Nexigat

Nexigat Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nexigat is a brand name. Its generic name is Gatifloxacin.

Introduction

Nexigat is an antibiotic used for treating certain bacterial infections. It belongs to the class of drugs known as quinolone antibiotics and it works by killing certain types of bacteria.

Uses

Gatifoxacin is used to treat various bacterial infections, such as sinusitis, bronchitis, pneumonia, and others. It is also used to treat skin, ear, and urinary tract infections.

Mechanism of Action

Nexigat works by blocking the actions of two enzymes called DNA gyrase and topoisomerase IV. This prevents the bacteria from repairing and replicating its own DNA, which leads to death of the bacteria.

How Long Does it Take to Work?

Nexigat usually starts to work within 24-48 hours. However, the exact amount of time it takes to work depends on the individual and the type of infection being treated.

Absorption

Nexigat is well-absorbed after oral administration, with peak concentrations typically occurring within 1-4 hours.

Route of Elimination

Nexigat is mainly eliminated via the kidneys. Significant amounts of gatifloxacin are also eliminated via the bile.

Dosage

The recommended adult dosage of gatifloxacin is 200-400 mg taken once daily or 400-800 mg twice daily. For pediatric use, the dosage is 10 mg/kg/day taken as a single dose or divided into two doses.

Administration

Nexigat should be taken orally and should be taken with or without food. It should not be taken with antacids containing magnesium or aluminum, as they may decrease the absorption of gatifloxacin.

Side Effects

Common side effects of gatifloxacin include nausea, vomiting, diarrhea, dizziness, headache, and rash. Rare but serious side effects may include tendon rupture, arrhythmias, and liver problems.

Toxicity

Nexigat is generally well-tolerated when taken as directed. Overdose of gatifloxacin may cause nausea, vomiting, and/or diarrhea. In cases of severe overdose, the following symptoms may occur: confusion, delirium, seizures, altered heart rate, and coma.

Precaution

Nexigat should be used with caution in patients with kidney or liver disease, or in patients who are taking other medications that may interact with gatifloxacin.

Interaction

Nexigat may interact with certain antibiotics (e.g., erythromycin), antacids containing magnesium or aluminum, and the anticoagulant warfarin. Patients should consult their healthcare provider before taking any other medications while taking gatifloxacin.

Disease Interactions

Nexigat should not be used in patients with known or suspected myasthenia gravis, as serious adverse reactions can occur. Additionally, gatifloxacin is not recommended for use in patients with a known hypersensitivity to quinolone antibiotics.

Drug Interactions

Nexigat may interact with other medications, including antibiotics (e.g., erythromycin), antacids containing magnesium or aluminum, and the anticoagulant warfarin. Patients should consult their healthcare provider before taking any other medications while taking gatifloxacin.

Food Interactions

Nexigat may interact with certain foods, including dairy products, calcium-fortified juices, and iron-fortified foods or supplements. Patients should talk to their healthcare provider before taking gatifloxacin with these types of foods.

Pregnancy Use

Nexigat should not be used during pregnancy, as it can cause harm to the developing fetus. Women who are pregnant or plan to become pregnant should consult their healthcare provider before taking gatifloxacin.

Lactation Use

Nexigat is not recommended for use during lactation, as it can be passed to the infant through breast milk. Women who are breastfeeding or plan to breastfeed should consult their healthcare provider before taking gatifloxacin.

Acute Overdose

In cases of acute overdose, symptoms may include nausea, vomiting, confusion, delirium, seizures, altered heart rate, and coma. If an overdose is suspected, patients should seek immediate medical attention.

Contraindication

Nexigat should not be used in patients with known or suspected myasthenia gravis, as serious adverse reactions can occur. Additionally, gatifloxacin is not recommended for use in patients with a known hypersensitivity to quinolone antibiotics.

Use Directions

Nexigat should be taken orally as directed by the healthcare provider. It should be taken with or without food, at least one hour before or two hours after meals. The missed dose should be taken as soon as possible unless it is almost time for the next dose, in which case the missed dose should be skipped.

Storage Conditions

Nexigat should be stored at room temperature, away from moisture and heat. It should be kept out of reach of children and pets, and should not be shared with others.

Volume of Distribution

Nexigat has a volume of distribution of approximately 0.8 L/kg.

Half Life

Nexigat has an elimination half-life of approximately 4-5 hours.

Clearance

Nexigat has an oral clearance of approximately 0.1 L/hr/kg.

Here you find in details version of Nexigat

Some Frequently Asked Questions About Nexigat

1. What is gatifloxacin?

Nexigat is a prescription antibiotic. It helps treat bacterial infections in the body by killing the bacteria or stopping their growth.

2. What is Nexigat used to treat?

Nexigat is used to treat a variety of bacterial infections, including but not limited to sinusitis, bronchitis, pneumonia, skin and skin structure infections, urinary tract infections, and certain sexually transmitted diseases.

3. Who should not take Nexigat?

Nexigat should not be taken by anyone who is allergic to any of the ingredients in the medication. It is also not recommended for people with certain medical conditions, such as kidney or liver disease, or those who are pregnant or breastfeeding.

4. What are the side effects of Nexigat?

The most common side effects of Nexigat include nausea, vomiting, diarrhea, stomach upset, and headaches. Other rare but more serious side effects may include rash, itching, or hives; difficulty breathing or swallowing; blurred vision; nightmares; confusion; and seizures.

