NIZ
NIZ Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? NIZ is a brand name. Its generic name is Nitazoxanide.
Introduction
NIZ is an anthelmintic and anti-protozoal drug used to treat various parasitic infections such as giardiasis, cryptosporidiosis, and trichomoniasis, as well as helminthic infections like ascariasis and hookworm. It is available in oral and intravenous solutions.Uses
NIZ is used to treat the following infections: Giardia lamblia, Cryptosporidium, Trichomonas vaginalis, Ascariasis, Enterobius vermicularis, Ancylostoma duodenale and Necator americanus.Mechanism of Action
NIZ works by inhibiting the cytopathic effect of certain protozoa and helminths. It may works by interfering with DNA and RNA synthesis and by inhibiting the development of the parasites.How Long Does it take to Work?
The time it takes for nitazoxanide to take effect varies and depends on the type of infection being treated. Generally, it begins to work within hours or days after ingestion, however, in order for full effectiveness, it may be necessary to continue taking nitazoxanide for several weeks or months.Absorption
NIZ is absorbed quickly and completely when taken orally. The peak plasma concentration reaches within one hour of dosing.Route of Elimination
NIZ is eliminated mainly through the feces. It is not known to be excreted in urine.Dosage
NIZ is available in tablet form in the following dosages:- Adult dose: 500 mg twice daily for three days.
- Children 2-11 years: one 11-30 mg/kg/day in two divided doses (maximum 500 mg/day) three days duration or two divided doses (maximum 12 mg/kg/day) for five days.
- Children 1-2 years: 11 mg/kg/day in two divided doses (maximum 500 mg/day) three days duration or two divided doses (maximum 12 mg/kg/day) for five days.
Administration
NIZ should be taken orally, with food or milk to reduce gastrointestinal side effects. It should be swallowed whole with a glass of water without crushing, splitting or chewing the tablet.Side Effects
Common side effects of NIZ include: nausea, vomiting, abdominal pain, headache, dizziness, and diarrhea. Serious side effects are rare, but may include an increased risk of developing an infection, liver toxicity, or allergic reactions.Toxicity
NIZ is generally considered to be safe at recommended doses. An acute overdose of nitazoxanide can lead to vomiting, diarrhea, tremors, increased heart rate, and confusion.Precautions
Patients should inform their healthcare provider if they have a history of liver or kidney disease before taking NIZ. In addition, it is important to drink plenty of fluids while taking this medication to reduce the risk of dehydration.Interactions
NIZ may interact with other medications, including antibiotics, antifungals, and anticonvulsants. It should not be taken with the anticonvulsants phenobarbital and primidone. Patients should inform their healthcare provider of all medications they are taking before starting NIZ.Disease Interaction
Patients with a history of liver or kidney disease should not take NIZ. In addition, this medication should be used cautiously in patients with decreased kidney function, as it is excreted mainly by the kidneys.Drug Interaction
Drugs that may interact with NIZ include antibiotics, antifungals, anticonvulsants, and antidiabetics. It should not be taken with the anticonvulsants phenobarbital and primidone. Patients should inform their doctor of all medications they are taking before starting NIZ.Food Interactions
NIZ can be taken with or without food. Taking the medication with food may reduce gastrointestinal side effects.Pregnancy Use
NIZ should not be used during pregnancy as it may cause harm to the unborn baby.Lactation Use
NIZ is not known to pass into breast milk and can be used by breastfeeding mothers. However, caution should be exercised as there have not been sufficient studies to assess the safety of this drug in breastfeeding women.Acute Overdose
An acute overdose of NIZ can result in vomiting, diarrhea, tremors, increased heart rate, and confusion. Treatment of an overdose usually involves supportive care, such as intravenous fluids to prevent dehydration and monitor vital signs.Contraindication
NIZ should not be used in patients with a known hypersensitivity to the drug. It should also not be used in pregnant or breastfeeding women, or in patients with a history of liver or kidney disease.Use Direction
NIZ should be taken orally, with food or milk to reduce gastrointestinal side effects. It should be swallowed whole with a glass of water without crushing, splitting or chewing the tablet.Storage Condition
NIZ should be stored at room temperature away from light and moisture. Do not store in the bathroom. Keep out of the reach of children.Volume of Distribution
The volume of distribution of nitazoxanide has not been determined in humans.Half Life
The elimination half-life of nitazoxanide is 8-14 hours.Clearance
The clearance of nitazoxanide is 4.6 ± 2.5mL/min/kg.Here you find in details version of NIZ
Some Frequently Asked Questions About NIZ
What is NIZ?
