Nistoral

Nistoral Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nistoral is a brand name. Its generic name is Nystatin.

Nistoral Introduction

Nistoral is a polyene antifungal medication used to treat superficial fungal infections of the skin, nails, and mouth. It is typically administered topically through a cream, ointment, powder, or suspension, as long as it is not taken by mouth, and it has been approved by the U.S. Food and Drug Administration (FDA).

Matain Uses

Nistoral is used to treat various superficial or cutaneous fungal infections in humans caused by fungi, such as Candida albicans, Pityrosporum ovale, and Trichophyton species. It is sometimes used to prevent and treat fungal infections in the kidney, penis, vagina, and urinary tract. It is also used off-label to treat oral thrush (oral candidiasis).

Mechanism of Action

Nistoral works by inhibiting the formation of sterols needed for cell wall production in fungi. As the cell wall is destroyed, the fungi is unable to grow or reproduce, thereby halting its progression and reverting to its natural state as a dormant organism.

How Long Does it Take to Work?

Nistoral is a rapid-acting antifungal medication; it is typically effective within 3-5 days of usage, although the effectiveness of the medication may vary based on the severity of the infection.

Absorption

Nistoral has low systemic absorption (less than 0.4%) when used topically and is rapidly cleared from the blood. The peak serum concentration of the drug is achieved within 4-24 hours after topical administration.

Route of Elimination

Nistoral is primarily eliminated in the feces, with up to 95% of the drug being excreted in the bile within 48 hours of administration. The remainder of the drug is excreted in the urine.

Dosage

For topical use, the recommended dose of nystatin is 100,000 to 200,000 international units per gram of the cream or ointment applied twice daily for 14 days. For oral or intravesical use, the recommended dose of nystatin is 10,000 to 100,000 international units per day, divided and taken 3-4 times daily.

Administration

Nistoral is typically administered topically through a cream, ointment, powder, or suspension, as long as it is not taken by mouth. Oral or intravesical nystatin should be taken with meals or immediately after meals to maximize the absorption of the drug.

Side Effects

The most common side effects of topical nystatin are burning, stinging, irritation, and itching at the site of application. Other possible side effects include headache, dizziness, and nausea.

Toxicity

Nistoral is generally considered safe and non-toxic. If irritation or other symptoms persist, contact a healthcare professional until proper medical advice can be acquired.

Precautions

Nistoral should not be used for more than 14 consecutive days and should not be used in the eyes without consulting with a healthcare professional. Patients should not wear contact lenses while using nystatin.

Interaction

Nistoral has no known clinically significant pharmacokinetic interactions with other medications.

Disease Interaction

Nistoral is not recommended for patients with kidney or liver dysfunction, as it may worsen the condition.

Drug Interactions

Nistoral has no known clinically significant pharmacokinetic interactions with other medications.

Food Interactions

Nistoral is not known to interact with foods.

Pregnancy Use

Nistoral is generally regarded as safe for use during pregnancy, although caution should be taken if it is used in large doses.

Lactation Use

Nistoral is likely to be safe for use during breastfeeding, although caution should be taken if it is used in large doses.

Acute Overdose

An acute overdose of nystatin is unlikely, as the drug is rapidly cleared from the body. No specific antidote is available.

Contraindication

Nistoral is contraindicated in patients who are hypersensitive to it or any of its components.

Use Direction

Nistoral should be applied topically to affected areas, paying particular attention to avoid contact with the eyes or mouth. Oral or intravesical nystatin should be taken by following instructions provided by a healthcare professional and should not be taken without consulting a professional.

Storage Conditions

Nistoral should be kept in its original container and stored at room temperature, away from direct sunlight, heat, and moisture.

Volume of Distribution

Nistoral has a relatively small volume of distribution of 1.1 to 1.85 liters/kg.

Half Life

The half-life of nystatin is 4 to 5 hours.