5. How should Nexigat be taken?

Nexigat should be taken as directed by your doctor. Take the medication exactly as it is prescribed, and always finish the full course of treatment. The medication should be taken with a full glass of water, and preferably with food to reduce the risk of stomach upset and nausea.

6. How long does Nexigat take to work?

Nexigat generally starts to work within 24-48 hours of taking the medication. However, it can take up to a few weeks for symptoms to improve. Do not stop taking the medication until your doctor tells you to, even if symptoms improve faster.

7. Is Nexigat safe for children?

Nexigat is not recommended for use in children under the age of 18. Safety and efficacy in children have not been established.

8. Is there anything I should avoid while taking Nexigat?

You should avoid drinking alcohol while taking Nexigat as it can increase the risk of side effects. You should also avoid taking any other medications, including over-the-counter meds, without first consulting your doctor or pharmacist.

9. Is Nexigat addictive?

Nexigat is not addictive but dependence on the drug is possible. Long-term use of the drug increases the risk of developing dependence.

10. Does Nexigat interact with other medications?

Nexigat can interact with certain other medications, so it is important to tell your doctor about any other medications, vitamins, or supplements you are taking. Nexigat may also interact with certain foods, so talk to your doctor about any dietary restrictions you may need to follow.

11. What is the most common serious side effect of Nexigat?

The most common serious side effect of Nexigat is tendonitis and tendon rupture. If you experience pain, swelling, or tenderness in a tendon, stop taking Nexigat and contact your doctor immediately.

12. What should I do if I miss a dose of Nexigat?

If you miss a dose of Nexigat, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose to make up for a missed one.

13. How long can I take Nexigat?

The length of treatment with Nexigat will vary for each person and depend on the type of infection being treated and the response to the medication. Follow your doctor's instructions carefully.

14. Is Nexigat safe for seniors?

Nexigat is generally safe for seniors, but it is important to talk to your doctor about your individual medical history and any other medications you are taking before starting Nexigat. It is also important to make sure your doctor is aware of any side effects you may be experiencing.

15. What should I do if I experience an allergic reaction to Nexigat?

If you experience any signs of an allergic reaction to Nexigat, stop taking the medication and seek medical attention immediately. Allergic reactions can include rash, itching, hives, difficulty breathing, and swelling of the face, lips, or throat.

16. Can I take Nexigat while pregnant?

Nexigat should not be taken while pregnant unless your doctor has specifically recommended it. Nexigat can potentially harm the unborn baby, so be sure to consult your doctor before taking the medication.

17. Is Nexigat safe to take while breastfeeding?

Nexigat can pass into breastmilk and could potentially harm a nursing baby. Therefore, it is not recommended to take Nexigat while breastfeeding. You should talk to your doctor before taking this medication if you are breastfeeding.

18. Can Nexigat make birth control less effective?

Yes, it is possible that Nexigat can reduce the effectiveness of some types of birth control. Talk to your doctor before taking Nexigat if you are using hormonal birth control.

19. Is it safe to use Nexigat for a long time?

Nexigat can be taken for long periods of time if it is being used to treat a chronic or long-term infection. However, you should talk to your doctor if you are taking the medication for a long period of time in order to reduce the risk of side effects.

20. Can I drink alcohol while taking Nexigat?

No, you should not drink alcohol while taking Nexigat. Drinking alcohol can increase the risk of certain side effects and can also worsen the condition being treated.

21. What forms of Nexigat are available?

Nexigat is available in the form of tablets and a liquid solution. The liquid solution may be more convenient for people who have difficulty swallowing pills.

22. How should Nexigat be stored?

Nexigat should be stored at room temperature, away from direct sunlight. Keep the medication in a secure place where it is not accessible to children or pets.

23. How long does Nexigat stay in your system?

Studies suggest that Nexigat can remain in the body for up to 48 hours after the last dose. However, this can vary from person to person.

24. Is there an alternative to Nexigat?

Yes, there are several alternatives to Nexigat, including other antibiotics and medications used to treat bacterial infections. Talk to your doctor about other treatment options.

25. Is Nexigat over-the-counter (OTC)?

No, Nexigat is a prescription medication. It is not available over-the-counter (OTC) and must be prescribed by a doctor.

26. What is the best way to take Nexigat?

The best way to take Nexigat is as directed by your doctor. Make sure to take the medication exactly as prescribed, and take it with a full glass of water and food (if possible) to reduce the risk of stomach upset and nausea.

27. Does Nexigat affect blood pressure?

Nexigat may cause low blood pressure, so it is important to monitor your blood pressure regularly while taking the medication. Talk to your doctor if you experience any changes in your blood pressure.

28. Can Nexigat cure infections?

Nexigat is an antibiotic used to treat bacterial infections. Taking the medication as directed by your doctor can help treat bacterial infections by killing the bacteria or stopping its growth.

29. How long should I wait before seeing results from Nexigat?

Nexigat generally starts to work within 24-48 hours of taking the medication. However, it may take up to a few weeks for symptoms to improve, so it is important to take the full course of treatment as prescribed by your doctor.

30. Does Nexigat interact with other medications?

Yes, Nexigat can interact with other medications, including over-the-counter medications. Make sure to tell your doctor about any other medications or supplements you are taking before starting Nexigat.