Nimexin P

Nimexin P Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nimexin P is a brand name. Its generic name is Nimesulide.

Nimexin P

Nimexin P is a nonsteroidal anti-inflammatory drug (NSAID) indicated for pain relief, fever and inflammation associated with several inflammatory diseases. It was first introduced in clinical use in early 1990s. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups.

Uses For

Nimexin P is generally used for the relief of acute and chronic pain relief associated with various infections such as dental pain, dysmenorrhea (painful menstrual cramps),musculoskeletal conditions like arthritis, tendinitis, bursitis and acute gouty arthritis. It is also used for symptomatic relief of fever like spongy fever and recurrent fever.

Mechanism of Action

Nimexin P works by inhibiting the inflammatory enzyme, cyclooxygenase (COX). This enzyme is responsible for the production of prostaglandins which are necessary for the inflammatory process. By inhibiting this enzyme, COX-2 mediates the anti-inflammatory effects of Nimexin P.

How Long Does It Take to Work?

Nimexin P typically takes about 30 minutes to an hour to become effective. The onset of action varies among individuals depending on the type and intensity of the pain.

Absorption

Nimexin P is quickly and completely absorbed after oral administration. It reaches the peak serum level within 1-2 hours. The plasma half-life of Nimexin P is approximately 1 hour.

Route of Elimination

Nimexin P is mainly eliminated through the faecal route, with only a small fraction being eliminated through the urine.

Dosage

The recommended dose of Nimexin P is 10-25mg twice a day, with an increase of up to 50mg per dose after 3-5 days if required. The maximum daily dose should not exceed 100mg. It should be taken with food to reduce gastric irritation.

Administration

Nimexin P can be taken orally or rectally, depending on the form. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups for oral administration. It can also be administered intramuscularly, subcutaneously or intravenously.

Side Effect

Common side effects associated with Nimexin P use include nausea, vomiting, abdominal pain, headache, dizziness, rash, itching, dry mouth and increased risk of gastrointestinal bleeding and ulceration. Other rare but serious side effects include, insomnia, depression, anxiety, blurred vision, confusion, hallucination, anaphylaxis and liver injury.

Toxicity

The most severe toxic effect due to Nimexin P overdose is liver injury with prolonged use of high doses. Other toxicities that may occur due to overdose include gastrointestinal bleeding, convulsions, hypotension, shock, nephrotoxicity and respiratory depression.

Precaution

Nimexin P should be taken with caution in patients with pre-existing gastrointestinal bleeding, liver and kidney ailments. It should be used with caution in elderly and in children, as it has a higher risk of gastrointestinal bleeding in these patients. It should not be used in pregnant and breastfeeding women as it can affect the foetus or baby.

Interaction

Nimexin P can interact with other drugs like antiplatelet agents, high blood pressure medications, and cyclosporine. So, it should be taken with caution when taken with other medications. Also, it should be taken with caution in patients with allergy to other non steroidal anti-inflammatory drugs,and should not be taken if you are taking aspirin.

Disease Interaction

Nimexin P should be used with caution in patients with bleeding disorders, heart or kidney diseases, as it can cause a further increase in the risk of serious side effects. Also, it should not be used if you have a history of asthma, as it can trigger an asthma attack.

Drug Interaction

Nimexin P may interact with other medications like anticoagulants, aspirin, corticosteroids, antimalarials, lithium, aspirin, phenytoin, phenobarbital and warfarin. So, if you are taking any of these drugs, you should inform your doctor.

Food Interactions

Nimexin P should be taken with food to reduce stomach irritation. Alcohol should be avoided while using Nimexin P; as it can increase the risk of stomach bleeding.

Pregnancy Use

Nimexin P should not be used during pregnancy as it can affect the health of the baby or the mother. The risks associated with taking Nimexin P are more than the benefits during pregnancy. So, it is recommended to avoid taking Nimexin P during pregnancy.

Lactation Use

Nimexin P should not be used during lactation as it can get into the breast milk, which may affect the baby. Also, the risks associated with taking Nimexin P are more than the benefits during lactation.

Acute Overdose

Acute overdose of Nimexin P may lead to symptoms like nausea, vomiting, drowsiness, abdominal pain, dizziness, sweating, and confusion. Liver and kidney toxicity can also occur due to prolonged use or overdose. In case of acute overdose, immediate medical attention should be sought.

Contraindication

Nimexin P should not be used in patients with hypersensitivity to this drug, those with pre-existing liver, kidney, and heart diseases, and those with gastrointestinal bleeding or ulcers. It should also not be used in pregnant and breastfeeding women, and in patients taking aspirin.

Use Directions

Nimexin P should be administered as per the doctor’s advice. It should not be taken in excess of the recommended dose, and should be taken with food to reduce the risk of gastrointestinal side effects. It should also be stored at room temperature and should be kept away from direct sunlight.

Storage Condition

Nimexin P should be stored at room temperature away from direct sunlight and moisture. It should be kept out of reach of children and pets.

Volume of Distribution

The volume of distribution of Nimexin P is 0.3 L per kg.

Half Life

The half life of Nimexin P is 1 hour.

Clearance

The clearance of Nimexin P is 1.2 mL per minute per kg.

Here you find in details version of Nimexin P

Some Frequently Asked Questions About Nimexin P

What is Nimexin P?

Nimexin P is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation.

Who manufactures Nimexin P?

Nimexin P is manufactured and marketed by various pharmaceutical companies.

What are the uses of Nimexin P?

Nimexin P is used to treat symptoms of arthritis, menstrual cramps, and other types of pain. It is also used to reduce fever.

What are the side effects of Nimexin P?

Common side effects of Nimexin P include nausea, vomiting, diarrhea, stomach pain, indigestion, headache, dizziness, and rash. Serious side effects may include heart attacks, strokes, and kidney damage.

