly absorbed through the skin and is thought to have a limited systemic absorption. Neomycin sulfate and Polymyxin B have a higher absorption rate to the point where systemic effects have been occasionally reported.Route of Elimination
Hydrocortisone is metabolized in the liver to inactive metabolites which are then excreted by the kidneys. Neomycin sulfate and polymyxin B are both metabolized in the liver and excreted in the feces.Dosage
The usual dose of NPH is 0.5%-1% for adults and 0.25%-0.5% for children.Administration
NPH should be applied topically to the affected area three to four times a day, or as directed by a physician.Side Effects
Common side effects of NPH include burning, stinging, itching, redness, dryness, mild skin irritation, and rash. Systemic effects from systemic absorption are rare but can include headache, blurred vision, nausea, vomiting, dizziness, and insomnia.Toxicity
Hydrocortisone is generally well tolerated when used as directed. Neomycin sulfate and polymyxin B are both generally safe for topical use.Precautions
It is important not to use NPH on large areas of skin, as this increases the risk of systemic absorption. It is also important to avoid getting the medication in the eyes or mouth, as this can cause irritation or infection.Interactions
NPH may interact with other medications, particularly those that affect the liver or kidneys. It is important to speak to a physician before using any other medications with this product.Disease Interactions
NPH should be used with caution in patients with liver or kidney disease, as these medications can affect the function of these organs.Drug Interactions
NPH has the potential to interact with other medications, especially those that affect the liver or kidneys. Talk to your doctor before using this product with any other drugs.Food Interactions
NPH has no known food interactions.Pregnancy Use
NPH should be used with caution in pregnant women, as the potential effects on the fetus are not known.Lactation Use
NPH should be used with caution in nursing mothers, as the potential effects on the breastfeeding infant are not known.Acute Overdose
An acute overdose of NPH is unlikely to occur. However, if an overdose is suspected, seek medical attention immediately.Contraindication
NPH should not be used in patients with known hypersensitivity to any of the components.Use Direction
NPH should be applied to the affected area three to four times a day, or as directed by a physician. Do not apply to large areas of skin, as this increases the risk of systemic absorption.Storage Condition
NPH should be stored at room temperature (15-30°C) in an airtight container.Volume of Distribution
The volume of distribution of NPH is unknown.Half Life
The half-life of NPH is unknown.Clearance
The clearance of NPH is unknown.Here you find in details version of NPH