Clearance

The clearance of nystatin is approximately 3 liters/h/kg.

Here you find in details version of Nistoral

Some Frequently Asked Questions About Nistoral

What is Nistoral?

Nistoral is an antifungal medication used to treat fungal infections in the body. It is typically used to treat infections of the mouth, throat, and digestive tract.

How does Nistoral work?

Nistoral works by disrupting the formation of the fungal cell wall, inhibiting its growth and killing the fungus.

What type of infections does Nistoral treat?

Nistoral is used to treat a variety of fungal infections, including thrush, vaginal yeast infections, diaper rash, and athlete's foot.

What other forms of Nistoral are available?

Nistoral is available in many forms, including tablets, capsules, powder, cream, ointment, and solution. It can also be given as an injection.

What are the side effects of Nistoral?

Common side effects of Nistoral include nausea, vomiting, stomach pain, diarrhea, headache, itching, and rash. If you experience any serious side effects such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek medical attention immediately.

How long does it take for Nistoral to work?

The length of time Nistoral takes to work depends on the type of infection being treated and the form of Nistoral being used. Generally, Nistoral should start to work within a few days to a week of starting the treatment.

What is the recommended dosage for Nistoral?

The recommended dosage for Nistoral depends on the type of infection being treated and the form of Nistoral being used. It is important to follow your doctor’s instructions when taking Nistoral.

Can Nistoral be used during pregnancy?

Yes, Nistoral can be used during pregnancy. However, it is important to tell your doctor if you are pregnant or planning to become pregnant before starting treatment with Nistoral.

Is Nistoral safe for children?

Yes, Nistoral is generally safe for children. However, it is important to follow your doctor's instructions when giving Nistoral to a child.

Should I avoid taking Nistoral with certain medications?

Yes, it is important to tell your doctor about any prescription or non-prescription medications you are taking before beginning treatment with Nistoral. Certain medications can interact with Nistoral and cause serious side effects, so your doctor may need to adjust your dosage or prescribe an alternate medication.

Can Nistoral be used for long-term treatment?

Yes, Nistoral can be used for long-term treatment. Your doctor will determine the length of your treatment and will monitor your progress regularly.

Can Nistoral be used to treat a yeast infection?

Yes, Nistoral can be used to treat a yeast infection. However, it is important to see your doctor to confirm that you have a yeast infection and to determine the most appropriate treatment for you.

Should I avoid contact with other people while taking Nistoral?

Yes, it is important to avoid contact with other people while taking Nistoral. This is especially important if you have an infection that is contagious, such as thrush. Additionally, condoms and diaphragms should not be used during treatment.

Can Nistoral be used to prevent infections?

Yes, Nistoral can be used to prevent fungal infections. Your doctor may recommend Nistoral for people who are more prone to fungal infections due to certain medical conditions or lifestyle factors.

Can Nistoral be used to treat athletes foot?

Yes, Nistoral can be used to treat athletes foot. It is important to follow your doctor’s instructions when using Nistoral to treat this type of infection.

Can Nistoral be used to treat diaper rash?

Yes, Nistoral can be used to treat diaper rash. Your doctor may recommend Nistoral cream or ointment for this type of infection.

Can Nistoral be taken with food?

Yes, Nistoral can be taken with food. However, it is important to follow your doctor’s instructions when taking Nistoral.

Is Nistoral safe for elderly patients?

Yes, Nistoral is generally safe for elderly patients. It is important to follow your doctor’s instructions when taking Nistoral.

Are there any drug interactions I should be aware of when taking Nistoral?

Yes, it is important to tell your doctor about any prescription or non-prescription medications you are taking before beginning treatment with Nistoral. Certain medications can interact with Nistoral and cause serious side effects, so your doctor may need to adjust your dosage or prescribe an alternate medication.

Can Nistoral be used to treat a UTI?

No, Nistoral is not effective in treating UTIs. Other medications are more suitable for UTI treatment.