Is Nimexin P safe to use?

Nimexin P should only be used under the supervision of a medical doctor. It is important to follow all the instruction provided by your doctor.

How long should I take Nimexin P?

The duration of treatment with Nimexin P must be determined by your doctor. It should not be used longer than the recommended period.

Does Nimexin P interact with any other drugs?

Nimexin P may interact with other drugs, including certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nimexin P.

What are the warnings associated with Nimexin P?

Nimexin P should not be used in people with conditions such as asthma, bleeding or blood clotting problems, or heart problems. It is also not recommended for people who are pregnant or breastfeeding. It should be avoided in people with liver or kidney disease.

What is the dosage of Nimexin P?

The dosage of Nimexin P will depend on the condition being treated, your age, and other factors. It is important to follow your doctor’s instructions carefully when taking this medication.

What should I do if I miss a dose of Nimexin P?

If you miss a dose of Nimexin P, take it as soon as possible. Do not take two doses at the same time. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

What should I do if I overdose on Nimexin P?

If you or someone else has overdosed on Nimexin P, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, and abdominal pain.

Can Nimexin P be used in children?

Nimexin P is not recommended for use in children under 12 years of age. If your child needs a pain reliever, speak to your doctor about alternative medications.

Is Nimexin P available over-the-counter?

No, Nimexin P is not available over-the-counter. It requires a prescription from your doctor.

Can I take Nimexin P with food?

Yes, it is recommended to take Nimexin P with food or a glass of milk. This will help reduce the risk of stomach upset.

Does Nimexin P cause drowsiness?

Yes, Nimexin P may cause drowsiness or dizziness. It is important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.

Can Nimexin P be taken with alcohol?

No, it is not recommended to mix Nimexin P with alcohol. Alcohol can increase the risk of side effects from this medication.

What should I avoid while taking Nimexin P?

You should avoid activities that require mental alertness, such as driving or operating machinery, until you know how Nimexin P affects you. It is also important to avoid taking other medications that could interact with Nimexin P, unless instructed by your doctor.

Can Nimexin P cause weight gain?

There is no evidence that Nimexin P causes weight gain. However, it is possible to gain weight while taking Nimexin P if you are not careful with your diet.

What should I do if I experience an allergic reaction to Nimexin P?

If you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking the medication and contact your doctor immediately.

What should I tell my doctor before taking Nimexin P?

Before starting treatment with Nimexin P, it is important to tell your doctor about any other medications you are taking, your medical history, and any allergies you may have.

What form of Nimexin P is available?

Nimexin P is available in tablet, capsule, and oral suspension form.

What is the generic name of Nimexin P?

The generic name of Nimexin P is Nimexin P.

Does Nimexin P cause constipation?

Yes, Nimexin P may cause constipation. If you experience constipation while taking Nimexin P, speak to your doctor about other medications that may reduce this side effect.

Should Nimexin P be taken with food?

It is recommended to take Nimexin P with food or a glass of milk to reduce the risk of stomach upset.

What if I forget to take my dose of Nimexin P?

If you forget to take a dose of Nimexin P, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

Is it safe to take Nimexin P while pregnant?

No, it is not recommended for pregnant women to take Nimexin P. Speak to your doctor about alternative medications.

Does Nimexin P cause dehydration?

Dehydration may be a side effect of Nimexin P use. It is important to drink plenty of fluids while taking this medication.

Can Nimexin P lower blood pressure?

Yes, Nimexin P may lower blood pressure. If you are taking medications to lower your blood pressure, speak to your doctor before taking Nimexin P.

Can I take Nimexin P with other NSAIDs?

No, it is not recommended to take Nimexin P with other NSAIDs. Taking multiple NSAIDs could increase your risk of side effects.

Should I take Nimexin P with food or on an empty stomach?

It is recommended to take Nimexin P with food or a glass of milk to reduce the risk of stomach upset.

Can Nimexin P be crushed or split?

You may be able to crush or split Nimexin P tablets. However, it is important to check with your doctor before doing so.

What are the possible drug interactions with Nimexin P?

Nimexin P may interact with certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nimexin P.

Is it safe to use Nimexin P long-term?

No, it is not recommended to use Nimexin P long-term. Long-term use of Nimexin P may increase the risk of side effects.

Can Nimexin P be used to treat stomach ulcers?

No, Nimexin P is not recommended for treating stomach ulcers. Speak to your doctor about other medications that may be more effective.

Can I take ibuprofen and Nimexin P together?

No, it is not recommended to take ibuprofen and Nimexin P together. Taking multiple NSAIDs could increase your risk of side effects.

Can I take Nimexin P while breastfeeding?

No, it is not recommended for breastfeeding women to take Nimexin P. Speak to your doctor about alternative medications.

Does Nimexin P cause kidney damage?

Yes, long-term use of Nimexin P may increase the risk of kidney damage. It is important to use this medication only under the guidance of your doctor.

Can Nimexin P be used to treat fever?

Yes, Nimexin P is used to treat fever by reducing inflammation and reducing body temperature.

Can Nimexin P cause skin rash?

Yes, Nimexin P may cause a skin rash. If you experience any skin rash while taking Nimexin P, contact your doctor immediately.

Can Nimexin P be taken with antibiotics?

Yes, Nimexin P can be taken with certain antibiotics. However, it is important to tell your doctor about any medications you are taking before taking Nimexin P.

Does Nimexin P elevate liver enzymes?

Yes, long-term use of Nimexin P may cause elevated liver enzymes. It is important to speak to your doctor if you experience any signs of liver problems while taking this medication.

Can I buy Nimexin P online?

No, Nimexin P is not available to buy online. It requires a prescription from your doctor.