Optivate and solvent
Optivate and solvent Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Optivate and solvent is a brand name. Its generic name is Coagulation Factor VIIa (Eptacog Alfa).
Introduction
Optivate and solvent is a therapeutic protein produced through recombinant DNA technology, and it is the active form of factor VII (FVII). This recombinant coagulation factor can be used to improve hemostasis (blood clotting) in bleeding disorders and conditions.Uses
Optivate and solvent is used to improve hemostasis (blood clotting) in patients who have a deficiency of Factor VII (FVII). This therapy helps to reduce the amount of time it takes for blood to clot in patients with certain bleeding disorders and conditions. It is used to treat:- Congenital Factor VII (FVII) Deficiency
- Hemophilia A and B (Factor VIII and IX Deficiency)
- Glanzmann's Thrombasthenia (GT)
- Von Willebrand Disease (VWD)
- Elevated FVII:C in Neonatal Alloimmune Thrombocytopenia (NAIT)
- Vascular Anomalies with Bleeding Complications
- Glanzmann’s Thrombasthenia with Bleeding Complications
Mechanism of Action
Optivate and solvent works by decreasing the time it takes for blood to clot. It does this by activating the intrinsic and extrinsic coagulation pathways which are involved in the formation of a clot. This therapy also activates coagulation Factor X (FX), which in turn helps to produce factor II (FII), which is required for the intrinsic coagulation pathway.How Long Does It Take to Work?
Optivate and solvent usually starts to work within 20 minutes of administration. It can reach peak plasma concentrations between 30 minutes and 3 hours after administration.Absorption
Optivate and solvent is rapidly absorbed after administration and reaches peak plasma concentrations between 30 minutes and 3 hours after administration.Route of Elimination
Optivate and solvent is eliminated mainly through the kidneys as unchanged protein and metabolites.Dosage
The recommended dosage of Optivate and solvent depends on the patient's condition. For congenital FVII deficiency, the usual dosage is 250 to 500mcg/kg given intravenously every 24 to 48 hours. For hemophilia A and B, Glanzmann's Thrombasthenia (GT) and von Willebrand Disease (VWD), the usual dosage is 250 to 500mcg/kg given intravenously every 24 hours. For vascular anomalies with bleeding complications, a loading dose of 250 to 500mcg/kg is given and then repeated every 24 to 48 hours as needed. For Glanzmann’s Thrombasthenia with bleeding complications, the usual dosage is 250 to 500mcg/kg every 48 to 72 hours.Administration
Optivate and solvent is usually administered intravenously as a single dose or infusion over a period of time. The injection site should be rotated with each dose and the injection should be made slowly to avoid any pain.Side Effects
The most common side effects of Optivate and solvent therapy are fever, rash, headache, nausea, vomiting, diarrhea, and vomiting blood. These symptoms usually resolve within 24 hours of administration. Other possible side effects include allergic reactions, thromboembolism (clotting in the blood vessels), and changes in the liver enzymes.Toxicity
Optivate and solvent is not known to be toxic when used as directed. However, if it is administered in excessive doses, it can cause serious side effects.Precautions
Optivate and solvent should be used with caution in patients with bleeding or clotting disorders, those on anticoagulant therapy, and those who are undergoing surgery or have a history of thrombosis (clotting in the blood vessels).Interaction
Optivate and solvent may interact with other medicines or supplements that the patient is taking. It is important to inform your physician or healthcare provider if you are taking any other medicines or supplements.Disease Interaction
Optivate and solvent can interact with certain diseases and conditions. It is important to inform your healthcare provider if you have any medical conditions before starting this therapy.Drug Interaction
Optivate and solvent may interact with certain drugs. It is important to inform your healthcare provider if you are taking any other drugs before starting this therapy.Food Interactions
Optivate and solvent may interact with certain foods. It is important to inform your healthcare provider of any dietary restrictions before starting this therapy.Pregnancy use
Optivate and solvent has not been studied in pregnant women and is not recommended for use during pregnancy.Lactation use
Optivate and solvent has not been studied in breastfeeding women and is not recommended for use during breastfeeding.Acute Overdose
Acute overdose of Optivate and solvent may cause serious side effects and should be treated promptly. Symptoms of overdose include excessive bleeding, thrombosis (clotting in the blood vessels), and changes in vital signs such as blood pressure and heart rate.Contraindication
Optivate and solvent is contraindicated in patients with a known hypersensitivity to the drug. It is not recommended for use in patients with active thrombosis (clotting in the blood vessels) or with known factor VII (FVII) inhibitors.Instructions for Use
Optivate and solvent is usually administered intravenously as a single dose or infusion over a period of time. It should be used as directed by your healthcare provider.Storage Conditions
Optivate and solvent should be stored at room temperature and protected from light. It should be discarded if it has been exposed to temperatures above 77°F (25°C).Volume of Distribution
Optivate and solvent has a volume of distribution of approximately 1.5 L/kg.Half Life
The half-life of Optivate and solvent is approximately 33 minutes.Clearance
Optivate and solvent is cleared primarily through the kidneys. The clearance of this medication is approximately 10 mL/min/kg.Here you find in details version of Optivate and solvent