NIZ is an antiparasitic medication used to treat infections caused by parasites, such as Giardia, Cryptosporidium, and Entamoeba species.
What is NIZ used to treat?
NIZ is used to treat infections caused by parasites, such as Giardia, Cryptosporidium, and Entamoeba species. It can also be used to treat diarrhea caused by these parasites.
How does NIZ work?
NIZ works by blocking the energy production process of parasites, which inhibits their growth and reproduction. This ultimately leads to the death of the parasites.
Are there any side effects associated with NIZ?
The most common side effects of NIZ are nausea, diarrhea, stomach pain, and vomiting. If these side effects are severe or do not go away, talk to your doctor about other treatment options.
Does NIZ interact with any other drugs?
NIZ may interact with certain antibiotics, medications for diabetes, warfarin, and other medications. It is important to tell your doctor about all prescription, over-the-counter, and herbal medications that you are taking before using NIZ.
Who should not take NIZ?
You should not take NIZ if you are pregnant, breastfeeding, have severe liver or kidney disease, or are allergic to NIZ or any of its ingredients. Talk to your doctor before starting any new medications.
What should I do if I miss a dose of NIZ?
If you miss a dose of NIZ, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Do not double your dose to make up for the missed dose.
How long does it take for NIZ to work?
The time it takes for NIZ to work varies depending on the type of infection and the dosage. Most infections improve after 1 to 3 days of treatment, but it may take up to 10 days for some infections.
What should I do if I experience an allergic reaction to NIZ?
If you experience an allergic reaction to NIZ, such as hives, difficulty breathing, or swelling, stop taking the medication and seek emergency medical attention.
Is NIZ safe for children?
Yes, NIZ is safe for children. It is important to follow the dosage instructions as directed by your doctor. Do not give your child a double dose if they miss one.
Will I need to take a second dose of NIZ if my infection does not improve?
In most cases, a single dose of NIZ is enough to treat an infection. However, if your infection does not improve after one dose, your doctor may prescribe a second dose of the medication.
Is NIZ approved by the FDA?
Yes, NIZ is approved by the US Food and Drug Administration (FDA). It is available in the US as a prescription medication.
Can I take NIZ while breastfeeding?
No, you should not take NIZ while breastfeeding. It is unknown if the medication passes into breast milk, so it is best to avoid taking it while breastfeeding.
Can NIZ be used to treat other conditions?
No, NIZ is only approved to treat infections caused by parasites. It should not be used to treat any other condition.
Can NIZ be used to treat traveler's diarrhea?
Yes, NIZ can used to treat traveler's diarrhea caused by parasites. Talk to your doctor about the best way to treat your condition.
Is NIZ safe to take during pregnancy?
No, NIZ should not be taken during pregnancy. The safety of this medication during pregnancy has not been established. Talk to your doctor about other treatment options.
How should NIZ be stored?
NIZ should be stored at room temperature away from light and moisture. Keep the medication in the original container and do not store it in the bathroom or other damp areas.
How long should NIZ be taken?
The length of time NIZ is taken depends on the type and severity of infection. Your doctor will determine the right course of treatment for you.
Are there any other medications I can take if NIZ doesn't work?
If NIZ does not work, there are other antiparasitic medications, such as metronidazole, that can be used to treat parasitic infections. Talk to your doctor about the best treatment option for you.
