Nimble

Nimble Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nimble is a brand name. Its generic name is Nimesulide.

Nimble

Nimble is a nonsteroidal anti-inflammatory drug (NSAID) indicated for pain relief, fever and inflammation associated with several inflammatory diseases. It was first introduced in clinical use in early 1990s. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups.

Uses For

Nimble is generally used for the relief of acute and chronic pain relief associated with various infections such as dental pain, dysmenorrhea (painful menstrual cramps),musculoskeletal conditions like arthritis, tendinitis, bursitis and acute gouty arthritis. It is also used for symptomatic relief of fever like spongy fever and recurrent fever.

Mechanism of Action

Nimble works by inhibiting the inflammatory enzyme, cyclooxygenase (COX). This enzyme is responsible for the production of prostaglandins which are necessary for the inflammatory process. By inhibiting this enzyme, COX-2 mediates the anti-inflammatory effects of Nimble.

How Long Does It Take to Work?

Nimble typically takes about 30 minutes to an hour to become effective. The onset of action varies among individuals depending on the type and intensity of the pain.

Absorption

Nimble is quickly and completely absorbed after oral administration. It reaches the peak serum level within 1-2 hours. The plasma half-life of Nimble is approximately 1 hour.

Route of Elimination

Nimble is mainly eliminated through the faecal route, with only a small fraction being eliminated through the urine.

Dosage

The recommended dose of Nimble is 10-25mg twice a day, with an increase of up to 50mg per dose after 3-5 days if required. The maximum daily dose should not exceed 100mg. It should be taken with food to reduce gastric irritation.

Administration

Nimble can be taken orally or rectally, depending on the form. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups for oral administration. It can also be administered intramuscularly, subcutaneously or intravenously.

Side Effect

Common side effects associated with Nimble use include nausea, vomiting, abdominal pain, headache, dizziness, rash, itching, dry mouth and increased risk of gastrointestinal bleeding and ulceration. Other rare but serious side effects include, insomnia, depression, anxiety, blurred vision, confusion, hallucination, anaphylaxis and liver injury.

Toxicity

The most severe toxic effect due to Nimble overdose is liver injury with prolonged use of high doses. Other toxicities that may occur due to overdose include gastrointestinal bleeding, convulsions, hypotension, shock, nephrotoxicity and respiratory depression.

Precaution

Nimble should be taken with caution in patients with pre-existing gastrointestinal bleeding, liver and kidney ailments. It should be used with caution in elderly and in children, as it has a higher risk of gastrointestinal bleeding in these patients. It should not be used in pregnant and breastfeeding women as it can affect the foetus or baby.

Interaction

Nimble can interact with other drugs like antiplatelet agents, high blood pressure medications, and cyclosporine. So, it should be taken with caution when taken with other medications. Also, it should be taken with caution in patients with allergy to other non steroidal anti-inflammatory drugs,and should not be taken if you are taking aspirin.

Disease Interaction

Nimble should be used with caution in patients with bleeding disorders, heart or kidney diseases, as it can cause a further increase in the risk of serious side effects. Also, it should not be used if you have a history of asthma, as it can trigger an asthma attack.

Drug Interaction

Nimble may interact with other medications like anticoagulants, aspirin, corticosteroids, antimalarials, lithium, aspirin, phenytoin, phenobarbital and warfarin. So, if you are taking any of these drugs, you should inform your doctor.

Food Interactions

Nimble should be taken with food to reduce stomach irritation. Alcohol should be avoided while using Nimble; as it can increase the risk of stomach bleeding.

Pregnancy Use

Nimble should not be used during pregnancy as it can affect the health of the baby or the mother. The risks associated with taking Nimble are more than the benefits during pregnancy. So, it is recommended to avoid taking Nimble during pregnancy.

Lactation Use

Nimble should not be used during lactation as it can get into the breast milk, which may affect the baby. Also, the risks associated with taking Nimble are more than the benefits during lactation.

Acute Overdose

Acute overdose of Nimble may lead to symptoms like nausea, vomiting, drowsiness, abdominal pain, dizziness, sweating, and confusion. Liver and kidney toxicity can also occur due to prolonged use or overdose. In case of acute overdose, immediate medical attention should be sought.

Contraindication

Nimble should not be used in patients with hypersensitivity to this drug, those with pre-existing liver, kidney, and heart diseases, and those with gastrointestinal bleeding or ulcers. It should also not be used in pregnant and breastfeeding women, and in patients taking aspirin.

Use Directions

Nimble should be administered as per the doctor’s advice. It should not be taken in excess of the recommended dose, and should be taken with food to reduce the risk of gastrointestinal side effects. It should also be stored at room temperature and should be kept away from direct sunlight.

Storage Condition

Nimble should be stored at room temperature away from direct sunlight and moisture. It should be kept out of reach of children and pets.

Volume of Distribution

The volume of distribution of Nimble is 0.3 L per kg.

Half Life

The half life of Nimble is 1 hour.

Clearance

The clearance of Nimble is 1.2 mL per minute per kg.

Here you find in details version of Nimble

Some Frequently Asked Questions About Nimble

What is Nimble?

Nimble is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation.

Who manufactures Nimble?

Nimble is manufactured and marketed by various pharmaceutical companies.

What are the uses of Nimble?

Nimble is used to treat symptoms of arthritis, menstrual cramps, and other types of pain. It is also used to reduce fever.

What are the side effects of Nimble?

