Nipra

Nipra Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nipra is a brand name. Its generic name is Nimesulide.

Nipra

Nipra is a nonsteroidal anti-inflammatory drug (NSAID) indicated for pain relief, fever and inflammation associated with several inflammatory diseases. It was first introduced in clinical use in early 1990s. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups.

Uses For

Nipra is generally used for the relief of acute and chronic pain relief associated with various infections such as dental pain, dysmenorrhea (painful menstrual cramps),musculoskeletal conditions like arthritis, tendinitis, bursitis and acute gouty arthritis. It is also used for symptomatic relief of fever like spongy fever and recurrent fever.

Mechanism of Action

Nipra works by inhibiting the inflammatory enzyme, cyclooxygenase (COX). This enzyme is responsible for the production of prostaglandins which are necessary for the inflammatory process. By inhibiting this enzyme, COX-2 mediates the anti-inflammatory effects of Nipra.

How Long Does It Take to Work?

Nipra typically takes about 30 minutes to an hour to become effective. The onset of action varies among individuals depending on the type and intensity of the pain.

Absorption

Nipra is quickly and completely absorbed after oral administration. It reaches the peak serum level within 1-2 hours. The plasma half-life of Nipra is approximately 1 hour.

Route of Elimination

Nipra is mainly eliminated through the faecal route, with only a small fraction being eliminated through the urine.

Dosage

The recommended dose of Nipra is 10-25mg twice a day, with an increase of up to 50mg per dose after 3-5 days if required. The maximum daily dose should not exceed 100mg. It should be taken with food to reduce gastric irritation.

Administration

Nipra can be taken orally or rectally, depending on the form. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups for oral administration. It can also be administered intramuscularly, subcutaneously or intravenously.

Side Effect

Common side effects associated with Nipra use include nausea, vomiting, abdominal pain, headache, dizziness, rash, itching, dry mouth and increased risk of gastrointestinal bleeding and ulceration. Other rare but serious side effects include, insomnia, depression, anxiety, blurred vision, confusion, hallucination, anaphylaxis and liver injury.

Toxicity

The most severe toxic effect due to Nipra overdose is liver injury with prolonged use of high doses. Other toxicities that may occur due to overdose include gastrointestinal bleeding, convulsions, hypotension, shock, nephrotoxicity and respiratory depression.

Precaution

Nipra should be taken with caution in patients with pre-existing gastrointestinal bleeding, liver and kidney ailments. It should be used with caution in elderly and in children, as it has a higher risk of gastrointestinal bleeding in these patients. It should not be used in pregnant and breastfeeding women as it can affect the foetus or baby.

Interaction

Nipra can interact with other drugs like antiplatelet agents, high blood pressure medications, and cyclosporine. So, it should be taken with caution when taken with other medications. Also, it should be taken with caution in patients with allergy to other non steroidal anti-inflammatory drugs,and should not be taken if you are taking aspirin.

Disease Interaction

Nipra should be used with caution in patients with bleeding disorders, heart or kidney diseases, as it can cause a further increase in the risk of serious side effects. Also, it should not be used if you have a history of asthma, as it can trigger an asthma attack.

Drug Interaction

Nipra may interact with other medications like anticoagulants, aspirin, corticosteroids, antimalarials, lithium, aspirin, phenytoin, phenobarbital and warfarin. So, if you are taking any of these drugs, you should inform your doctor.

Food Interactions

Nipra should be taken with food to reduce stomach irritation. Alcohol should be avoided while using Nipra; as it can increase the risk of stomach bleeding.

Pregnancy Use

Nipra should not be used during pregnancy as it can affect the health of the baby or the mother. The risks associated with taking Nipra are more than the benefits during pregnancy. So, it is recommended to avoid taking Nipra during pregnancy.

Lactation Use

Nipra should not be used during lactation as it can get into the breast milk, which may affect the baby. Also, the risks associated with taking Nipra are more than the benefits during lactation.

Acute Overdose

Acute overdose of Nipra may lead to symptoms like nausea, vomiting, drowsiness, abdominal pain, dizziness, sweating, and confusion. Liver and kidney toxicity can also occur due to prolonged use or overdose. In case of acute overdose, immediate medical attention should be sought.

Contraindication

Nipra should not be used in patients with hypersensitivity to this drug, those with pre-existing liver, kidney, and heart diseases, and those with gastrointestinal bleeding or ulcers. It should also not be used in pregnant and breastfeeding women, and in patients taking aspirin.

Use Directions

Nipra should be administered as per the doctor’s advice. It should not be taken in excess of the recommended dose, and should be taken with food to reduce the risk of gastrointestinal side effects. It should also be stored at room temperature and should be kept away from direct sunlight.

Storage Condition

Nipra should be stored at room temperature away from direct sunlight and moisture. It should be kept out of reach of children and pets.

Volume of Distribution

The volume of distribution of Nipra is 0.3 L per kg.

Half Life

The half life of Nipra is 1 hour.

Clearance

The clearance of Nipra is 1.2 mL per minute per kg.

Here you find in details version of Nipra

Some Frequently Asked Questions About Nipra

What is Nipra?

Nipra is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation.

Who manufactures Nipra?

Nipra is manufactured and marketed by various pharmaceutical companies.

What are the uses of Nipra?

Nipra is used to treat symptoms of arthritis, menstrual cramps, and other types of pain. It is also used to reduce fever.

What are the side effects of Nipra?

