NovoEight
NovoEight Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? NovoEight is a brand name. Its generic name is Antihemophilic factor human.
Introduction
Antihemophilic Factor Human (Factor VIII; also known as antihemophilic globulin A) is a recombinant human coagulation factor that is used to replace the factor viii protein missing in people with Hemophilia A, a genetic disorder that affects the body’s blood clotting process.
Uses
Universal use of Antihemophilic Factor Human is for the treatment of acute bleeding episodes, surgery, and as prophylaxis of bleeding in people suffering from Hemophilia A.
Mechanism of Action
Antihemophilic Factor Human works by promoting the formation of fibrin and stabilizing the blood clot. It binds to another coagulation factor, Factor IX, to form the active complex, which then goes on to catalyze the conversion of Factor X to its active form Xa, leading to the formation of the fibrin clot.
How Long Does it Take to Work?
The time until the onset of the therapeutic effect of Antihemophilic Factor Human depends on several factors, including the type of hemophilia and the dose. It usually takes 15-60 minutes to have an effect on bleeding.
Absorption
Antihemophilic Factor Human is administered intravenously, and is quickly absorbed into the circulation.
Route of Elimination
Antihemophilic Factor Human is cleared primarily through the liver and is eliminated mainly in the form of inactive fragments in the urine.
Dosage
The recommended dose of Antihemophilic Factor Human is based on severity of the factor VIII deficiency, patient's age, and presence of inhibitors. The usual starting dose is 40-120 IU/kg body weight every 12-24 hours until the bleeding is controlled. The dose may need to be adjusted according to the patient's response.
Administration
Antihemophilic Factor Human is usually administered intravenously, although it can also be administered intramuscularly, subcutaneously, or topically. For intravenous infusion, the solution should be given at a rate of up to 2 units/minute.
Side Effects
Common side effects of Antihemophilic Factor Human include dizziness, headache, nausea, vomiting, muscle cramps, and local reaction at the injection site. Rare side effects include allergic reactions, thrombosis, and increased risk of infection.
Toxicity
Toxic effects have not been reported with Antihemophilic Factor Human.
Precautions
Antihemophilic Factor Human should be used with caution in patients with a history of thromboembolic disorders, infection, or allergic reactions to human blood products.
Interactions
Antihemophilic Factor Human may interact with some anticoagulants, antiplatelet drugs, and some other drugs. It is important to tell your doctor about any medications you are taking before taking Antihemophilic Factor Human.
Disease Interactions
Antihemophilic Factor Human may interact with some diseases, including hemophilia A. It should be used with caution in patients with thromboembolic disorders, infections, or allergenic reactions to human blood products.
Drug Interactions
Antihemophilic Factor Human may interact with some drugs, including anticoagulants, antiplatelet drugs, and some other drugs. It is important to tell your doctor about any medications you are taking before taking Antihemophilic Factor Human.
Food Interactions
There are no known food interactions associated with Antihemophilic Factor Human.
Pregnancy Use
It is not known if Antihemophilic Factor Human is safe to use during pregnancy. Consult your doctor before using this medication if you are pregnant.
Lactation Use
It is not known if Antihemophilic Factor Human is safe to use during lactation. Consult your doctor before using this medication if you are breastfeeding.
Acute Overdose
No serious consequences are expected from an acute overdose of Antihemophilic Factor Human.
Contraindication
Antihemophilic Factor Human is contraindicated in patients with hypersensitivity to the drug, as well as in patients with thrombotic disorder, or in patients with thrombotic episodes during treatment with previous antihemophilic factor.
Use Direction
Follow your physician's instructions exactly when using Antihemophilic Factor Human. Do not exceed the recommended dose.
Storage Condition
Antihemophilic Factor Human should be stored in the refrigerator at 2-8°C and should not be exposed to light or heat.
Volume of Distribution
The volume of distribution of Antihemophilic Factor Human is not known.
Half Life
The half-life of Antihemophilic Factor Human is 9-12 hours.
Clearance
The clearance of Antihemophilic Factor Human is not known.
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