Common side effects of Nimble include nausea, vomiting, diarrhea, stomach pain, indigestion, headache, dizziness, and rash. Serious side effects may include heart attacks, strokes, and kidney damage.

Is Nimble safe to use?

Nimble should only be used under the supervision of a medical doctor. It is important to follow all the instruction provided by your doctor.

How long should I take Nimble?

The duration of treatment with Nimble must be determined by your doctor. It should not be used longer than the recommended period.

Does Nimble interact with any other drugs?

Nimble may interact with other drugs, including certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nimble.

What are the warnings associated with Nimble?

Nimble should not be used in people with conditions such as asthma, bleeding or blood clotting problems, or heart problems. It is also not recommended for people who are pregnant or breastfeeding. It should be avoided in people with liver or kidney disease.

What is the dosage of Nimble?

The dosage of Nimble will depend on the condition being treated, your age, and other factors. It is important to follow your doctor’s instructions carefully when taking this medication.

What should I do if I miss a dose of Nimble?

If you miss a dose of Nimble, take it as soon as possible. Do not take two doses at the same time. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

What should I do if I overdose on Nimble?

If you or someone else has overdosed on Nimble, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, and abdominal pain.

Can Nimble be used in children?

Nimble is not recommended for use in children under 12 years of age. If your child needs a pain reliever, speak to your doctor about alternative medications.

Is Nimble available over-the-counter?

No, Nimble is not available over-the-counter. It requires a prescription from your doctor.

Can I take Nimble with food?

Yes, it is recommended to take Nimble with food or a glass of milk. This will help reduce the risk of stomach upset.

Does Nimble cause drowsiness?

Yes, Nimble may cause drowsiness or dizziness. It is important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.

Can Nimble be taken with alcohol?

No, it is not recommended to mix Nimble with alcohol. Alcohol can increase the risk of side effects from this medication.

What should I avoid while taking Nimble?

You should avoid activities that require mental alertness, such as driving or operating machinery, until you know how Nimble affects you. It is also important to avoid taking other medications that could interact with Nimble, unless instructed by your doctor.

Can Nimble cause weight gain?

There is no evidence that Nimble causes weight gain. However, it is possible to gain weight while taking Nimble if you are not careful with your diet.

What should I do if I experience an allergic reaction to Nimble?

If you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking the medication and contact your doctor immediately.

What should I tell my doctor before taking Nimble?

Before starting treatment with Nimble, it is important to tell your doctor about any other medications you are taking, your medical history, and any allergies you may have.

What form of Nimble is available?

Nimble is available in tablet, capsule, and oral suspension form.

What is the generic name of Nimble?

The generic name of Nimble is Nimble.

Does Nimble cause constipation?

Yes, Nimble may cause constipation. If you experience constipation while taking Nimble, speak to your doctor about other medications that may reduce this side effect.

Should Nimble be taken with food?

It is recommended to take Nimble with food or a glass of milk to reduce the risk of stomach upset.

What if I forget to take my dose of Nimble?

If you forget to take a dose of Nimble, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

Is it safe to take Nimble while pregnant?

No, it is not recommended for pregnant women to take Nimble. Speak to your doctor about alternative medications.

Does Nimble cause dehydration?

Dehydration may be a side effect of Nimble use. It is important to drink plenty of fluids while taking this medication.

Can Nimble lower blood pressure?

Yes, Nimble may lower blood pressure. If you are taking medications to lower your blood pressure, speak to your doctor before taking Nimble.

Can I take Nimble with other NSAIDs?

No, it is not recommended to take Nimble with other NSAIDs. Taking multiple NSAIDs could increase your risk of side effects.

Should I take Nimble with food or on an empty stomach?

It is recommended to take Nimble with food or a glass of milk to reduce the risk of stomach upset.

Can Nimble be crushed or split?

You may be able to crush or split Nimble tablets. However, it is important to check with your doctor before doing so.

What are the possible drug interactions with Nimble?

Nimble may interact with certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Nimble.

Is it safe to use Nimble long-term?

No, it is not recommended to use Nimble long-term. Long-term use of Nimble may increase the risk of side effects.

Can Nimble be used to treat stomach ulcers?

No, Nimble is not recommended for treating stomach ulcers. Speak to your doctor about other medications that may be more effective.

Can I take ibuprofen and Nimble together?

No, it is not recommended to take ibuprofen and Nimble together. Taking multiple NSAIDs could increase your risk of side effects.

Can I take Nimble while breastfeeding?

No, it is not recommended for breastfeeding women to take Nimble. Speak to your doctor about alternative medications.

Does Nimble cause kidney damage?

Yes, long-term use of Nimble may increase the risk of kidney damage. It is important to use this medication only under the guidance of your doctor.

Can Nimble be used to treat fever?

Yes, Nimble is used to treat fever by reducing inflammation and reducing body temperature.

Can Nimble cause skin rash?

Yes, Nimble may cause a skin rash. If you experience any skin rash while taking Nimble, contact your doctor immediately.

Can Nimble be taken with antibiotics?

Yes, Nimble can be taken with certain antibiotics. However, it is important to tell your doctor about any medications you are taking before taking Nimble.

Does Nimble elevate liver enzymes?

Yes, long-term use of Nimble may cause elevated liver enzymes. It is important to speak to your doctor if you experience any signs of liver problems while taking this medication.

Can I buy Nimble online?

No, Nimble is not available to buy online. It requires a prescription from your doctor.