Common side effects of Nipra include nausea, vomiting, diarrhea, stomach pain, indigestion, headache, dizziness, and rash. Serious side effects may include heart attacks, strokes, and kidney damage.

Is Nipra safe to use?

Nipra should only be used under the supervision of a medical doctor. It is important to follow all the instruction provided by your doctor.

How long should I take Nipra?

The duration of treatment with Nipra must be determined by your doctor. It should not be used longer than the recommended period.

Does Nipra interact with any other drugs?

Nipra may interact with other drugs, including certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nipra.

What are the warnings associated with Nipra?

Nipra should not be used in people with conditions such as asthma, bleeding or blood clotting problems, or heart problems. It is also not recommended for people who are pregnant or breastfeeding. It should be avoided in people with liver or kidney disease.

What is the dosage of Nipra?

The dosage of Nipra will depend on the condition being treated, your age, and other factors. It is important to follow your doctor’s instructions carefully when taking this medication.

What should I do if I miss a dose of Nipra?

If you miss a dose of Nipra, take it as soon as possible. Do not take two doses at the same time. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

What should I do if I overdose on Nipra?

If you or someone else has overdosed on Nipra, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, and abdominal pain.

Can Nipra be used in children?

Nipra is not recommended for use in children under 12 years of age. If your child needs a pain reliever, speak to your doctor about alternative medications.

Is Nipra available over-the-counter?

No, Nipra is not available over-the-counter. It requires a prescription from your doctor.

Can I take Nipra with food?

Yes, it is recommended to take Nipra with food or a glass of milk. This will help reduce the risk of stomach upset.

Does Nipra cause drowsiness?

Yes, Nipra may cause drowsiness or dizziness. It is important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.

Can Nipra be taken with alcohol?

No, it is not recommended to mix Nipra with alcohol. Alcohol can increase the risk of side effects from this medication.

What should I avoid while taking Nipra?

You should avoid activities that require mental alertness, such as driving or operating machinery, until you know how Nipra affects you. It is also important to avoid taking other medications that could interact with Nipra, unless instructed by your doctor.

Can Nipra cause weight gain?

There is no evidence that Nipra causes weight gain. However, it is possible to gain weight while taking Nipra if you are not careful with your diet.

What should I do if I experience an allergic reaction to Nipra?

If you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking the medication and contact your doctor immediately.

What should I tell my doctor before taking Nipra?

Before starting treatment with Nipra, it is important to tell your doctor about any other medications you are taking, your medical history, and any allergies you may have.

What form of Nipra is available?

Nipra is available in tablet, capsule, and oral suspension form.

What is the generic name of Nipra?

The generic name of Nipra is Nipra.

Does Nipra cause constipation?

Yes, Nipra may cause constipation. If you experience constipation while taking Nipra, speak to your doctor about other medications that may reduce this side effect.

Should Nipra be taken with food?

It is recommended to take Nipra with food or a glass of milk to reduce the risk of stomach upset.

What if I forget to take my dose of Nipra?

If you forget to take a dose of Nipra, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

Is it safe to take Nipra while pregnant?

No, it is not recommended for pregnant women to take Nipra. Speak to your doctor about alternative medications.

Does Nipra cause dehydration?

Dehydration may be a side effect of Nipra use. It is important to drink plenty of fluids while taking this medication.

Can Nipra lower blood pressure?

Yes, Nipra may lower blood pressure. If you are taking medications to lower your blood pressure, speak to your doctor before taking Nipra.

Can I take Nipra with other NSAIDs?

No, it is not recommended to take Nipra with other NSAIDs. Taking multiple NSAIDs could increase your risk of side effects.

Should I take Nipra with food or on an empty stomach?

It is recommended to take Nipra with food or a glass of milk to reduce the risk of stomach upset.

Can Nipra be crushed or split?

You may be able to crush or split Nipra tablets. However, it is important to check with your doctor before doing so.

What are the possible drug interactions with Nipra?

Nipra may interact with certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nipra.

Is it safe to use Nipra long-term?

No, it is not recommended to use Nipra long-term. Long-term use of Nipra may increase the risk of side effects.

Can Nipra be used to treat stomach ulcers?

No, Nipra is not recommended for treating stomach ulcers. Speak to your doctor about other medications that may be more effective.

Can I take ibuprofen and Nipra together?

No, it is not recommended to take ibuprofen and Nipra together. Taking multiple NSAIDs could increase your risk of side effects.

Can I take Nipra while breastfeeding?

No, it is not recommended for breastfeeding women to take Nipra. Speak to your doctor about alternative medications.

Does Nipra cause kidney damage?

Yes, long-term use of Nipra may increase the risk of kidney damage. It is important to use this medication only under the guidance of your doctor.

Can Nipra be used to treat fever?

Yes, Nipra is used to treat fever by reducing inflammation and reducing body temperature.

Can Nipra cause skin rash?

Yes, Nipra may cause a skin rash. If you experience any skin rash while taking Nipra, contact your doctor immediately.

Can Nipra be taken with antibiotics?

Yes, Nipra can be taken with certain antibiotics. However, it is important to tell your doctor about any medications you are taking before taking Nipra.

Does Nipra elevate liver enzymes?

Yes, long-term use of Nipra may cause elevated liver enzymes. It is important to speak to your doctor if you experience any signs of liver problems while taking this medication.

Can I buy Nipra online?

No, Nipra is not available to buy online. It requires a prescription from your doctor.