What is the most common dosage of NIZ?
The most common dosage of NIZ is 500mg taken twice daily for 3 days. However, the exact dosage and length of treatment may differ depending on the type and severity of the infection.
Can NIZ be taken with food?
Yes, NIZ can be taken with or without food. If the medication causes an upset stomach, try taking it with meals or snacks.
Is NIZ available over-the-counter?
No, NIZ is not available over-the-counter. It is only available as a prescription medication.
Can NIZ be used to treat viral infections?
No, NIZ is not effective against viral infections and should not be used to treat them.
Are there any other uses for NIZ?
No, NIZ is only approved to treat parasitic infections. It should not be used to treat any other conditions.
What should I do if I experience severe stomach pain while taking NIZ?
If you experience severe stomach pain while taking NIZ, stop taking the medication and call your doctor right away. Severe stomach pain could be a sign of a serious reaction to the medication.
Is NIZ covered by insurance?
This depends on your insurance provider. Check with your insurance company to see if NIZ is covered under your plan.
Is it safe to take NIZ for a long time?
No, NIZ is not meant to be taken for a long period of time and should only be taken for the duration of your infection. Talk to your doctor about any concerns you have about long-term use of NIZ.
Does NIZ cause drowsiness?
No, NIZ does not typically cause drowsiness. However, it is important to talk to your doctor about any side effects you experience while taking this medication.
Can NIZ cause a rash?
Yes, NIZ can cause a rash in some people. If you experience a rash while taking this medication, stop taking NIZ and talk to your doctor right away.
What safety measures should be taken while taking NIZ?
It is important to read and follow the instructions in the medication guide before taking NIZ. It is also important to drink plenty of fluids to prevent dehydration and to tell your doctor if you have any pre-existing medical conditions.
Is NIZ safe to take while taking other medications?
Yes, NIZ is generally safe to take with other medications. However, it is always important to talk to your doctor about all medications you are taking before starting NIZ.
Can NIZ be taken with alcohol?
No, NIZ should not be taken with alcohol. Drinking alcohol can decrease the effectiveness of the medication and may increase the risk of serious side effects.
Can I donate blood after taking NIZ?
Yes, you can donate blood after taking NIZ. However, make sure to inform the person collecting the blood of the medications that you are taking.
What are the possible drug interactions with NIZ?
NIZ can interact with certain antibiotics, medications for diabetes, warfarin, and other medications. It is important to tell your doctor or pharmacist about all other medications you are taking before starting NIZ.
Does NIZ have any long-term side effects?
There are no known long-term side effects associated with NIZ. However, if you experience any persistent or unusual side effects, talk to your doctor right away.
Will I still need to take NIZ if I have a fever?
If you have a fever and are taking NIZ for an infection caused by parasites, it is important to finish the full course of the medication as prescribed by your doctor. Fever is a sign that your body is fighting the infection and the medication can help speed up the process.
Is NIZ available as a generic medication?
No, NIZ is not currently available as a generic medication. However, generic versions of the drug may become available in the future.
Can I take NIZ with ibuprofen?
Yes, you can take NIZ with ibuprofen. However, it is important to talk to your doctor or pharmacist before taking any other medications while taking NIZ.
Should I take NIZ if I am experiencing nausea?
If you are experiencing nausea and you are taking NIZ for a parasite infection, it is important to finish the full course of the medication as prescribed by your doctor. Taking the medication with food may help reduce nausea.
Can NIZ cause an increased heart rate?
Yes, NIZ can cause an increased heart rate. If you experience an unusually fast or erratic heartbeat while taking this medication, talk to your doctor right away.
What should I do if I experience vomiting or constipation while taking NIZ?
If you experience vomiting or constipation while taking NIZ, talk to your doctor right away. These side effects may require changes to your diet or the use of other medications.
Can I take NIZ if I have high blood pressure?
Yes, you can take NIZ if you have high blood pressure. However, it is important to monitor your blood pressure closely while taking this medication.