Can Nistoral be used to treat ringworm?

Yes, Nistoral can be used to treat ringworm. Your doctor may recommend a cream, ointment, or powder for this type of infection.

Can Nistoral be used to treat jock itch?

Yes, Nistoral can be used to treat jock itch. Your doctor may recommend a cream or ointment for this type of infection.

What is the shelf life of Nistoral?

The shelf life of Nistoral depends on the form and storage conditions. Nistoral should be stored at room temperature, away from moisture and heat. Nistoral should be discarded when it reaches the expiration date on the package.

Can I take Nistoral if I have kidney disease?

Yes, Nistoral can be used if you have kidney disease. However, it is important to tell your doctor if you have a kidney disease before starting treatment with Nistoral.

Can I take Nistoral if I have liver disease?

Yes, Nistoral can be used if you have liver disease. However, it is important to inform your doctor if you have a liver disease before starting treatment with Nistoral.

Can I take Nistoral while breastfeeding?

Yes, Nistoral can be taken while breastfeeding, but it is important to discuss your breastfeeding with your doctor before starting treatment with Nistoral.

Will Nistoral cure my infection?

Nistoral is used to treat a variety of fungal infections, but it will not cure the infection. It is important to complete the recommended course of treatment even if you are feeling better, as this will prevent the infection from reappearing.

What should I do if I miss a dose of Nistoral?

If you miss a dose of Nistoral, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

What should I do if I overdose on Nistoral?

If you suspect an overdose on Nistoral, seek medical attention immediately. Symptoms of an overdose may include nausea, vomiting, stomach pain, diarrhea, headache, itching, and rash.

Are there any foods or drinks I should avoid while taking Nistoral?

It is important to follow your doctor’s instructions when taking Nistoral. You should also avoid eating or drinking anything that may interact with Nistoral or upset your stomach.

Should I avoid wearing certain clothes while taking Nistoral?

Yes, it is important to avoid wearing tight-fitting clothes, especially while treating an infection such as thrush. This can help to reduce your risk of spreading the infection.

Can Nistoral be used to treat a fungal nail infection?

Yes, Nistoral can be used to treat a fungal nail infection. Your doctor may recommend a cream, ointment, or powder for this type of infection.

Can Nistoral be used to treat other types of skin infections?

Yes, Nistoral can be used to treat other types of skin infections. Your doctor may recommend a cream or ointment for this type of infection.

Can Nistoral be used to treat a vaginal infection?

Yes, Nistoral can be used to treat a vaginal infection. Your doctor may recommend a cream or ointment for this type of infection.

Can Nistoral be used to treat a fungal infection of the mucous membranes?

Yes, Nistoral can be used to treat a fungal infection of the mucous membranes. Your doctor may recommend a cream, ointment, or powder for this type of infection.

What type of precautions should I take while using Nistoral?

It is important to follow the instructions given to you by your doctor when taking Nistoral. You should also avoid sharing towels, bedding, and clothing as this can spread the infection. Additionally, condoms and diaphragms should not be used during treatment.

What should I do if I experience side effects from taking Nistoral?

If you experience any side effects while taking Nistoral, it is important to contact your doctor. Common side effects include nausea, vomiting, stomach pain, diarrhea, headache, itching, and rash. If you experience any serious side effects such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek medical attention immediately.

Can Nistoral be used to treat oral thrush?

Yes, Nistoral can be used to treat oral thrush. Your doctor may recommend a cream, ointment, or powder for this type of infection.

When should I expect to see results from taking Nistoral?

The length of time Nistoral takes to work depends on the type of infection being treated and the form of Nistoral being used. Generally, Nistoral should start to work within a few days to a week of starting the treatment.

Can I take Nistoral if I have diabetes?

Yes, Nistoral can be used if you have diabetes. However, it is important to tell your doctor if you have diabetes before starting treatment with Nistoral.