Nindev
Nindev Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nindev is a brand name. Its generic name is Nintedanib.
Introduction
Nindev is an oral tyrosine kinase inhibitor, which is used to treat idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). It is thought to work by inhibiting the tyrosine kinase activity of certain proteins involved in the development and progression of these diseases.
Uses
Nindev is used to treat idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Mechanism of Action
Nindev is thought to work by inhibiting the tyrosine kinase activity of certain proteins involved in the development and progression of IPF and SSc-ILD. By blocking these proteins, nintedanib is thought to help slow the progression of these lung diseases.
How Long Does It Take to Work?
The length of time it takes for nintedanib to work varies from patient to patient, but some improvements may be seen within the first few weeks of treatment. It typically takes around three months for patients to start to experience their maximum benefit from the drug.
Absorption
Nindev is rapidly absorbed after oral administration, with peak concentrations observed within 1-2 hours.
Route of Elimination
Nindev is metabolized in the liver via multiple pathways and is excreted in the urine and feces.
Dosage
The recommended dosage of nintedanib for the treatment of idiopathic pulmonary fibrosis (IPF) is 150 mg taken by mouth twice daily with food. The recommended dosage for the treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is 300 mg by mouth twice daily with food. It is important to take nintedanib exactly as prescribed by your doctor.
Administration
Nindev should always be taken with food. It is important to take nintedanib exactly as prescribed by your doctor.
Side Effect
The most common side effects of nintedanib include diarrhea, abdominal pain, headache, nausea, vomiting, rash, fatigue, decreased appetite, and alveolitis. Other potential side effects include flatulence, elevated liver enzymes, and increased blood pressure.
Toxicity
Nindev has a low toxicity profile and is generally well-tolerated. However, overdosage of nintedanib may potentially cause serious side effects, including nausea, vomiting, and abdominal pain.
Precaution
Nindev should be used with caution in patients with impaired hepatic function or moderate to severe renal function. Nindev should not be used in pregnant women or nursing mothers. Patients should talk to their doctor before taking nintedanib if they have any pre-existing medical conditions, such as liver or kidney disease, or if they are taking any other medications, especially drugs that affect the liver or kidneys.
Interaction
Nindev may interact with other drugs, including drugs that affect the liver or kidneys, and drugs that increase the risk of bleeding. Patients should talk to their doctor before taking nintedanib if they are taking any other medications.
Disease Interaction
Nindev may be used to treat idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). Nindev should not be used to treat any other diseases.
Drug Interaction
Nindev may interact with other drugs, including anticoagulants (e.g. warfarin), anticonvulsants (e.g. carbamazepine), drugs that affect kidney or liver function (e.g. leflunomide), and drugs that increase the risk of bleeding (e.g. aspirin). Patients should tell their doctor about all medications they are taking before starting nintedanib.
Food Interaction
Nindev should be taken with food. Patients should not take nintedanib with grapefruit juice, as this may increase the amount of nintedanib in their system.
Pregnancy Use
Nindev should not be used during pregnancy, as it can cause harm to an unborn baby. Any woman who is pregnant or planning to become pregnant should talk to her doctor before taking nintedanib.
Lactation Use
Nindev has not been studied in nursing mothers, so it is not known if it is safe to take while breastfeeding. Women should talk to their doctor before taking nintedanib while breastfeeding.
Acute Overdose
An acute overdose of nintedanib may cause nausea, vomiting, and abdominal pain. Patients should seek immediate medical attention if they experience any of these symptoms.
Contraindication
Nindev should not be used in patients with moderate to severe hepatic impairment, or in combination with bosentan, as this may increase the risk of severe side effects.
Use Direction
Nindev should be taken exactly as prescribed by your doctor. It should always be taken with food. If you miss a dose, take it as soon as you remember. Do not double up on your dose.
Storage Condition
Nindev should be stored at room temperature and away from direct sunlight. It should also be kept in a dry place and out of the reach of children and pets.
Volume of Distribution
The volume of distribution (Vd) of nintedanib is 17 liters.
Half Life
The half-life (t1/2) of nintedanib is approximately 10 hours.
Clearance
The clearance (Cl) of nintedanib is approximately 41 liters/hour.
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